探讨卵巢支持细胞-间质细胞瘤(SLCTs)的临床表现及活组织病理学检查特征，提高临床对该病的认识。

选取2011年1月1日至2017年12月31日，四川大学华西第二医院收治的经术后活组织病理学检查确诊为卵巢SLCTs的6例患者为研究对象，其年龄为24～57岁。采用回顾性分析方法，采集其临床患者资料，并对卵巢SLCTs患者的临床表现、术后活组织病理学检查结果、辅助检查结果、免疫组化结果、治疗及预后进行总结。本研究遵循的程序符合2013年修订的《世界医学协会赫尔辛基宣言》要求。

对纳入研究的6例卵巢SLCTs患者的研究结果显示，①SLCTs均发生于单侧卵巢。术中，2例卵巢SLCTs的瘤体肉眼可见，其余4例肉眼见卵巢外观无明显异常，均为术后活组织病理学检查时，光学显微镜下查见Sertoli-Leydig细胞。②按照国际妇产科联盟(FIGO)临床分期，均为Ⅰ_A期；按照恶性肿瘤的病理分级：Ⅰ级(高分化)为2例，Ⅱ级(中分化)为2例(其中患者2伴睾丸网相似结构)，另2例分化程度不明确而未能分级。③免疫组化结果显示，α-抑制素(inhibin)均呈阳性，4例钙(视)网膜蛋白(CR)呈阳性，3例抗体波形蛋白(VIM)呈阳性，3例CD₉₉呈阳性，3例CD₁₀呈阴性，4例上皮膜抗原(EMA)呈阴性，5例Ki-67均≤5%。④ 2例患者术前睾酮水平均升高，其中1例术后下降至正常。术前超声检查提示5例患者一侧附件占位。⑤手术治疗中，患者2为卵巢中分化SLCTs伴睾丸网相似结构，行患侧附件切除术，术后对其采用BEP(博来霉素＋依托泊苷＋顺铂)联合化疗方案化疗3个疗程。对这6例患者术后随访9～79个月，无一例复发。

卵巢SLCTs极为少见，术前睾酮水平增高结合超声检查结果可予以辅助诊断，术后活组织病理学检查是诊断卵巢SLCTs的"金标准"。卵巢SLCTs的明确诊断，对于手术方案制定及其预后评估具有重要意义。FIGO临床分期较早的卵巢SLCTs患者预后较好。

To investigate the clinical manifestations and pathological features of ovarian Sertoli-Leydig cell tumors (SLCTs), so as to improve the recognition of this disease.

From January 1, 2011 to December 31, 2017, 6 patients with ovarian SLCTs who were diagnosed by pathological examination at the West China Second University Hospital, Sichuan University were selected as the research subjects. Their age ranged from 24 to 57 years old. The clinical data of those 6 patients were collected so as to summarize clinical characteristics, pathological examination results, auxiliary examination results, immunohistochemical results, and the process of diagnosis and treatment of SLCTs by retrospective analysis method. This study met the requirements of the World Medical Association Declaration of Helsinki revised in 2013.

①Among 6 ovarian SLCTs patients, all the tumors occurred in the unilateral ovary. Only 2 cases of the 6 patients had visible tumors to the naked eye during the operation. And the remaining 4 cases, the Sertoli-Keydig cells were observed under the light microscope, without obvious abnormality in appearance. ② Six patients were staged by the International Federation of Obstetrics and Gynecology (FIGO), all in Ⅰ_A phase. There were 2 cases with high differentiation, 2 cases with middle differentiation (patient 2 with reticular component) and 2 cases with unclear degree of differentiation. ③ Immunohistochemical results of 6 patients showed that α-inhibin was positive in 6 patients, calretinin (CR) was positive in 4 patients, vimentin (VIM) was positive in 3 patients, CD₉₉ was positive in 3 patients, CD₁₀ was negative in 3 patients, epithelial membrane antigen (EMA) was negative in 4 patients, and Ki-67≤5% in 5 patients. ④ Testosterone levels increased in two cases before operation and decreased to normal in one case after operation. Among 6 patients, 5 showed adnexa uteri space-occupying by ultrasouad examination. ⑤Among them, patient 2 had ovarian moderately differentiated SLCTs with reticular components, underwent ipsilateral adnexectomy, and received three courses of BEP chemotherapy regimen (bleomycin + etoposide + cisplatin) after surgery. All the patients were followed up for 9 to 79 months, and none of them had recurrence.

Ovarian SLCTs are extremely rare. Preoperative testosterone levels combined with ultrasound examination results can help diagnose. Postoperative biopsy findings are of great significance to the diagnosis, surgical plan, and prognosis of ovarian SLCTs. Patients with earlier FIGO staging have a better prognosis.