切换至 "中华医学电子期刊资源库"

中华妇幼临床医学杂志(电子版) ›› 2022, Vol. 18 ›› Issue (04) : 387 -392. doi: 10.3877/cma.j.issn.1673-5250.2022.04.003

专题论坛

内脏利什曼病临床药物治疗研究现状
袁传杰, 杨雪, 朱渝()   
  1. 四川大学华西第二医院儿科、出生缺陷与相关妇儿疾病教育部重点实验室,成都 610041
  • 收稿日期:2021-12-01 修回日期:2022-05-09 出版日期:2022-08-01
  • 通信作者: 朱渝

Current research status of clinical pharmaceutical treatment options for visceral Leishmaniasis

Chuanjie Yuan, Xue Yang, Yu Zhu()   

  1. Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2021-12-01 Revised:2022-05-09 Published:2022-08-01
  • Corresponding author: Yu Zhu
  • Supported by:
    Project of Science & Technology Department of Sichuan Province(2022YFS0243)
引用本文:

袁传杰, 杨雪, 朱渝. 内脏利什曼病临床药物治疗研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2022, 18(04): 387-392.

Chuanjie Yuan, Xue Yang, Yu Zhu. Current research status of clinical pharmaceutical treatment options for visceral Leishmaniasis[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2022, 18(04): 387-392.

内脏利什曼病(VL)又被称为黑热病,是人体被利什曼原虫感染所致的播散性原虫病。VL患者的临床表现包括长期发热,肝、脾大,全血细胞减少及进行性贫血与消瘦等。我国治疗VL的临床药物以5价锑剂为主。目前临床治疗VL可供选择的药物种类少。笔者拟就VL患者药物治疗方案的最新研究进展进行阐述,旨在为该病患者的临床治疗提供参考。

Visceral Leishmaniasis (VL), also known as Kala-Azar, is a disseminated protozoal infection disease caused by Leishmania. Clinical manifestations of VL patients include chronic fever, hepatosplenomegaly, pancytopenia, progressive anemia and emaciation, etc.. In China, penta-valent antimony is the main treatment option for VL patients. At present, there are a few kinds of medicine available for clinical treatment of VL. This article focuses on review latest research progresses of clinical treatment for VL patients so as to provide reference for physicians.

[1]
Burza S, Croft SL, Boelaert M. Leishmaniasis [J]. Lancet, 2018, 392(10151): 951-970. DOI: 10.1016/S0140-6736(18)31204-2.
[2]
韩帅,伍卫平,薛垂召,等. 2004—2016年中国内脏利什曼病疫情分析[J]. 中国寄生虫学与寄生虫病杂志2019, 37(2): 189-195. DOI: 10.12140/j.issn.1000-7423.2019.02.013.
[3]
Kip AE, Schellens JHM, Beijnen JH, et al. Clinical pharmacokinetics of systemically administered antileishmanial drugs [J]. Clin Pharmacokinet, 2018, 57(2): 151-176. DOI: 10.1007/s40262-017-0570-0.
[4]
霍娜,翁浩宇,李俊,等. 两性霉素B成功治疗黑热病1例报告[J]. 中国实用内科杂志2017, 37(4): 366-368. DOI: 10.19538/j.nk2017040123.
[5]
袁传杰,朱渝. 两性霉素B脂质体治疗儿童耐锑剂黑热病1例并文献复习[J]. 临床儿科杂志2017, 35(4): 307-310. DOI: 10.3969/j.issn.1000-3606.2017.04.017.
[6]
Sundar S, Singh A. Recent developments and future prospects in the treatment of visceral Leishmaniasis[J]. Ther Adv Infect Dis, 2016, 3(3-4): 98-109. DOI: 10.1177/2049936116646063.
[7]
World Health Organization. Control of the Leishmaniases [J]. World Health Organ Tech Rep Ser, 2010, (949): 1-186.
[8]
Aronson N, Herwaldt BL, Libman M, et al. Diagnosis and treatment of Leishmaniasis: clinical practice guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH) [J]. Clin Infect Dis, 2016, 63(12): 1539-1557. DOI: 10.1177/2049936116646063.
[9]
张富南,张丽萍. 四川省黑热病复发和死亡原因分析[J]. 预防医学情报杂志2010, 26(12): 961-965.
[10]
何芳. 儿童黑热病46例临床分析[J].临床儿科杂志2017, 35(3): 191-194. DOI: 10.3969/j.issn.1000-3606.2017.03.009.
[11]
Sundar S, Chakravarty J. An update on pharmacotherapy for Leishmaniasis [J]. Exp Opin Pharmacother, 2015, 16(2): 237-252. DOI: 10.1517/14656566.2015.973850.
[12]
Hasnain MG, Nath P, Maruf S, et al. Amphotericin B deoxycholate for relapse visceral Leishmaniasis in Bangladesh: a cross-sectional study [J]. BMC Res Notes, 2018, 11(1): 918. DOI: 10.1186/s13104-018-4036-8.
[13]
Sundar S, Agarwal D. Visceral Leishmaniasis-optimum treatment options in children [J]. Pediatr Infect Dis J, 2018, 37(5): 492-494. DOI: 10.1097/INF.0000000000001885.
[14]
Sundar S, Singh A, Rai M, et al. Single-dose indigenous liposomal amphotericin B in the treatment of Indian visceral Leishmaniasis: a phase 2 study [J]. Am J Trop Med Hyg, 2015, 92(3): 513-517. DOI: 10.4269/ajtmh.14-0259.
[15]
Pandey K, Pal B, Siddiqui NA, et al. Efficacy and safety of liposomal amphotericin B for visceral Leishmaniasis in children and adolescents at a Tertiary Care Center in Bihar, India[J]. Am J Trop Med Hyg, 2017, 97(5): 1498-1502. DOI: 10.4269/ajtmh.17-0094.
[16]
Mondal D, Alvar J, Hasnain MG, et al. Efficacy and safety of single-dose liposomal amphotericin B for visceral Leishmaniasis in a rural public hospital in Bangladesh: a feasibility study [J]. Lancet Glob Health, 2014, 2(1): e51-e57. DOI: 10.1016/S2214-109X(13)70118-9.
[17]
Burza S, Sinha PK, Mahajan R, et al. Five-year field results and long-term effectiveness of 20 mg/kg liposomal amphotericin B (ambisome) for visceral Leishmaniasis in Bihar, India [J]. PLoS Negl Trop Dis, 2014, 8(1): e2603. DOI: 10.1371/journal.pntd.0002603.
[18]
Krepis P, Argyri I, Krepi A, et al. Short-course regimens of liposomal amphotericin B for the treatment of mediterranean visceral Leishmaniasis in children: an 11-year retrospective study at a Tertiary Care Center [J]. Pediatr Infect Dis J, 2017, 36(9): 849-854. DOI: 10.1097/INF.0000000000001602.
[19]
Jamil KM, Haque R, Rahman R, et al. Effectiveness study of paromomycin IM injection (PMIM) for the treatment of visceral Leishmaniasis (VL) in Bangladesh [J]. PLoS Negl Trop Dis2015, 9(10): e0004118. DOI: 10.1371/journal.pntd.0004118.
[20]
Hailu A, Musa A, Wasunna M, et al. Geographical variation in the response of visceral Leishmaniasis to paromomycin in East Africa: a multicentre, open-label, randomized trial [J]. PLoS Negl Trop Dis, 2010, 4(10): e709. DOI: 10.1371/journal.pntd.0000709.
[21]
Hendrickx S, Mondelaers A, Eberhardt E, et al. In vivo selection of paromomycin and miltefosine resistance in Leishmania donovani and L. infantum in a Syrian hamster model [J]. Antimicrob Agents Chemother, 2015, 59(8): 4714-4718. DOI: 10.1128/AAC.00707-15.
[22]
Mbui J, Olobo J, Omollo R, et al. Pharmacokinetics, safety, and efficacy of an allometric miltefosine regimen for the treatment of visceral Leishmaniasis in Eastern African children: an open-label, phase Ⅱ clinical trial [J]. Clin Infect Dis, 2019, 68(9): 1530-1538. DOI: 10.1093/cid/ciy747.
[23]
Diro E, Ritmeijer K, Boelaert M, et al. Use of pentamidine as secondary prophylaxis to prevent visceral Leishmaniasis relapse in HIV infected patients, the first twelve months of a prospective cohort study [J]. PLoS Negl Trop Dis, 2015, 9(10): e0004087. DOI: 10.1371/journal.pntd.0004087.
[24]
van Griensven J, Diro E. Visceral Leishmaniasis: recent advances in diagnostics and treatment regimens [J]. Infect Dis Clin North Am, 2019, 33(1): 79-99. DOI: 10.1016/j.idc.2018.10.005.
[25]
Sundar S, Sinha PK, Rai M, et al. Comparison of short-course multidrug treatment with standard therapy for visceral Leishmaniasis in India: an open-label, non-inferiority, randomised controlled trial [J]. Lancet, 2011, 377(9764): 477-486. DOI: 10.1016/S0140-6736(10)62050-8.
[26]
Rahman R, Goyal V, Haque R, et al. Safety and efficacy of short course combination regimens with AmBisome, miltefosine and paromomycin for the treatment of visceral Leishmaniasis (VL) in Bangladesh [J]. PLoS Negl Trop Dis, 2017, 11(5): e0005635. DOI: 10.1371/journal.pntd.0005635.
[27]
Kimutai R, Musa AM, Njoroge S, et al. Safety and effectiveness of sodium stibogluconate and paromomycin combination for the treatment of visceral Leishmaniasis in Eastern Africa: results from a pharmacovigilance programme [J]. Clin Drug Investig, 2017, 37(3): 259-272. DOI: 10.1007/s40261-016-0481-0.
[28]
Diro E, Lynen L, Mohammed R, et al. High parasitological failure rate of visceral Leishmaniasis to sodium stibogluconate among HIV co-infected adults in Ethiopia[J]. PLoS Negl Trop Dis, 2014, 8(5): e2875. DOI: 10.1371/journal.pntd.0002875.
[29]
Monge-Maillo B, López-Vélez R. Treatment options for visceral Leishmaniasis and HIV coinfection[J]. AIDS Rev, 201618(1): 32-43. PMID:26936761.
[30]
Cipriano P, Miranda AC, Antunes I, et al. Visceral Leishmaniasis in HIV-infected patients: the challenge of relapse and treatment failure [J]. Acta Med Port, 2017, 30(6): 443-448. DOI: 10.20344/amp.8291.
[31]
Diro E, Lynen L, Ritmeijer K, et al. Visceral Leishmaniasis and HIV coinfection in East Africa[J]. PLoS Negl Trop Dis, 2014, 8(6): e2869. DOI:10.1371/journal.pntd.0002869.
[32]
Mahajan R, Das P, Isaakidis P, et al. Combination treatment for visceral Leishmaniasis patients coinfected with human immunodeficiency virus in India [J]. Clin Infect Dis, 2015, 61(8): 1255-1262. DOI: 10.1016/j.ijid.2016.02.166.
[33]
Abongomera C, Diro E, de Lima Pereira A, et al. The initial effectiveness of liposomal amphotericin B (ambisome) and miltefosine combination for treatment of visceral Leishmaniasis in HIV co-infected patients in Ethiopia: a retrospective cohort study[J]. PLoS Negl Trop Dis, 2018, 12(5): e0006527. DOI:10.1371/journal.pntd.0006527.
[34]
Diro E, Blesson S, Edwards T, et al. A randomized trial of ambisome monotherapy and ambisome and miltefosine combination to treat visceral Leishmaniasis in HIV co-infected patients in Ethiopia [J]. PLoS Negl Trop Dis, 2019, 13(1): e0006988. DOI: 10.1371/journal.pntd.0006988.
[35]
Diro E, Edwards T, Ritmeijer K, et al. Long term outcomes and prognostics of visceral Leishmaniasis in HIV infected patients with use of pentamidine as secondary prophylaxis based on CD4 level: a prospective cohort study in Ethiopia [J]. PLoS Negl Trop Dis, 2019, 13(2): e0007132. DOI: 10.1371/journal.pntd.0007132.
[1] 陶宏宇, 叶菁菁, 俞劲, 杨秀珍, 钱晶晶, 徐彬, 徐玮泽, 舒强. 右心声学造影在儿童右向左分流相关疾病中的评估价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(10): 959-965.
[2] 刘琴, 刘瀚旻, 谢亮. 基质金属蛋白酶在儿童哮喘发生机制中作用的研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 564-568.
[3] 向韵, 卢游, 杨凡. 全氟及多氟烷基化合物暴露与儿童肥胖症相关性研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 569-574.
[4] 王雅楠, 刘丹, 曹正浓, 贾慧敏. 儿童迟发性先天性膈疝患儿的临床诊治特点分析[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(04): 410-419.
[5] 陈桂华, 钟小玲, 谢雨, 王慧, 谢江, 杨涛毅. 合并肝脏疾病特殊健康状态儿童疫苗预防接种及时性临床分析[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(04): 431-439.
[6] 刘冉佳, 崔向丽, 周效竹, 曲伟, 朱志军. 儿童肝移植受者健康相关生存质量评价的荟萃分析[J/OL]. 中华移植杂志(电子版), 2024, 18(05): 302-309.
[7] 丁荷蓓, 王珣, 陈为国. 七氟烷吸入麻醉与异丙酚静脉麻醉在儿童腹股沟斜疝手术中的应用比较[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(05): 570-574.
[8] 曾纪晓, 徐晓钢, 王欣星, 刘斐, 兰梦龙, 陶波圆, 梁子建, 叶志华, 罗媛圆. 达芬奇机器人辅助Swenson-like巨结肠根治术[J/OL]. 中华腔镜外科杂志(电子版), 2024, 17(04): 239-243.
[9] 中华医学会器官移植学分会, 中华医学会外科学分会外科手术学学组, 中华医学会外科学分会移植学组, 华南劈离式肝移植联盟. 劈离式供肝儿童肝移植中国临床操作指南[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 593-601.
[10] 刘军, 丘文静, 孙方昊, 李松盈, 易述红, 傅斌生, 杨扬, 罗慧. 在体与离体劈离式肝移植在儿童肝移植中的应用比较[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 688-693.
[11] 张佳臣, 宋红欣. 儿童青少年等效球镜屈光度变化与屈光不正进展相关性的临床研究[J/OL]. 中华眼科医学杂志(电子版), 2024, 14(04): 217-222.
[12] 张琛, 秦鸣, 董娟, 陈玉龙. 超声检查对儿童肠扭转缺血性改变的诊断价值[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 565-568.
[13] 王晓瑜, 郭群英, 牛雅萌, 赵成松. 公立儿童医院促进儿科就医均等化实践探析[J/OL]. 中华临床医师杂志(电子版), 2024, 18(04): 383-387.
[14] 陈晓胜, 何佳, 刘方, 吴蕊, 杨海涛, 樊晓寒. 直立倾斜试验诱发31 秒心脏停搏的植入心脏起搏器儿童一例并文献复习[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(05): 488-494.
[15] 曹亚丽, 高雨萌, 张英谦, 李博, 杜军保, 金红芳. 儿童坐位不耐受的临床进展[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(05): 510-515.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?