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中华妇幼临床医学杂志(电子版) ›› 2021, Vol. 17 ›› Issue (04) : 373 -379. doi: 10.3877/cma.j.issn.1673-5250.2021.04.001

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早产儿生命早期肺发育轨迹研究现状
张海洋, 刘瀚旻†()   
  • 收稿日期:2021-03-11 修回日期:2021-07-13 出版日期:2021-08-01
  • 通信作者: 刘瀚旻

Current research status on developmental trajectory of lung in premature infants

Haiyang Zhang, Hanmin Liu()   

  • Received:2021-03-11 Revised:2021-07-13 Published:2021-08-01
  • Corresponding author: Hanmin Liu
  • Supported by:
    Key Research and Development Project of Sichuan Science and Technology Department(2019YFS0037)
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张海洋, 刘瀚旻. 早产儿生命早期肺发育轨迹研究现状[J]. 中华妇幼临床医学杂志(电子版), 2021, 17(04): 373-379.

Haiyang Zhang, Hanmin Liu. Current research status on developmental trajectory of lung in premature infants[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2021, 17(04): 373-379.

人体肺发育成熟沿着固定轨迹进行。生命早期的多种影响因素，均可能导致该轨迹发生改变，从而改变患儿呼吸系统的发育结局。早产儿肺功能检测可以动态、准确、无创、早期、重复评估其呼吸系统状态，了解其生命早期肺功能特点。对早产儿肺发育轨迹特点的研究，有助于更好理解其呼吸系统发育规律及向成年人时期肺功能过渡的特点。笔者拟就早产儿肺发育轨迹模式、早产儿肺发育追赶性生长、早产儿生命早期影响因素对肺发育轨迹的影响及其他相关研究等的最新进展进行阐述。

关键词: 呼吸功能试验, 呼吸窘迫综合征, 支气管肺发育不良, 肺疾病，慢性阻塞性, 肺发育轨迹, 婴儿，早产

The development and maturation of human lung follows a fixed trajectory, and a variety of influencing factors in early life may lead to changes in this trajectory, thus changing the developmental outcomes of children′s respiratory system. Lung function test of premature infants can dynamically, accurately, non-invasively, early and repeatedly assess respiratory system status and understand characteristics of lung function in early life. Study on characteristics of premature infants′ lung development trajectory is helpful to better understand their respiratory system development and characteristics of their lung function transition to adult. This paper summarizes the trajectory pattern of premature infants′ lung development, and catch-up growth of premature infants′ lung development, influence factors of early life on trajectory of premature infants′ lung development and maturation, and other related studies.

Key words: Respiratory function tests, Respiratory distress syndrome, Bronchopulmonary dysplasia, Pulmonary disease, chronic obstructive, Lung development trajectory, Infant, premature
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