切换至 "中华医学电子期刊资源库"

中华妇幼临床医学杂志(电子版) ›› 2021, Vol. 17 ›› Issue (02) : 132 -137. doi: 10.3877/cma.j.issn.1673-5250.2021.02.002

所属专题: 文献

专题论坛

子宫内膜异位症与干细胞研究现状
于秀章, 郄明蓉, 侯敏敏()   
  • 收稿日期:2020-11-12 修回日期:2021-03-09 出版日期:2021-04-01
  • 通信作者: 侯敏敏

Current research status of endometriosis and stem cells

Xiuzhang Yu, Mingrong Qie, Minmin Hou()   

  • Received:2020-11-12 Revised:2021-03-09 Published:2021-04-01
  • Corresponding author: Minmin Hou
  • Supported by:
    Scientific Research Project of Sichuan Provincial Health and Family Planning Commission (Key Research Project)(18ZD030)
引用本文:

于秀章, 郄明蓉, 侯敏敏. 子宫内膜异位症与干细胞研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2021, 17(02): 132-137.

Xiuzhang Yu, Mingrong Qie, Minmin Hou. Current research status of endometriosis and stem cells[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2021, 17(02): 132-137.

子宫内膜异位症(EMS)是妇科最常见良性疾病之一,但是其发病机制迄今尚未阐明,对其长期治疗疗效亦不满意。目前,"EMS起源的干细胞学说"为EMS研究提供了新思路。该学说在一定程度上解释了所有类型的EMS起源理论。随着目前对子宫内膜干细胞特性、特异性生物标志物等研究的逐渐深入,揭示参与子宫内膜异位病灶的干细胞,可能来源于子宫内膜、骨髓等,同时发现子宫内膜异位病灶的干细胞生物学特性发生一定改变。基于干细胞的EMS治疗策略研究也取得一定成果,对干细胞进行基因修饰,或抑制干细胞特性、减少子宫内膜来源干细胞和骨髓来源干细胞向子宫内膜异位病灶迁移和移植,为治疗EMS提供了新思路。笔者拟就EMS起源的干细胞学说,EMS的干细胞来源,包括子宫内膜来源的干/祖细胞与骨髓间充质干细胞(BMSC),EMS干细胞的生物学特性及其临床意义4个方面,对干细胞与EMS相关理论及其研究现状进行阐述,旨在为EMS发病机制及诊疗策略研究提供参考。

Endometriosis (EMS) is one of the most common benign diseases in gynecology, but its pathogenesis is not clear so far and long-term effect of treatment is not satisfactory.In recent years, " the stem cell theory of EMS" has provided a new idea for researches of EMS. To some extent, this theory can be accounted for all types theories of origin of EMS. In recent years, studies on the characteristics and specific biological markers of endometrial stem cells have been gradually deepened, revealing that stem cells in ectopic lesions may be derived from endometrium and bone marrow, etc., and the biological characteristics of stem cells in ectopic lesions have changed to some extent.Researches on EMS treatment strategies based on stem cells have also made some achievements.Gene modification of stem cells, or inhibiting the characteristics of stem cells, reducing the migration and of endometrial-derived stem cells and bone marrow-derived stem cells to ectopic lesions, may provide some new ideas for the treatment of EMS.This article mainly elaborates on latest research progresses of theories and researches on stem cells and EMS from the following four aspects: stem cell theory of EMS, stem cell source of EMS, including endometrial-derived stem/progenitor cells and bone marrow mesenchymal stem cells (BMSC), biological characteristics of EMS stem cells and clinical significance in EMS treatment, in order to provide a reference for further study on pathogenesis, diagnosis and treatment strategy of EMS.

[1]
郎景和.对子宫内膜异位症认识的历史、现状与发展[J]. 中国实用妇科与产科杂志,2020, 36(3): 193-196. DOI: 10.19538/j.fk2020030101.
[2]
李林双,章汉旺. 子宫内膜异位症患者的不孕机制和助孕策略研究现状[J/CD].中华妇幼临床医学杂志(电子版),2020,16 (3): 272-277. DOI: 10.3877/cma.j.issn.1673-5250.2020.03.004.
[3]
Lin YH, Chen YH, Chang HY,et al. Chronic niche inflammation in endometriosis-associated infertility: current understanding and future therapeutic strategies[J]. Int J Mol Sci, 2018,19(8): 2385. DOI: 10.3390/ijms19082385.
[4]
Cheng Y, Li L, Wang D,et al. Characteristics of human endometrium-derived mesenchymal stem cells and their tropism to endometriosis[J]. Stem Cells Int,2017, 2017:4794827.DOI: 10.1155/2017/4794827.
[5]
Cousins FL, O DF, Gargett CE. Endometrial stem/progenitor cells and their role in the pathogenesis of endometriosis[J]. Best Pract Res Clin Obstet Gynaecol, 2018, 50: 27-38.DOI:10.1016/j.bpobgyn.2018.01.011.
[6]
Koippallil Gopalakrishnan AR, Kishore U, Madan T. Mesenchymal stem cells: a promising tool for targeted gene therapy of endometriosis[J]. Regen Med, 2017, 12(1):69-76.DOI:10.2217/rme-2016-0084.
[7]
El Sabeh M, Afrin S, Singh B, et al. Uterine stem cells and benign gynecological disorders: role in pathobiology and therapeutic implications[J]. Stem Cell Rev Rep, 2020. DOI: 10.1007/s12015-020-10075-w.
[8]
Laganà AS, Garzon S, Götte M, et al. The pathogenesis of endometriosis:molecular and cell biology insights[J]. Int J Mol Sci, 2019, 20(22): 5615. DOI: 10.3390/ijms20225615.
[9]
Wang Y, Nicholes K, Shih IM. The origin and pathogenesis of endometriosis[J]. Annu Rev Pathol, 2020, 15: 71-95. DOI: 10.1146/annurev-pathmechdis-012419-032654.
[10]
Berebichez-Fridman R, Montero-Olvera PR. Sources and clinical applications of mesenchymal stem cells: state-of-the-art review[J]. Sultan Qaboos Univ Med J,2018, 18(3):e264-e277.DOI: 10.18295/squmj.2018.18.03.002.
[11]
Simoni M, Taylor HS. Therapeutic strategies involving uterine stem cells in reproductive medicine[J]. Curr Opin Obstet Gynecol, 2018, 30(3):209-216.DOI: 10.1097/GCO.0000000000000457.
[12]
Gargett CE, Schwab KE, Deane JA. Endometrial stem/progenitor cells: the first 10 years[J]. Hum Reprod Update, 2016, 22(2):137-163.DOI: 10.1093/humupd/dmv051.
[13]
Sasson IE, Taylor HS. Stem cells and the pathogenesis of endometriosis[J]. Ann N Y Acad Sci, 2008, 1127:106-115.DOI:10.1196/annals.1434.014.
[14]
Tempest N, Maclean A, Hapangama DK. Endometrial stem cell markers: current concepts and unresolved questions[J]. Int J Mol Sci, 2018, 19(10): 3240. DOI: 10.3390/ijms19103240.
[15]
Pluchino N, Taylor HS. Endometriosis and stem cell trafficking[J]. Reprod Sci,2016, 23(12):1616-1619.DOI: 10.1177/1933719116671219.
[16]
Santamaria X, Mas A, Cervelló I, et al. Uterine stem cells: from basic research to advanced cell therapies[J]. Hum Reprod Update, 2018, 24(6):673-693.DOI: 10.1093/humupd/dmy028.
[17]
Ong YR, Cousins FL, Yang X, et al. Bone marrow stem cells do not contribute to endometrial cell lineages in chimeric mouse models[J]. Stem Cells, 2018, 36(1): 91-102. DOI: 10.1002/stem.2706.
[18]
Li F, Alderman MH3rd, Tal A, et al. Hematogenous dissemination of mesenchymal stem cells from endometriosis[J]. Stem Cells, 2018, 36(6):881-890.DOI: 10.1002/stem.2804.
[19]
Moridi I, Mamillapalli R, Cosar E. Bone marrow stem cell chemotactic activity is induced by elevated CXCL12 in endometriosis[J]. Reprod Sci, 2017, 24(4):526-533.DOI: 10.1177/1933719116672587.
[20]
Zhang W, Li X, Li H, et al. 17β-estradiol promotes bone marrow mesenchymal stem cell migration mediated by chemokine upregulation[J]. Biochem Biophys Res Commun, 2020, 530(2): 381-388. DOI: 10.1016/j.bbrc.2020.07.135.
[21]
Chen P, Mamillapalli R, Habata S, et al. Endometriosis cell proliferation induced by bone marrow mesenchymal stem cells[J]. Reprod Sci, 2021, 8(2): 426-434. DOI: 10.1007/s43032-020-00294-4.
[22]
Nguyen HPT, Xiao L, Deane JA, et al. N-cadherin identifies human endometrial epithelial progenitor cells by in vitro stem cell assays[J]. Hum Reprod,2017, 32(11):2254-2268.DOI: 10.1093/humrep/dex289.
[23]
Esfandyari S, Chugh RM, Park HS, et al. Mesenchymal stem cells as a bio organ for treatment of female infertility[J]. Cells, 2020, 9(10): 2253. DOI: 10.3390/cells9102253.
[24]
Zhou X, Xu B, Zhang D, et al. Loss of CDYL results in suppression of CTNNB1 and decreased endometrial receptivity[J]. Front Cell Dev Biol,2020, 8:105.DOI: 10.3389/fcell.2020.00105.
[25]
Liu Y, Liang S, Yang F, et al. Biological characteristics of endometriotic mesenchymal stem cells isolated from ectopic lesions of patients with endometriosis[J]. Stem Cell Res Ther, 2020, 11(1): 346. DOI: 10.1186/s13287-020-01856-8.
[26]
Susheelamma CJ, Pillai SM, Asha Nair S. Oestrogen, progesterone and stem cells: the discordant trio in endometriosis?[J]. Expert Rev Mol Med,2018, 20:e2.DOI: 10.1017/erm.2017.13.
[27]
Abdel-Rasheed M, Nour Eldeen G, Mahmoud M, et al. MicroRNA expression analysis in endometriotic serum treated mesenchymal stem cells[J]. EXCLI J, 2017, 16: 852-867. DOI: 10.17179/excli2017-101.
[28]
Anglesio MS, Papadopoulos N, Ayhan A, et al. Cancer-associated mutations in endometriosis without cancer[J]. N Engl J Med, 2017, 376(19): 1835-1848. DOI: 10.1056/NEJMoa1614814.
[29]
Savilova AM, Farkhat KN, Yushina MN, et al. Characteristics of multipotent mesenchymal stromal cells isolated from the endometrium and endometriosis lesions of women with malformations of the internal reproductive organs[J]. Bull Exp Biol Med, 2017, 162(4): 539-544.DOI: 10.1007/s10517-017-3656-7.
[30]
Abomaray F, Gidlöf S, Götherström C. Mesenchymal stromal cells are more immunosuppressive in vitro if they are derived from endometriotic lesions than from eutopic endometrium[J]. Stem Cells Int, 2017, 2017:3215962.DOI: 10.1155/2017/3215962.
[31]
Li J, Dai Y, Zhu H, et al. Endometriotic mesenchymal stem cells significantly promote fibrogenesis in ovarian endometrioma through the Wnt/β-catenin pathway by paracrine production of TGF-β1 and Wnt1[J]. Hum Reprod, 2016, 31(6): 1224-1235. DOI: 10.1093/humrep/dew058.
[32]
吴章颖,王厚梅,杨兰,等. 子宫内膜异位症复发药物治疗进展[J]. 世界最新医学信息文摘,2020, 20(22): 30-31.DOI: 10.3969/j.issn.1671-3141.2020.22.014.
[33]
Liu Y, Zhang Z, Yang F, et al. The role of endometrial stem cells in the pathogenesis of endometriosis and their application to its early diagnosis[J]. Biol Reprod, 2020, 102(6): 1153-1159. DOI: 10.1093/biolre/ioaa011.
[34]
Koippallil Gopalakrishnan AR, Pandit H, Metkari SM, et al. Adenoviral vector encoding soluble Flt-1 engineered human endometrial mesenchymal stem cells effectively regress endometriotic lesions in NOD/SCID mice[J]. Gene Ther, 2016, 23(7): 580-591. DOI: 10.1038/gt.2016.30.
[35]
Ersoy GS, Zolbin MM, Cosar E, et al. Medical therapies for endometriosis differentially inhibit stem cell recruitment[J]. Reprod Sci, 2017, 24(6):818-823.DOI: 10.1177/1933719116682879.
[36]
Ramirez Williams L, Brüggemann K, Hubert M, et al. γ-Secretase inhibition affects viability, apoptosis, and the stem cell phenotype of endometriotic cells[J]. Acta Obstet Gynecol Scand, 2019, 98(12): 1565-1574. DOI: 10.1111/aogs.13707.
[37]
Taghizadeh M, Noruzinia M. Lovastatin reduces stemness via epigenetic reprograming of BMP2 and GATA2 in human endometrium and endometriosis[J]. Cell J, 2017, 19(1): 50-64. DOI: 10.22074/cellj.2016.3894.
[38]
Pluchino N, Mamillapalli R, Shaikh S, et al. CXCR4 or CXCR7 antagonists treat endometriosis by reducing bone marrow cell trafficking[J]. J Cell Mol Med, 2020, 24(4): 2464-2474. DOI: 10.1111/jcmm.14933.
[1] 张舒沁, 陈练. 产后宫腔内妊娠物残留的诊断和临床处理[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 493-497.
[2] 石皆春, 范子玉, 邢燕. 不同筛查方法预警宫颈原位腺癌的效能[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 575-581.
[3] 唐丹, 姚晓曦, 杨博文, 薛绍龙, 李梦瑶, 韦柳杏, 郄明蓉. 双肾上腺皮质激素样激酶1对子宫内膜样腺癌患者临床特征的影响[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 582-590.
[4] 刘昌玲, 张金丽, 张志, 李孝建, 汤文彬, 胡逸萍, 陈宾, 谢晓娜. 负载人脂肪干细胞外泌体的甲基丙烯酰化明胶水凝胶对人皮肤成纤维细胞增殖和迁移的影响[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(06): 517-525.
[5] 雷子威, 凌萍, 沈纵, 魏晨如, 朱邦晖, 伍国胜, 孙瑜. 类器官肺损伤疾病模型构建及应用的研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(06): 531-535.
[6] 宋勤琴, 李双汝, 李林, 杜鹃, 刘继松. 间充质干细胞源性外泌体在改善病理性瘢痕中作用的研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(06): 550-553.
[7] 胡启明, 鄢潇, 尤志学, 黄骁昊. 经瘢痕处单孔腹腔镜下切除多病灶腹壁子宫内膜异位症[J/OL]. 中华腔镜外科杂志(电子版), 2024, 17(05): 314-317.
[8] 张蕾, 彭超, 周应芳. 直肠阴道隔子宫内膜异位症腹腔镜手术技巧[J/OL]. 中华腔镜外科杂志(电子版), 2024, 17(05): 257-261.
[9] 傅红兴, 王植楷, 谢贵林, 蔡娟娟, 杨威, 严盛. 间充质干细胞促进胰岛移植效果的研究进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(06): 351-360.
[10] 王大伟, 陆雅斐, 皇甫少华, 陈玉婷, 陈澳, 江滨. 间充质干细胞通过调控免疫机制促进创面愈合的研究进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(06): 361-366.
[11] 刘文竹, 唐窈, 刘付臣. 诱导多潜能干细胞在神经肌肉疾病研究中的应用进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(06): 367-373.
[12] 袁园园, 岳乐淇, 张华兴, 武艳, 李全海. 间充质干细胞在呼吸系统疾病模型中肺组织分布及治疗机制的研究进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(06): 374-381.
[13] 蔡艺丹, 方坚, 张志强, 陈莉, 张世安, 夏磊, 阮梅, 李东良. 经颈静脉肝内门体分流术对肝硬化门脉高压患者肠道菌群及肝功能的影响[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(05): 285-293.
[14] 王俊楠, 刘晔, 李若涵, 叶青松. 间充质干细胞调控肠脑轴治疗神经系统疾病的潜力[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(05): 313-319.
[15] 芦煜, 李振宇, 吴承东, 周仲伍. 肛周子宫内膜异位症一例报告[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(05): 431-434.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?