Significance of telomerase expression in diagnosis of ovarian carcinoma

doi:10.3877/cma.j.issn.1673-5250.2006.06.113

Objective

To evaluate the clinical significance of the combined quantitative detection of hTR of ovarian cancer.

Methods

Telomerase activity express of 20 cases of ovarian epithelial tumors were detected by RTQ-PCR.

Results

The telomerase activity rate of 20 ovarian epithelial tumors were higher than that of benign ovarian tumor and normal tissue(P<0.001).The result of telomerase was significantly different between clinical stage I~Ⅱ(197.10±28.20)and clinical stage Ⅲ~Ⅳ(347.14 ± 60.10)(P < 0.05)of these tumors.

Conclusion

The quantitative detection of hTR could help to diagnosis and reveal the prognosis of ovarian epithelial cancer.

Key words: ovarian cancer, telomerase, CA125, RTQ-PCR

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