歪嘴哭面容(ACF)是指一侧降口角肌发育不全或缺失，导致患儿啼哭时嘴角不能下拉，形成不对称面部畸形。ACF患儿多合并其他畸形，如先天性心脏病等。若ACF合并其他畸形，则称为歪嘴哭综合征。临床医师对于ACF的诊断，应注意与产伤或发育异常造成的中枢性面神经麻痹进行区别。对于ACF患儿，临床应严密警惕其合并脏器畸形可能，对患儿进行全面体格检查，及时发现合并的脏器畸形，并予以早期治疗，可降低脏器畸形造成的危害。该病的发生与22q11.2染色体缺失有关。我国对ACF文献报道较少，临床对该病的认识尚不够深入。因此，笔者拟就ACF的发病情况、病因、临床表现、诊断及治疗的临床研究现状进行阐述，并结合笔者临床经验，提出相应建议，旨在为临床提高对该病诊治水平。

Asymmetric crying facies (ACF) is congenital hypoplasia of the depressor anguli oris muscle characterized by asymmetry of lower lip depression during crying. ACF is often associated with other malformations such as congenital heart diseases. If ACF is complicated with other malformations, then it is called asymmetric crying syndrome. Clinicians should pay attention to the difference of central facial palsy caused by birth injury or abnormal development in the diagnosis of ACF. For children with ACF, it is necessary to be vigilant about the possibility of complicated organ malformations. It is advised to carry out systemic physical examinations to discover the complicated organ malformations in time and give early medical treatment to reduce the harm caused by organ malformations. Previous studies have reported that ACF is related to 22q11.2 chromosome deletion. There is less report on ACF in China, and the understanding of this disease is still not enough. Therefore, the authors intend to expound the clinical research status of the incidence, etiology, clinical manifestation, diagnosis and treatment of ACF, and put forward corresponding suggestions according to the authors′ clinical experience, aiming at improving the diagnosis and treatment of this disease.