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中华妇幼临床医学杂志(电子版) ›› 2022, Vol. 18 ›› Issue (02) : 125 -131. doi: 10.3877/cma.j.issn.1673-5250.2022.02.001

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液体活检在新生儿脑损伤诊断及预后判断中的应用和展望
刘仕茜, 屈艺(), 应俊杰, 母得志   
  1. 四川大学华西第二医院儿科、出生缺陷与相关妇儿疾病教育部重点实验室,成都 610041
  • 收稿日期:2021-12-30 修回日期:2022-03-21 出版日期:2022-04-01
  • 通信作者: 屈艺

Application and prospect of liquid biopsy in diagnosis and prognostic evaluation of neonatal brain injury

Shixi Liu, Yi Qu(), Junjie Ying, Dezhi Mu   

  1. Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University), Ministry of Education, West China Second University Hospital, Chengdu 610041, Sichuan Province, China
  • Received:2021-12-30 Revised:2022-03-21 Published:2022-04-01
  • Corresponding author: Yi Qu
  • Supported by:
    National Natural Science Foundation of China(81701500, 81771634, 81971428)
引用本文:

刘仕茜, 屈艺, 应俊杰, 母得志. 液体活检在新生儿脑损伤诊断及预后判断中的应用和展望[J]. 中华妇幼临床医学杂志(电子版), 2022, 18(02): 125-131.

Shixi Liu, Yi Qu, Junjie Ying, Dezhi Mu. Application and prospect of liquid biopsy in diagnosis and prognostic evaluation of neonatal brain injury[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2022, 18(02): 125-131.

液体活检(LB)是一种利用人体体液获取疾病诊治相关信息的技术,已在多个领域,尤其是肿瘤诊治领域广泛开展,并取得突破性进展。LB在新生儿脑损伤,如颅内出血、新生儿缺氧缺血性脑损伤(HIBD)及早产儿脑白质损伤等诊断中的应用已有开展。笔者拟就LB在新生儿脑损伤诊断及预后判断中的优势、应用现状等最新研究进展进行阐述,旨在为临床对新生儿脑损伤的诊断及预后判断提供参考。

Liquid biopsies (LB), a technique using human body fluids to obtain disease information, has been widely carried out in multiple fields and made breakthrough progress, especially in tumor diagnosis and treatment. The application of LB has been developed in the diagnosis of neonatal brain injury, such as intracranial hemorrhage, neonatal hypoxic-ischemic brain damage (HIBD), and brain white matter injury in preterm infants. We intend to describe the latest research progresses of advantages and current application statuses of LB in diagnosis and prognosis evaluation of neonatal brain injury, in order to provide reference for clinical diagnosis and prognosis evaluation of neonatal brain injury.

表1 外泌体生物标志物与神经系统疾病诊断的关系
表2 目前临床用于新生儿脑损伤诊断中,主要涉及的相关游离血液生物标志物
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