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中华妇幼临床医学杂志(电子版) ›› 2018, Vol. 14 ›› Issue (03) : 368 -372. doi: 10.3877/cma.j.issn.1673-5250.2018.03.019

所属专题: 文献

综述

人羊膜治疗早发性卵巢功能不全的研究进展
王大琳1, 张璨2, 邢阿英2, 耿蒙慧2, 韩阁阁2, 甘冬英2   
  1. 1. 225000 江苏,扬州大学医学院妇产科
    2. 116000 辽宁,大连医科大学妇产科
    3. 225000 江苏扬州,苏北人民医院生殖中心
  • 收稿日期:2018-03-04 修回日期:2018-05-10 出版日期:2018-06-01

Research progress of human amniotic membrane in the treatment of premature ovarian insufficiency

Dalin Wang1, Can Zhang2, Aying Xing2, Menghui Geng2, Gege Han2, Dongying Gan2   

  1. 1. Department of Obstetrics and Gynecology, Clinical Medical School of Yangzhou University, Yangzhou 225000, Jiangsu Province, China
    2. Department of Obstetrics and Gynecology, Dalian Medical University, Dalian 116000, Liaoning Province, China
    3. Reproductive Medical Center, Northern Jiangsu People′s Hospital, Yangzhou 225000, Jiangsu Province, China
  • Received:2018-03-04 Revised:2018-05-10 Published:2018-06-01
  • About author:
    Corresponding author: Hu Yanqiu, Email:
引用本文:

王大琳, 张璨, 邢阿英, 耿蒙慧, 韩阁阁, 甘冬英. 人羊膜治疗早发性卵巢功能不全的研究进展[J/OL]. 中华妇幼临床医学杂志(电子版), 2018, 14(03): 368-372.

Dalin Wang, Can Zhang, Aying Xing, Menghui Geng, Gege Han, Dongying Gan. Research progress of human amniotic membrane in the treatment of premature ovarian insufficiency[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2018, 14(03): 368-372.

早发性卵巢功能不全(POI)是指女性在40岁之前卵巢功能衰退的临床综合征,并且以月经紊乱(停经或稀发月经)伴有高促性腺激素和低雌激素为特征,约80% POI患者属于特发性。随着近年癌症诊疗技术的提高,癌症患者接受放、化疗后面临POI的风险。国内外应用干细胞治疗POI,使患者恢复卵巢功能及生育力的研究取得较大进展,这为恢复POI患者内分泌功能及生育功能指出新的方向。干细胞包括骨髓间充质干细胞、脐带间充质干细胞、脂肪间充质干细胞、人羊膜上皮细胞(hAECs)和人羊膜间充质干细胞(hAMSCs)等,干细胞可能通过分化为颗粒细胞或通过旁分泌,为卵母细胞提供微环境和抑制卵泡凋亡达到修复受损卵巢的目的。笔者拟对人羊膜治疗POI的研究进展进行综述。

Premature ovarian insufficiency (POI) is a clinical syndrome characterized by ovarian function decline before 40 years old. About 80% of POI are idiopathic. With the cancer diagnosis and treatment technology improved, the survivors are faced with the increased risk of POI. In recent years, stem cell therapy has obtained some achievements in the restoration of ovarian function at home and abroad. It has brought hope for the recovery of the endocrine function and fertility of POI patients. These stem cells include bone mesenchymal stem cells, umbilical cord mesenchymal stem cells, adipose mesenchymal stem cells, human amniotic epithelial cells (hAECs) and human amniotic mesenchymal stem cells (hAMSCs) and so on. Stem cells may provide microenvironment and inhibit follicle apoptosis by differentiating into granular cell cells or paracrine to restore damaged ovaries. This article mainly reviews research progresses about human amniotic membrane of POI.

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