切换至 "中华医学电子期刊资源库"

中华妇幼临床医学杂志(电子版) ›› 2018, Vol. 14 ›› Issue (03) : 368 -372. doi: 10.3877/cma.j.issn.1673-5250.2018.03.019

所属专题: 文献

综述

人羊膜治疗早发性卵巢功能不全的研究进展
王大琳1, 张璨2, 邢阿英2, 耿蒙慧2, 韩阁阁2, 甘冬英2   
  1. 1. 225000 江苏,扬州大学医学院妇产科
    2. 116000 辽宁,大连医科大学妇产科
    3. 225000 江苏扬州,苏北人民医院生殖中心
  • 收稿日期:2018-03-04 修回日期:2018-05-10 出版日期:2018-06-01

Research progress of human amniotic membrane in the treatment of premature ovarian insufficiency

Dalin Wang1, Can Zhang2, Aying Xing2, Menghui Geng2, Gege Han2, Dongying Gan2   

  1. 1. Department of Obstetrics and Gynecology, Clinical Medical School of Yangzhou University, Yangzhou 225000, Jiangsu Province, China
    2. Department of Obstetrics and Gynecology, Dalian Medical University, Dalian 116000, Liaoning Province, China
    3. Reproductive Medical Center, Northern Jiangsu People′s Hospital, Yangzhou 225000, Jiangsu Province, China
  • Received:2018-03-04 Revised:2018-05-10 Published:2018-06-01
  • About author:
    Corresponding author: Hu Yanqiu, Email:
引用本文:

王大琳, 张璨, 邢阿英, 耿蒙慧, 韩阁阁, 甘冬英. 人羊膜治疗早发性卵巢功能不全的研究进展[J]. 中华妇幼临床医学杂志(电子版), 2018, 14(03): 368-372.

Dalin Wang, Can Zhang, Aying Xing, Menghui Geng, Gege Han, Dongying Gan. Research progress of human amniotic membrane in the treatment of premature ovarian insufficiency[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2018, 14(03): 368-372.

早发性卵巢功能不全(POI)是指女性在40岁之前卵巢功能衰退的临床综合征,并且以月经紊乱(停经或稀发月经)伴有高促性腺激素和低雌激素为特征,约80% POI患者属于特发性。随着近年癌症诊疗技术的提高,癌症患者接受放、化疗后面临POI的风险。国内外应用干细胞治疗POI,使患者恢复卵巢功能及生育力的研究取得较大进展,这为恢复POI患者内分泌功能及生育功能指出新的方向。干细胞包括骨髓间充质干细胞、脐带间充质干细胞、脂肪间充质干细胞、人羊膜上皮细胞(hAECs)和人羊膜间充质干细胞(hAMSCs)等,干细胞可能通过分化为颗粒细胞或通过旁分泌,为卵母细胞提供微环境和抑制卵泡凋亡达到修复受损卵巢的目的。笔者拟对人羊膜治疗POI的研究进展进行综述。

Premature ovarian insufficiency (POI) is a clinical syndrome characterized by ovarian function decline before 40 years old. About 80% of POI are idiopathic. With the cancer diagnosis and treatment technology improved, the survivors are faced with the increased risk of POI. In recent years, stem cell therapy has obtained some achievements in the restoration of ovarian function at home and abroad. It has brought hope for the recovery of the endocrine function and fertility of POI patients. These stem cells include bone mesenchymal stem cells, umbilical cord mesenchymal stem cells, adipose mesenchymal stem cells, human amniotic epithelial cells (hAECs) and human amniotic mesenchymal stem cells (hAMSCs) and so on. Stem cells may provide microenvironment and inhibit follicle apoptosis by differentiating into granular cell cells or paracrine to restore damaged ovaries. This article mainly reviews research progresses about human amniotic membrane of POI.

[1]
Sadeghi MR. New hopes for the treatment of primary ovarian insufficiency/premature ovarian failure [J]. J Reprod Infertil, 2013, 14(1): 1-2.
[2]
Fu X, He Y, Xie C, et al. Bone marrow mesenchymal stem cell transplantation improves ovarian function and structure in rats with chemotherapy-induced ovarian damage [J]. Cytotherapy, 2008, 10(4): 353-363.
[3]
Takehara Y, Yabuuchi A, Ezoe K, et al. The restorative effects of adipose-derived mesenchymal stem cells on damaged ovarian function [J]. Lab Invest, 2013, 93(2): 181-193.
[4]
Griaznova IM, Molomina GG, Balios LV. Treatment of severe forms of amenorrhea and of the hypomenstrual and postcastration syndromes by transplantation of ovarian tissue in the amniotic membrane [J]. Akush Ginekol (Mosk), 1977, 2: 30-33.
[5]
Sripriya R, Kumar R. Denudation of human amniotic membrane by a novel process and its characterisations for biomedical applications [J]. Prog Biomater,2016, 5(3-4): 161-172.
[6]
Kmiecik G, Niklińska W, Kuć P, et al. Fetal membranes as a source of stem cells [J]. Adv Med Sci, 2013, 58(2): 185-195.
[7]
Takahashi N, Enosawa S, Mitani T, et al. Transplantation of amniotic epithelial cells into fetal rat liver by in utero manipulation [J]. Cell Transplant, 2002, 11(5): 443-449.
[8]
Okawa H, Okuda O, Arai H, et al. Amniotic epithelial cells transform into neuron-like cells in the ischemic brain [J]. Neuroreport, 2001, 12(18): 4003-4007.
[9]
Jiawen S, Jianjun Z, Jiewen D, et al. Osteogenic differentiation of human amniotic epithelial cells and its application in alveolar defect restoration [J]. Stem Cells Transl Med, 2014, 3(12): 1504-1513.
[10]
Lindenmair A, Nürnberger S, Stadler G, et al. Intact human amniotic membrane differentiated towards the chondrogenic lineage [J]. Cell Tissue Bank, 2014, 15(2): 213-225.
[11]
Miki T, Lehmann T, Cai H, et al. Stem cell characteristics of amniotic epithelial cells [J]. Stem Cells, 2005, 23(10): 1549-1559.
[12]
Syva SH, Ampon K, Lasimbang H, et al. Microenvironmental factors involved in human amnion mesenchymal stem cells fate decisions [J]. J Tissue Eng Regen Med, 2017, 11(2): 311-320.
[13]
Wang F, Wang L, Yao X, et al. Human amniotic epithelial cells can differentiate into granulosa cells and restore folliculogenesis in a mouse model of chemotherapy-induced premature ovarian failure [J]. Stem Cell Res Ther, 2013, 4(5): 124.
[14]
Evron A, Goldman S, Shalev E. Human amniotic epithelial cells differentiate into cells expressing germ cell specific markers when cultured in medium containing serum substitute supplement [J]. Reprod Biol Endocrinol, 2012, 10: 108.
[15]
王慧,王飞,白莉平,等. 人羊膜上皮细胞向卵泡样结构转分化的实验研究 [J]. 四川大学学报(医学版),2017, 48(4): 531-536.
[16]
Zhang Q, Xu M, Yao X, et al. Human amniotic epithelial cells inhibit granulosa cell apoptosis induced by chemotherapy and restore the fertility [J]. Stem Cell Res Ther, 2015, 6: 152.
[17]
Li J, Mao Q, He J, et al. Human umbilical cord mesenchymal stem cells improve the reserve function of perimenopausal ovary via a paracrine mechanism[J]. Stem Cell Res Ther, 2017, 8(1):55.
[18]
Ranganath SH, Levy O, Inamdar MS, et al. Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease [J]. Cell Stem Cell, 2012, 10(3): 244-258.
[19]
Baraniak PR, McDevitt TC. Stem cell paracrine actions and tissue regeneration [J]. Regen Med, 2010, 5(1): 121-143.
[20]
Zhang Q, Bu S, Sun J, et al. Paracrine effects of human amniotic epithelial cells protect against chemotherapy-induced ovarian damage [J]. Stem Cell Res Ther, 2017, 8(1): 270.
[21]
Pan Y, Zhang L, Zhang X, et al. Biological and biomechanical analysis of two types of mesenchymal stem cells for intervention in chemotherapy-induced ovarian dysfunction [J]. Arch Gynecol Obstet, 2017, 295(1): 247-252.
[22]
Lima AN, Faria AC, Lopes AJ, et al. Forced oscillations and respiratory system modeling in adults with cystic fibrosis [J]. Biomed Eng Online, 2015, 14: 11.
[23]
Ding C, Li H, Wang Y, et al. Different therapeutic effects of cells derived from human amniotic membrane on premature ovarian aging depend on distinct cellular biological characteristics [J]. Stem Cell Res Ther, 2017, 8(1): 173.
[24]
Shikanov A, Zhang Z, Xu M, et al. Fibrin encapsulation and vascular endothelial growth factor delivery promotes ovarian graft survival in mice [J]. Tissue Eng Part A, 2011, 17(23-24): 3095-3104.
[25]
Su J, Ding L, Cheng J, et al. Transplantation of adipose-derived stem cells combined with collagen scaffolds restores ovarian function in a rat model of premature ovarian insufficiency [J]. Hum Reprod, 2016, 31(5): 1075-1086.
[26]
Sugita S, Iwasaki Y, Makabe K, et al. Lack of T cell response to iPSC-derived retinal pigment epithelial cells from HLA homozygous donors [J]. Stem Cell Reports, 2016, 7(4): 619-634.
[27]
Hornick JE, Duncan FE, Shea LD, et al. Multiple follicle culture supports primary follicle growth through paracrine-acting signals [J]. Reproduction, 2013, 145(1): 19-32.
[28]
Green DM, Sklar CA, Boice JD Jr, et al. Ovarian failure and reproductive outcomes after childhood cancer treatment: results from the Childhood Cancer Survivor Study [J]. J Clin Oncol, 2009, 27(14): 2374-2381.
[29]
Wang TR, Yan LY, Yan J, et al. Basic fibroblast growth factor promotes the development of human ovarian early follicles during growth in vitro [J]. Hum Reprod, 2014, 29(3): 568-576.
[30]
Motamed M, Sadr Z, Valojerdi MR, et al. Tissue engineered human amniotic membrane application in mouse ovarian follicular culture [J]. Ann Biomed Eng, 2017, 45(7): 1664-1675.
[31]
Shea LD, Woodruff TK, Shikanov A. Bioengineering the ovarian follicle microenvironment [J]. Annu Rev Biomed Eng, 2014, 16: 29-52.
[32]
Smitz J, Dolmans MM, Donnez J, et al. Current achievements and future research directions in ovarian tissue culture, in vitro follicle development and transplantation: implications for fertility preservation [J]. Hum Reprod Update, 2010, 16(4): 395-414.
[33]
Niknejad H, Khayat-Khoei M, Peirovi H, et al. Human amniotic epithelial cells induce apoptosis of cancer cells: a new anti-tumor therapeutic strategy [J]. Cytotherapy, 2014, 16(1): 33-40.
[34]
Trumler AA, Boisvert C, Roa AM, et al. Restrictive strabismus following pterygium excision surgery combined with amniotic membrane transplantation: a retrospective case review[J]. J Aapos, 2010, 14(1):e29.
[35]
White YA, Woods DC, Takai Y, et al. Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women [J]. Nat Med, 2012, 18(3): 413-421.
[36]
Ye H, Zheng T, Li W, et al. Ovarian stem cell nests in reproduction and ovarian aging [J]. Cell Physiol Biochem, 2017, 43(5): 1917-1925.
[37]
Massasa E, Costa XS, Taylor HS. Failure of the stem cell niche rather than loss of oocyte stem cells in the aging ovary [J]. Aging (Albany NY), 2010, 2(1): 1-2.
[38]
Sun L, Akiyama K, Zhang H, et al. Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans[J]. Stem Cells, 2010, 27(6):1421-1432.
[1] 卫杨文祥, 黄浩然, 刘予豪, 陈镇秋, 王海彬, 周驰. 股骨头坏死细胞治疗的前景和挑战[J]. 中华关节外科杂志(电子版), 2023, 17(05): 694-700.
[2] 马敏榕, 李聪, 周勤. 宫颈癌治疗研究现状[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 497-504.
[3] 林昌盛, 战军, 肖雪. 上皮性卵巢癌患者诊疗中基因检测及分子靶向药物治疗[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 505-510.
[4] 顾娟, 孙擎擎, 胡方方, 曹义娟, 祁玉娟. 子宫内膜容受性检测改善胚胎反复种植失败患者妊娠结局的临床应用[J]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 582-587.
[5] 韩李念, 王君. 放射性皮肤损伤治疗的研究进展[J]. 中华损伤与修复杂志(电子版), 2023, 18(06): 533-537.
[6] 全勇, 冉新泽, 胡梦佳, 陈芳, 陈乃成, 廖伟年, 陈默, 申明强, 陈石磊, 王崧, 王军平. 低氧习服在小鼠造血干细胞急性放射损伤修复中的作用观察[J]. 中华损伤与修复杂志(电子版), 2023, 18(04): 293-298.
[7] 贾蔓箐, 卞婧, 周业平. 对小剂量胰岛素局部注射促进脂肪干细胞移植成活及改善糖尿病创面愈合临床观察[J]. 中华损伤与修复杂志(电子版), 2023, 18(04): 312-316.
[8] 贺林凤, 曹雨, 张宁, 冉新泽, 王锋超. 肠干细胞调控与肠道放射损伤修复的研究进展[J]. 中华损伤与修复杂志(电子版), 2023, 18(04): 358-363.
[9] 高雷, 李芳, 巴雅力嘎, 李全, 巴特. 干细胞源性外泌体在创伤修复中免疫作用的研究进展[J]. 中华损伤与修复杂志(电子版), 2023, 18(04): 364-367.
[10] 李晓晖, 上官昌盛, 向英, 裴芝皆, 车俊志, 谢飞. 3D腹腔镜袖状胃切除术后机体能量代谢与多囊卵巢综合征患者性激素水平关系[J]. 中华普外科手术学杂志(电子版), 2023, 17(05): 538-541.
[11] 孔欣, 宋宝全, 刘吟, 张剑, 仇惠英, 吴德沛. 异基因造血干细胞移植并发难治性呃逆一例[J]. 中华移植杂志(电子版), 2023, 17(04): 253-255.
[12] 唐英俊, 李华娟, 王赛妮, 徐旺, 刘峰, 李羲, 郝新宝, 黄华萍. 人脐带间充质干细胞治疗COPD小鼠及机制分析[J]. 中华肺部疾病杂志(电子版), 2023, 16(04): 476-480.
[13] 李晔, 何洁, 胡锦秀, 王金祥, 田川, 潘杭, 陈梦蝶, 赵晓娟, 叶丽, 张敏, 潘兴华. 高活性间充质干细胞干预猕猴卵巢衰老的研究[J]. 中华细胞与干细胞杂志(电子版), 2023, 13(04): 210-219.
[14] 陈婷婷, 江学良, 余佳丽, 柯剑林. 干细胞治疗炎症性肠病的安全性[J]. 中华消化病与影像杂志(电子版), 2023, 13(04): 193-198.
[15] 梁宇同, 丁旭, 马国慧, 黄艳红. 间充质干细胞在宫腔粘连治疗中的研究进展[J]. 中华临床医师杂志(电子版), 2023, 17(05): 596-599.
阅读次数
全文


摘要