The change of coagulation state in neonatal swines with hypoxic-ischemic brain damage

doi:10.3877/cma.j.issn.1673-5250.2005.02.109

Objective

To investigate the changes of blood coagulation state and some prothrombin's function in newborn piglets at different time after hypoxic-ischemic brain damage (HIBD).

Methods

The study was performed on newborn swines (n = 40), in which the left carotid was ligated and the animals were treated under hypoxia (8% oxygen)for two hours. APTT, PT,TT and the activities of prothrombin II, V, IX and XI were measured at once and at 24,48,72 hours respectively after hypoxia and compared with the control group.

Results

APTT, PT and TT shortened and the activities of prothrombin II, V elevated obviously at HIBD 48h (P<0. 05). The activities of prothrombin IX and XI rose to the highest level at HIBD 48h.

Conclusion

In neonatal swings with HIBD, the blood coagulation state changed. At HIBD 48h, the piglets were at high coagulability, which may be related to the brain infarction in HIE.

Key words: coagulation, prothrombin, brain infarction, high coagulability

	1　李炜如，姚裕家，谭建三.新生猪缺氧缺血性脑损伤动物模型及脑损伤组织病理学改变.华西医大学报，1995，26(3)：330-333.
	2　王振义.血栓与止血——基础理论与临床，第2版.上海：上海科学技术出版社，1996，165-167.
	3　Ogawa S，Gerlach HE, Sposito C. Hypoxia modulates the barrier and coagulant function of cultured borine endothelium. J Clin Invest, 1990，85(4)：1090-1098.
	4　Ogawa S, Shreeniwes R, Brett J. The effect of hypoxia on capillary endothelial cell function ：modulation of barrier and coagulant function. Br J Heamatol, 1990，74(4) ：517-524.

[1]	Zhongbin Zhang, Kunpeng Fu, Kai Zhu, Yu Zhang, Hua Li. High tibial osteotomy and platelet rich plasma in treatment of knee osteoarthritis[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2023, 17(05): 633-641.
[2]	Xin Lu, Xin Wei, Zhibin Wang. Clinical efficacy of recombinant human soluble thrombomodulin in sepsis-induced disseminated intravascular coagulation: a meta-analysis[J]. Chinese Journal of Critical Care Medicine(Electronic Edition), 2023, 16(02): 123-129.
[3]	Zhongman Zhang, Yi Zhu, Wei Li, Di An, Yue Zou, Yu Xia, Tao Ding, Yutong Shi, Xufeng Chen. Risk factors of intracerebral hemorrhage in patients with extracorporeal membrane oxygenation[J]. Chinese Journal of Critical Care Medicine(Electronic Edition), 2022, 15(06): 454-459.
[4]	Qinfang Tang, Mingzhong Sun, Qinping Fu, Lihua Xiao, Dongmei Yan, Ying Wang, Hongjian Ji. A diabetic case with toxic shock syndrome caused by Paeniclostridium sordellii infection[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition), 2022, 16(05): 354-358.
[5]	Jie Ding, Hong Chen, Qingzhao Feng, Lei Su, Wenxian Guan. Clinical analysis of 34 cases of retrosternal goiter resection via cervical approach with bipolar coagulation forceps combined with ultrasonic knife[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2022, 16(06): 659-662.
[6]	Xiaojing Shi, Xiaole Su, Lihua Wang. Application of direct-acting oral anticoagulants in chronic kidney disease patients complicated with atrial fibrillation[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2023, 12(01): 26-31.
[7]	Hongyu Cui, Yiquan Yang, Lixia Guo, Aiguo Lyn, Zhihong Zhang, Xin Zhang, Yanping Yang, Ran Shen, Liying Lian, Zhigang Cao, Lifang Wang, Jianhua Hu, Sujie Fan. The effect of modified Ahmed glaucoma valve implantation on neovascular glaucoma at the angle-closure stage[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2023, 13(02): 76-81.
[8]	Ziyang Chen, Like Xie, Xiaofeng Hao, Xiaoyan Zhang. Progress in the retinal vascular obstruction associated with anti-phospholipid antibodies[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2022, 12(06): 367-371.
[9]	Shiming Li, Wei Huang, Ling Liu. Mechanism of high mobility group box protein 1 mediated sepsis-induced coagulopathy and treatment progress[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2023, 09(03): 269-273.
[10]	Haoran Ding, Yuguang Guan, Xiongfei Wang, Meng Zhao, Jing Wang, Mengyang Wang, Pengfei Teng, Guoming Luan. Stereo-EEG-guided multiple electrode stereo-conformal radiofrequency thermocoagulation for the treatment of drug-resistant insular epilepsy[J]. Chinese Journal of Brain Diseases and Rehabilitation(Electronic Edition), 2022, 12(04): 227-233.
[11]	Ping Lu, Jian Zou. Value of dynamic changes in coagulation and fibrinolytic markers in evaluating the prognosis of patients with acute pancreatitis[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(06): 427-432.
[12]	Xiankui Gao, Taiyun Zhao, Xingjun Lu, Hongling Zhang, Xiuluo Fang, Bichun Yan, Yin Wang, Yongcui Wang, Miaomiao Liu, Ruonan Ran. Efficacy of endoscopic electrocoagulation and tissue glue injection in the treatment of upper gastrointestinal ulcer with bleeding[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(06): 452-455.
[13]	Lina Ning, Jie Xiong. The therapeutic evaluation research on treating dysarthria after cerebral infarction with Xingnao Kaiqiao acupuncture and tongue acupuncture therapy[J]. Chinese Journal of Acupuncture and Moxibustion(Electronic Edition), 2023, 12(04): 146-150.
[14]	Jing Ding, Peiwen Li, Yingchun Xu. The application of Xingnao Kaiqiao acupuncture in severe neurological emergencies[J]. Chinese Journal of Acupuncture and Moxibustion(Electronic Edition), 2023, 12(04): 161-164.
[15]	Zhipeng Cheng, Tiening Zhang, Lei Gao, Shengjun Cao, Quan Li. Application of thromboelasticity in the diagnosis of coagulation dysfunction after early burns[J]. Chinese Journal of Hygiene Rescue(Electronic Edition), 2022, 08(05): 257-261.

Viewed

Full text

Abstract

Please choose a citation manager

Content to export