The change of coagulation state in neonatal swines with hypoxic-ischemic brain damage

doi:10.3877/cma.j.issn.1673-5250.2005.02.109

Objective

To investigate the changes of blood coagulation state and some prothrombin's function in newborn piglets at different time after hypoxic-ischemic brain damage (HIBD).

Methods

The study was performed on newborn swines (n = 40), in which the left carotid was ligated and the animals were treated under hypoxia (8% oxygen)for two hours. APTT, PT,TT and the activities of prothrombin II, V, IX and XI were measured at once and at 24,48,72 hours respectively after hypoxia and compared with the control group.

Results

APTT, PT and TT shortened and the activities of prothrombin II, V elevated obviously at HIBD 48h (P<0. 05). The activities of prothrombin IX and XI rose to the highest level at HIBD 48h.

Conclusion

In neonatal swings with HIBD, the blood coagulation state changed. At HIBD 48h, the piglets were at high coagulability, which may be related to the brain infarction in HIE.

Key words: coagulation, prothrombin, brain infarction, high coagulability

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	2　王振义.血栓与止血——基础理论与临床，第2版.上海：上海科学技术出版社，1996，165-167.
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