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中华妇幼临床医学杂志(电子版) ›› 2021, Vol. 17 ›› Issue (05) : 510 -515. doi: 10.3877/cma.j.issn.1673-5250.2021.05.003

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口腔菌群与儿童常见非口腔性疾病的关系
杨蕾1,1, 肖东琼2,2, 钟亦思3,,3()   
  • 收稿日期:2021-04-11 修回日期:2021-09-22 出版日期:2021-10-01
  • 通信作者: 钟亦思

Current research status between oral microbiome and common non-oral diseases in children

Lei Yang1,1, Dongqiong Xiao2,2, Yisi Zhong3,3,()   

  • Received:2021-04-11 Revised:2021-09-22 Published:2021-10-01
  • Corresponding author: Yisi Zhong
  • Supported by:
    Basic Appiled Research Project of Science and Technology Department of Sichuan Province(2021YJ0229)
引用本文:

杨蕾, 肖东琼, 钟亦思. 口腔菌群与儿童常见非口腔性疾病的关系[J/OL]. 中华妇幼临床医学杂志(电子版), 2021, 17(05): 510-515.

Lei Yang, Dongqiong Xiao, Yisi Zhong. Current research status between oral microbiome and common non-oral diseases in children[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2021, 17(05): 510-515.

口腔处于人体消化道的最上游,有许多截然不同的微环境,亦是病原体进入人体的主要途径之一。与成年人相比,儿童口腔正常菌群随着生长发育而处于动态变化中,对外界刺激也更为敏感。儿童口腔菌群异常变化,与多种疾病的发生、发展密切相关。因此,通过口腔对儿童进行非侵入性生物样品采集,对某些疾病的快速辅助诊断具有重要意义。笔者拟就儿童口腔菌群的建立及其特点,以及近年对口腔菌群异常变化在儿童哮喘、过敏性紫癜(HSP)、肥胖、阑尾炎和炎症性肠病(IBD)等常见疾病中作用的最新研究进展进行阐述,旨在为儿童非口腔性疾病的辅助诊断提供参考。

Oral cavity is at the uppermost part of human digestive tract. There are many distinct microenvironments in oral cavity, and oral cavity is the main way for pathogens to enter human body. Compared with adults, the oral microbiome in children changes dynamically with body′s growth, and it is more sensitive to external stimulation. The abnormal changes of oral microbiome in children are closely related to occurrence and development of a variety of diseases. Therefore, non-invasive biological samples can be collected through oral cavity to assist in immediate detection and rapid diagnosis of some diseases for children, and it is of great significance. This article summarizes establishment and characteristics of children′s oral microbiome, focuses on research advances in relationship between oral microbiome and children′s some non-oral diseases in recent years, including asthma, Henoch-Schonlein purpura (HSP), obesity, appendicitis and inflammatory bowel disease (IBD), in order to provide evidences for auxiliary diagnosis of children′s some non-oral diseases.

表1 与儿童哮喘相关的口腔菌群
表2 与过敏性紫癜患儿相关的口腔菌群
表3 与儿童肥胖相关的口腔菌群
表4 与阑尾炎患儿相关的口腔菌群
表5 与炎症性肠病患儿相关的口腔菌群
[1]
Xiao J, Fiscella KA, Gill SR.Oral microbiome: possible harbinger for children′s health[J]. Int J Oral Sci, 2020, 12(1): 12. DOI: 10.1038/s41368-020-0082-x.
[2]
Verma D, Garg PK, Dubey AK. Insights into the human oral microbiome[J]. Arch Microbiol, 2018, 200(4): 525-540. DOI: 10.1007/s00203-018-1505-3.
[3]
Yumoto HHK, Hirao K, Ninomiya M, et al. The pathogenic factors from oral Streptococci for systemic diseases[J]. Int J Mol Sci, 2019, 20(18): 4571. DOI: 10.3390/ijms20184571.
[4]
Willis JR, Gabaldón T. The human oral microbiome in health and disease: from sequences to ecosystems[J]. Microorganisms, 2020, 8(2): 308. DOI: 10.3390/microorganisms8020308.
[5]
Xun Z, Zhang Q, Xu T, et al. Dysbiosis and ecotypes of the salivary microbiome associated with inflammatory bowel diseases and the assistance in diagnosis of diseases using oral bacterial profiles[J]. Front Microbiol, 2018, 9: 1136. DOI: 10.3389/fmicb.2018.01136.
[6]
Bäckhed F, Roswall J, Peng Y, et al. Dynamics and stabilization of the human gut microbiome during the first year of life[J]. Cell Bost Microbe, 2015, 17(5): 690-703. DOI: 10.1016/j.chom.2015.04.004.
[7]
Fakhruddin KS, Ngo HC, Samaranayake LP. Cariogenic microbiome and microbiota of the early primary dentition: a contemporary overview[J]. Oral Dis, 2019, 25(4): 982-995. DOI: 10.1111/odi.12932.
[8]
Silva MJ, Riggs E, Kilpatrick NM. Getting ahead of the oral health game: it starts before we′re born?[J]. Aust Dent J, 2019, 64(Suppl 1): S4-S9. DOI: 10.1111/adj.12672.
[9]
Amir M, Brown JA, Rager SL, et al. Maternal microbiome and infections in pregnancy[J]. Microorganisms, 2020, 8(12): 1996. DOI: 10.3390/microorganisms8121996.
[10]
邹静,周学东. 儿童口腔正常微生物群早期定植研究概述[J]. 中华儿科杂志2003, 41(3): 193-195. DOI: 10.3760/cma.j.issn.0578-1310.2003.03.116.
[11]
Nardi GM, Grassi R, Ndokaj A, et al. Maternal and neonatal oral microbiome developmental patterns and correlated factors: a systematic review-does the apple fall close to the tree?[J]. Int J Environ Health Res, 2021, 18(11): 5569. DOI: 10.3390/ijerph18115569.
[12]
Gomez A, Nelson KE. The oral microbiome of children: development, disease, and implications beyond oral health[J]. Microb Ecol, 2017, 73(2): 492-503. DOI: 10.1007/s00248-016-0854-1.
[13]
Dzidic M, Abrahamsson TR, Artacho A, et al. Oral microbiota maturation during the first 7 years of life in relation to allergy development[J]. Allergy, 2018, 73(10): 2000-2011. DOI: 10.1111/all.13449.
[14]
Ahn J, Chen CY, Hayes RB. Oral microbiome and oral and gastrointestinal cancer risk[J]. Can Caus Control, 2012, 23(3): 399-404. DOI: 10.1007/s10552-011-9892-7.
[15]
Arafa A, Aldahlawi S, Fathi A. Assessment of the oral health status of asthmatic children[J]. Eur J Gen Dent, 2017, 11(3): 357-363. DOI: 10.4103/ejd.ejd_65_17.
[16]
Rossi GA, Pohunek P, Feleszko W, et al. Viral infections and wheezing-asthma inception in childhood: is there a role for immunomodulation by oral bacterial lysates?[J]. Clin Transl Allergy, 2020, 10: 17. DOI: 10.1186/s13601-020-00322-1.
[17]
Son JH, Kim JH, Chang HS, et al. Relationship of microbial profile with airway immune response in eosinophilic or neutrophilic inflammation of asthmatics[J]. Allerg Asthm Immunol Res, 2020, 12(3): 412-429. DOI: 10.4168/aair.2020.12.3.412.
[18]
Huang YJ, Nariya S, Harris JM, et al. The airway microbiome in patients with severe asthma: associations with disease features and severity[J]. J Investig Allergol Clin Immunol, 2015, 136(4): 874-884. DOI: 10.1016/j.jaci.2015.05.044.
[19]
Hetland LE, Susrud KS, Lindahl KH, et al. Henoch-Schönlein purpura: a literature review[J]. Acta Derm Venereol, 2017, 97(10):1160-1166. DOI: 10.2340/00015555-2733.
[20]
Chen B, Wang J, Wang Y, et al. Oral microbiota dysbiosis and its association with Henoch-Schönlein purpura in children[J]. Int Immunopharmacol, 2018, 65: 295-302. DOI: 10.1016/j.intimp.2018.10.017.
[21]
Xiong LJ, Tong Y, Wang ZL, et al. Is helicobacter pylori infection associated with Henoch-Schonlein purpura in Chinese children? A Meta-analysis[J]. World J Pediatr, 2012, 8(4): 301-308. DOI: 10.1007/s12519-012-0373-1.
[22]
Wang JJ, Xu Y, Liu FF, et al. Association of the infectious triggers with childhood Henoch-Schonlein purpura in Anhui Province, China [J]. J Infect Public Health, 2020, 13(1): 110-117. DOI: 10.1016/j.jiph.2019.07.004.
[23]
Fyhrquist N, Ruokolainen L, Suomalainen A, et al. Acinetobacter species in the skin microbiota protect against allergic sensitization and inflammation[J]. J Clin Lab Immunol, 2014, 134(6): 1301.e11-1309.e11. DOI: 10.1016/j.jaci.2014.07.059.
[24]
Castro E, Edland SD, Lee L, et al. Polymorphisms at the Werner locus: II. 1074Leu/Phe, 1367Cys/Arg, longevity, and atherosclerosis[J]. Am J Med Genet, 2000, 95(4): 374-380. DOI: 10.1002/1096-8628(20001211)95:43.0.CO;2-4.
[25]
Indiani CMSP, Rizzardi KF, Crescente CL, et al. Relationship between mutans Streptococci and Lactobacilli in the oral cavity and intestine of obese and eutrophic children with early childhood caries-preliminary findings of a cross-sectional study[J]. Front Pediatr, 2020, 8: 588965. DOI: 10.3389/fped.2020.588965.
[26]
Araujo DS, Klein MI, Scudine KGO, et al. Salivary microbiological and gingival health status evaluation of adolescents with overweight and obesity: a cluster analysis[J]. Front Pediatr, 2020, 8: 429. DOI: 10.3389/fped.2020.00429.
[27]
Wu Y, Chi X, Zhang Q, et al. Characterization of the salivary microbiome in people with obesity[J]. Peer J, 2018, 6: e4458. DOI: 10.7717/peerj.4458.
[28]
Craig SJC, Blankenberg D, Parodi ACL, et al. Child weight gain trajectories linked to oral microbiota composition[J]. Sci Rep, 2018, 8(1): 14030. DOI: 10.1038/s41598-018-31866-9.
[29]
Roa I, Del Sol M. Obesity, salivary glands and oral pathology[J]. Colomb Med (Cali), 201849(4): 280-287. DOI: 10.25100/cm.v49i3.3919.
[30]
Richardson M, Ren J, Rubinstein MR, et al. Analysis of 16S rRNA genes reveals reduced fusobacterial community diversity when translocating from saliva to GI sites[J]. Gut Microb, 2020, 12(1): 1-13. DOI: 10.1080/19490976.2020.1814120.
[31]
Blod C, Schlichting N, Schülin S, et al. The oral microbiome-the relevant reservoir for acute pediatric appendicitis?[J]. Int J Colorectal Dis, 2018, 33(2): 209-218. DOI: 10.1007/s00384-017-2948-8.
[32]
Bertola EA, Simonetti GD, Del Giorno R, et al. Extrarenal immune-mediated disorders linked with acute poststreptococcal glomerulonephritis: a systematic review[J]. Clin Rev Allergy Immunol, 2019, 57(2): 294-302. DOI: 10.1007/s12016-019-08761-w.
[33]
Tjalsma H, Boleij A, Marchesi JR, et al. A bacterial driver-passenger model for colorectal cancer: beyond the usual suspects[J]. Nat Rev Microbiol, 2012, 10(8): 575-582. DOI: 10.1038/nrmicro2819.
[34]
Gao L, Xu T, Huang G, et al. Oral microbiomes: more and more importance in oral cavity and whole body[J]. Protein Cell, 2018, 9(5): 488-500. DOI: 10.1007/s13238-018-0548-1.
[35]
Atarashi K, Suda W, Luo C, et al. Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation[J]. Science, 2017, 358(6361): 359-365. DOI: 10.1126/science.aan4526.
[36]
Rojas-Feria M, Romero-García T, Caballero-Rico JÁF, et al. Modulation of faecal metagenome in Crohn′s disease: role of microRNAs as biomarkers[J]. World J Gastroenterol, 2018, 24(46): 5223. DOI: 10.3748/wjg.v24.i46.5223.
[37]
Nishino K, Nishida A, Inoue R, et al. Analysis of endoscopic brush samples identified mucosa-associated dysbiosis in inflammatory bowel disease[J]. Gastroenterol, 2018, 53(1): 95-106. DOI: 10.1007/s00535-017-1384-4.
[38]
Dickson I. Oral bacteria: a cause of IBD?[J]. Nat Rev Gastroenterol Hepatol, 2018, 15(1): 4-5. DOI: 10.1038/nrgastro.2017.161.
[39]
Integrative HMP, Proctor LM, Creasy HH, et al. The integrative human microbiome project[J]. Nature, 2019, 569(7758): 641-648. DOI: 10.1038/s41586-019-1238-8.
[40]
Lloyd-Price J, Arze C, Ananthakrishnan AN, et al. Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases[J]. Nature, 2019, 569(7758): 655-662. DOI: 10.1038/s41586-019-1237-9.
[41]
Docktor MJ, Paster BJ, Abramowicz S, et al. Alterations in diversity of the oral microbiome in pediatric inflammatory bowel disease[J]. Inflamm Bowel Dis, 2012, 18(5): 935-942. DOI: 10.1002/ibd.21874.
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