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中华妇幼临床医学杂志(电子版) ›› 2019, Vol. 15 ›› Issue (01) : 103 -108. doi: 10.3877/cma.j.issn.1673-5250.2019.01.018

所属专题: 文献

综述

心脏发育及心脏病理性重构过程中YAP/TAZ介导的调控机制研究进展
岳鹏1, 华益民1, 周开宇1, 李一飞1, 吴刚1,()   
  1. 1. 四川大学华西第二医院儿科、出生缺陷与相关妇儿疾病教育部重点实验室,成都 610041
  • 收稿日期:2018-09-07 修回日期:2019-01-11 出版日期:2019-02-01
  • 通信作者: 吴刚

YAP/TAZ-mediated regulation mechanism in cardiac development and pathologic remodeling

Peng Yue1, Yimin Hua1, Kaiyu Zhou1, Yifei Li1, Gang Wu1,()   

  1. 1. Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2018-09-07 Revised:2019-01-11 Published:2019-02-01
  • Corresponding author: Gang Wu
  • About author:
    Corresponding author: Wu Gang, Email:
  • Supported by:
    National Natural Science Foundation of China(81570369, 81571515, 81700360); Program for Changjiang Scholars and Innovative Research Team(IRT0935); Science and Technology Pillar Program of Science and Technology Department of Sichuan Province(2016SZ0056)
引用本文:

岳鹏, 华益民, 周开宇, 李一飞, 吴刚. 心脏发育及心脏病理性重构过程中YAP/TAZ介导的调控机制研究进展[J/OL]. 中华妇幼临床医学杂志(电子版), 2019, 15(01): 103-108.

Peng Yue, Yimin Hua, Kaiyu Zhou, Yifei Li, Gang Wu. YAP/TAZ-mediated regulation mechanism in cardiac development and pathologic remodeling[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2019, 15(01): 103-108.

心脏作为对于力学刺激极度敏感的器官,力学应力刺激在心脏发育及心脏病理性重构的过程中具有重要意义。随着近年研究的不断深入,力学信号的传导及相关调控机制越来越受到关注。其中,YAP/TAZ作为一对新近阐明的转录辅助激活因子,将细胞内、外刺激对于心脏的调控联系在一起。已有研究结果证实,YAP/TAZ及相关的Hippo信号通路参与心肌细胞的发育及发展,并且参与心脏病理性重构及多种病理进程。笔者拟对心脏发育和心脏病理性重构中YAP/TAZ介导的调控机制进行综述。

As an organ that is extremely sensitive to mechanical stimulation, mechanical stress stimulation is of great significance in the process of cardiac development and cardiac pathological remodeling. With the deepening of research in recent years, the mechanical signal transmission and related regulatory mechanisms have attracted more and more attention. YAP/TAZ, as a pair of newly clarified co-transcriptional factors, links the regulation of the heart by intracellular and external stimulation. Previous studies showed that YAP/TAZ and related Hippo signaling pathway are involved in the genesis and proliferation of myocardial cells, as well as in cardiac pathological remodeling and various pathological processes. This article reviews YAP/TAZ-mediated regulatory mechanisms in cardiac development and cardiac pathological remodeling.

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