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中华妇幼临床医学杂志(电子版) ›› 2016, Vol. 12 ›› Issue (02) : 237 -240. doi: 10.3877/cma.j.issn.1673-5250.2016.02.020

所属专题: 文献

综述

不明原因复发性流产发病机制研究进展
马韵1   
  1. 1. 030001 太原,山西医科大学第一医院计划生育研究室
  • 收稿日期:2015-12-13 修回日期:2016-02-01 出版日期:2016-04-01

Research progress of pathogenesis of unexplained recurrent spontaneous abortion

Yun Ma1   

  1. 1. Department of Family Planning, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
  • Received:2015-12-13 Revised:2016-02-01 Published:2016-04-01
  • About author:
    Corresponding author: Zheng Meiling, Email:
引用本文:

马韵. 不明原因复发性流产发病机制研究进展[J/OL]. 中华妇幼临床医学杂志(电子版), 2016, 12(02): 237-240.

Yun Ma. Research progress of pathogenesis of unexplained recurrent spontaneous abortion[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2016, 12(02): 237-240.

复发性自然流产(RSA)病因复杂,是导致继发不孕的重要因素之一,在育龄期女性中RSA发生率为1%~5%。目前已知的导致RSA发病的危险因素包括夫妇双方染色体异常因素、子宫解剖结构异常、女性孕期内分泌功能异常、合并自身免疫性疾病,以及存在血栓前状态、感染及环境异常因素等。目前,仍有50% RSA患者未能发现明确的致病因素,这部分RSA被称为不明原因复发性流产(URSA)。近年研究发现,导致URSA发生的危险因素包括免疫系统功能异常因素、胎盘血供异常、叶酸代谢酶基因突变及精子异常因素等。笔者拟就临床对URSA发病机制的研究进展进行综述。

The causes of recurrent spontaneous abortion (RSA) are extremely complicated, and RSA has become the main cause of secondary infertility. The incidence of RSA in females during child-bearing period is 1%-5%. So far, possible risk factors of RSA include genetic abnormalities, anatomical deformities of uterus, endocrine dysfunctions during pregnancy, complicated with autoimmune diseases, pre-thrombosis, infection factors as well as environmental abnormality and so on. But the causes of more than 50% RSA are still unknown, and those RSA are called unexplained recurrent spontaneous abortion (URSA). Recent researches showed that risk factors for URSA were gradually realized, such as immune system dysfunction, abnormal placental blood supply, folate metabolism enzyme gene mutation and sperm factors and so on. This review will summarize the research progress of pathogenesis of URSA.

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