Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2007, Vol. 03 ›› Issue (02): 68 -f4. doi: 10.3877/cma.j.issn.1673-5250.2007.02.103

Original Article

The value of radiofrequency heat-coagulation minimally invasive treatment of cervical intraepithelial neoplasia in different degrees

Ge-ping YIN, Juan LI, Tong-yu ZHU, Ning HE, Shu-jun YANG, Ming CHEN, Yan HAN, Xiu-yun LI   

  1. Department of Gynecology and Obstetrics, Jinan Military General Hospital. Jinan, 250031, China
  • Published:2007-04-01
Objective

To investigate the curative effect and standardization of the treatment method to cervical intraepithelial neoplasia (CIN) by radiofrequency heat-coagulation minimally invasive treatment (RHMIT).

Methods

One hundred and thirteen patients with CIN in different degree (fifty two patients with CIN I, forty seven ones with CIN Ⅱ and fourteen ones with CIN Ⅲ), who were all confirmed by thinprep cytology test (TCT), electric colposcopy and cervical biopsy pathology, were treated by RHMIT method in order to maintain cervical integrity. All patients were strictly followed up from six months to 47 months, 32 months in average.

Results

All patients with CIN in different degree in this group were fully recovered within 4 〜7 weeks after the RHMIT and supplementary treatment. During this following up stage, five hundreds and eighty-six times of TCT and two hundreds fifty six times of cervical biopsy pathology under electric colposcopy were all not found cellular atypicality.

Conclusion

RHMIT is a simple, safe, fast, effective and repeatable method to CIN in different degree. The indications of RHMIT to CIN are definite diagnosis, standardizing plan according to individuality and strict following-up programme.

图1 射频热凝固治疗120 s,宫颈上皮完全凝固,深度达到筋膜层,宫颈管内鳞、柱上皮交界处也被凝固
图2 治疗后2周:脱痂期
图3 子宫颈CIN-Ⅱ级患者,表现为重度糜烂病变之阴道镜表现
图4 病理组织改变:宫颈上皮1/2以上极性排列紊乱,细胞有异型,可见分裂相
图5 射频热凝固治疗后6周时完全愈合:表观正常
图6 再次宫颈外口内侧组织活检病理学表现:宫颈鳞状上皮化生
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