切换至 "中华医学电子期刊资源库"

中华妇幼临床医学杂志(电子版) ›› 2023, Vol. 19 ›› Issue (03) : 267 -272. doi: 10.3877/cma.j.issn.1673-5250.2023.03.004

专题论坛

母乳成分及其影响因素的研究现状
李敏, 熊菲()   
  1. 四川大学华西第二医院儿科、出生缺陷与相关妇儿疾病教育部重点实验室,成都 610041
  • 收稿日期:2022-11-22 修回日期:2023-03-20 出版日期:2023-06-01
  • 通信作者: 熊菲

Current research status of ingredients and their influencing factors of breast milk

Min Li, Fei Xiong()   

  1. Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2022-11-22 Revised:2023-03-20 Published:2023-06-01
  • Corresponding author: Fei Xiong
  • Supported by:
    Project Supported by the Health and Family Planning Commission of Sichuan Province(150103); Clinical Research Fund of West China Second University Hospital, Sichuan University(KL037)
引用本文:

李敏, 熊菲. 母乳成分及其影响因素的研究现状[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(03): 267-272.

Min Li, Fei Xiong. Current research status of ingredients and their influencing factors of breast milk[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(03): 267-272.

母乳(breast milk)是婴儿的最佳食物来源,包含丰富的蛋白质、脂肪、碳水化合物等营养物质及复杂的免疫球蛋白(Ig)与激素等生物活性物质。母乳在满足婴儿生长发育需求的同时,还可促进机体免疫、神经系统等的发育与完善。受母亲膳食习惯、健康状况、分娩孕龄等因素影响,母乳成分不尽相同。笔者拟就母乳成分及其相关影响因素与早产儿母乳喂养益处的最新研究现状进行阐述。

Breast milk is the best food source for infants. It contains rich proteins, lipids, carbohydrates and other nutrients as well as complex immunoglobulin (Ig) and hormones and other biologically active substances, which not only meet the growth and development needs of infants, but also promote development and improvement of their immune and nervous systems etc. of infants. The composition of breast milk is different due to influence of dietary habits and health status, gestational age at delivery and other factors of mothers of infants. The article intends to elaborate on the latest research progresses of composition of breast milk and its related influencing factors and benefits of breast feeding for preterm infants.

[1]
Thum C, Wall C, Day L, et al. Changes in human milk fat globule composition throughout lactation: a review[J]. Front Nutr, 2022, 9: 835856. DOI: 10.3389/fnut.2022.835-856.
[2]
Donovan SM. Human milk proteins: composition and physiological significance[J]. Nestle Nutr Inst Workshop Ser, 2019, 90: 93-101. DOI: 10.1159/000490298.
[3]
Layman DK, Lönnerdal B, Fernstrom JD. Applications for α-lactalbumin in human nutrition[J]. Nutr Rev, 2018, 76(6): 444-460. DOI: 10.1093/nutrit/nuy004.
[4]
Kim YJ. Pivotal roles of prolactin and other hormones in lactogenesis and the nutritional composition of human milk[J]. Clin Exp Pediatr, 2020, 63(8): 312-313. DOI: 10.3345/cep.2020.00311.
[5]
Liao YL, Weber D, Xu W, et al. Absolute quantification of human milk caseins and the Whey/Casein ratio during the first year of lactation[J]. J Proteome Res, 2017, 16(11): 4113-4121. DOI: 10.1021/acs.jproteome.7b00486.
[6]
李贺,腾飞. 乳脂肪球膜蛋白组成及其功能特性[J]. 中国乳品工业2022, 50(3): 37-42, 47. DOI: 10.19827/j.issn1001-2230.2022.03.007.
[7]
Samuel TM, Zhou QL, Giuffrida F, et al. Nutritional and non-nutritional composition of human milk is modulated by maternal, infant, and methodological factors[J]. Front Nutr, 2020, 7: 576133. DOI: 10.3389/fnut.2020.576133.
[8]
Miles EA, Childs CE, Calder PC. Long-chain polyunsaturated fatty acids (LCPUFAs) and the developing immune system: a narrative review[J]. Nutrients, 2021, 13(1): 247. DOI: 10.3390/nu13010247.
[9]
王宝珍,孙永静,张慧. 母乳成分调查及影响因素分析[J]. 宁夏医学杂志2016, 38(8): 758-759. DOI: 10.13621/j.1001-5949.2016.08.0758.
[10]
闫淑媛,匡晓妮,钱红艳,等. 母乳成分动态分析及与乳母膳食营养摄入、婴儿生长发育关系研究[J]. 中国妇幼健康研究2020, 31(11): 1531-1536. DOI: 10.3969/j.issn.1673-5293.2020.011.019.
[11]
Sekerel BE, Bingol G, Cullu Cokugras F, et al. An expert panel statement on the beneficial effects of human milk oligosaccharides (HMOs) in early life and potential utility of HMO-supplemented infant formula in cow′s milk protein allergy[J]. J Asthma Allergy, 2021, 14: 1147-1164. DOI: 10.2147/JAA.S323734.
[12]
Bode L. Human milk oligosaccharides: structure and Functions[J]. Nestle Nutr Inst Workshop Ser, 2020, 94: 115-123. DOI: 10.1159/000505339.
[13]
Wiciński M, Sawicka E, Gebalski J, et al. Human milk oligosaccharides: health benefits, potential applications in infant formulas, and pharmacology[J]. Nutrients, 2020, 12(1): 266. DOI: 10.3390/nu12010266.
[14]
Karcz K, Królak-Olejnik B. Vegan or vegetarian diet and breast milk composition-a systematic review[J]. Crit Rev Food Sci Nutr, 2021, 61(7): 1081-1098. DOI: 10.1080/10408398.2020.1753650.
[15]
Nguyen MTT, Kim J, Lee H, et al. A comparison of vitamin and lutein concentrations in breast milk from four Asian countries[J]. Nutrients, 2020, 12(6): 1794. DOI: 10.3390/nu12061794.
[16]
Ametaj BN, Nonnecke BJ, Franklin ST, et al. Dietary vitamin A modulates the concentrations of RRR-alpha-tocopherol in plasma lipoproteins from calves fed milk replacer[J]. J Nutr, 2000, 130(3): 629-636. DOI: 10.1093/jn/130.3.629.
[17]
Grilo EC, Medeiros WF, Silva AG, et al. Maternal supplementation with a megadose of vitamin a reduces colostrum level of α-tocopherol: a randomised controlled trial[J]. J Hum Nutr Diet, 2016, 29(5): 652-661. DOI: 10.1111/jhn.12381.
[18]
Við Streym S, Højskov CS, Møller UK, et al. Vitamin D content in human breast milk: a 9-month follow-up study[J]. Am J Clin Nutr, 2016, 103(1): 107-114. DOI: 10.3945/ajcn.115.115105.
[19]
Bae YJ, Kratzsch J. Vitamin D and calcium in the human breast milk[J]. Best Pract Res Clin Endocrinol Metab, 2018, 32(1): 39-45. DOI: 10.1016/j.beem.2018.01.007.
[20]
Wei M, Deng Z, Liu B, et al. Investigation of amino acids and minerals in Chinese breast milk[J]. J Sci Food Agric, 2020, 100(10): 3920-3931. DOI: 10.1002/jsfa.10434.
[21]
中国营养学会"中国产褥期(月子)妇女膳食"工作组. 中国产褥期(月子)妇女膳食建建议[J]. 营养学报2020, 42(1): 3-6. DOI: 10.3969/j.issn.0512-7955.2020.01.002.
[22]
Magri G, Comerma L, Pybus M, et al. Human secretory IgM emerges from plasma cells clonally related to gut memory B cells and targets highly diverse commensals[J]. Immunity, 2017, 47(1): 118.e8-134.e8. DOI: 10.1016/j.immuni.2017.06.013.
[23]
Carr LE, Virmani MD, Rosa F, et al. Role of human milk bioactives on infants′ gut and immune health[J]. Front Immunol, 2021, 12: 604080. DOI: 10.3389/fimmu.2021.604080.
[24]
陈同辛,洪莉,王华,等. 中国婴儿轻中度非IgE介导的牛奶蛋白过敏诊断和营养干预指南[J]. 中华实用儿科临床杂志2022, 37(4): 241-250. DOI: 10.3760/cma.j.cn101070-20220106-00016.
[25]
Järvinen KM, Martin H, Oyoshi MK. Immunomodulatory effects of breast milk on food allergy[J]. Ann Allergy Asthma Immunol, 2019, 123(2): 133-143. DOI: 10.1016/j.anai.2019.04.022.
[26]
Mazzocchi A, Giannì ML, Morniroli D, et al. Hormones in breast milk and effect on infants′ growth: a systematic review[J]. Nutrients, 2019, 11(8): 1845. DOI: 10.3390/nu11081845.
[27]
Çaǧiran Yilmaz F, Özçelik . The relationships between leptin levels in maternal serum and breast milk of mothers and term infants[J]. Ann Med, 2021, 53(1): 1309-1315. DOI: 10.1080/07853890.2021.1964037.
[28]
Dündar NO, Dündar B, Cesur G, et al. Ghrelin and adiponectin levels in colostrum, cord blood and maternal serum[J]. Pediatr Int, 2010, 52(4): 622-625. DOI: 10.1111/j.1442-200X.2010.03100.x.
[29]
Woo JG, Guerrero ML, Altaye M, et al. Human milk adiponectin is associated with infant growth in two independent cohorts[J]. Breastfeed Med, 2009, 4(2): 101-109. DOI: 10.1089/bfm.2008.0137.
[30]
Chan D, Goruk S, Becker AB, et al. Adiponectin, leptin and insulin in breast milk: associations with maternal characteristics and infant body composition in the first year of life[J]. Int J Obesity (Lond), 2018, 42(1): 36-43. DOI: 10.1038/ijo.2017.189.
[31]
Sahin S, Ozdemir T, Katipoglu N, et al. Comparison of changes in breast milk macronutrient content during the first month in preterm and term infants[J]. Breastfeed Med, 2020, 15(1): 56-62. DOI: 10.1089/bfm.2019.0141.
[32]
吴夏萍,何必子,刘登礼,等. 探讨母乳喂养对早产儿肺功能发育的影响分析[J]. 当代医学2021, 27(29): 66-69. DOI: 10.3969/j.issn.1009-4393.2021.29.026.
[33]
王丹华,刘喜红. 早产、低出生体重儿出院后喂养建议[J]. 中华儿科杂志2016, 54(1): 6-12. DOI: 10.3760/cma.j.issn.0578-1310.2016.01.003.
[34]
Quan MY, Wang DH, Gou LJ, et al. Individualized human milk fortification to improve the growth of hospitalized preterm infants[J]. Nutr Clin Pract, 2020, 35(4): 680-688. DOI: 10.1002/ncp.10366.
[1] 刘嘉嘉, 王承华, 陈绪娇, 刘瑗玲, 王善钰, 屈海花, 张莉. 经阴道子宫-输卵管实时三维超声造影中患者疼痛发生情况及其影响因素分析[J]. 中华医学超声杂志(电子版), 2023, 20(09): 959-965.
[2] 高玲, 于哲, 范然, 臧银善. 外周血细胞计数比值评估类风湿关节炎疗效的价值[J]. 中华关节外科杂志(电子版), 2023, 17(05): 642-647.
[3] 王蓓蓓, 董启秀, 郗红燕, 于庆云, 张丽君, 式光. 早孕期孕妇药物流产失败的影响因素分析与构建相关预测模型及其对药物流产成功的预测价值[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 588-594.
[4] 陈絮, 詹玉茹, 王纯华. 孕妇ABO血型联合甲状腺功能检测对预测妊娠期糖尿病的临床价值[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 604-610.
[5] 胡诤贇, 史建伟, 申建伟, 王冰, 蒋春苗, 刘冲. 基于机器学习鉴定早产儿支气管肺发育不良的关键基因[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(04): 446-454.
[6] 王鹏, 肖厚安, 贾赤宇. 不同因素调控巨噬细胞极化在慢性难愈性创面中的研究进展[J]. 中华损伤与修复杂志(电子版), 2023, 18(05): 454-459.
[7] 杨倩, 李翠芳, 张婉秋. 原发性肝癌自发性破裂出血急诊TACE术后的近远期预后及影响因素分析[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 33-36.
[8] 甄子铂, 刘金虎. 基于列线图模型探究静脉全身麻醉腹腔镜胆囊切除术患者术后肠道功能紊乱的影响因素[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 61-65.
[9] 黄汇, 朱信强. 131I治疗45岁以下分化型甲状腺癌的疗效及影响因素[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 627-630.
[10] 王帆, 马秋月, 刘小莉. 基于分位数回归模型的切口疝手术患者住院费用影响因素分析[J]. 中华疝和腹壁外科杂志(电子版), 2023, 17(05): 522-529.
[11] 顾娇娇, 邹燕, 陈奕辰, 黄师菊, 张慧玲, 林楠. 基于简易营养评价精法评估肝癌患者出院后营养状况及其影响因素[J]. 中华肝脏外科手术学电子杂志, 2023, 12(05): 534-539.
[12] 杨静, 顾红叶, 赵莹莹, 孙梦霞, 查园园, 王琪. 老年血液透析患者短期死亡的影响因素及列线图预测模型的预测作用[J]. 中华肾病研究电子杂志, 2023, 12(05): 254-259.
[13] 程莉, 章晓良. 血尿酸和胱抑素C与糖尿病视网膜病变患者合并糖尿病肾病的关系及影响因素[J]. 中华肾病研究电子杂志, 2023, 12(04): 194-199.
[14] 刘代江, 蒋俊艳, 万晓强, 马莎英. 结直肠癌肝转移患者生存状况及预后影响因素分析[J]. 中华消化病与影像杂志(电子版), 2023, 13(05): 284-288.
[15] 杜振双, 胡清福, 林颖艺, 张月霞, 陈美丽, 李祎祺, 王振华. 社区全科医师激励机制的影响因素分析[J]. 中华临床医师杂志(电子版), 2023, 17(08): 876-883.
阅读次数
全文


摘要