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中华妇幼临床医学杂志(电子版) ›› 2016, Vol. 12 ›› Issue (01) : 96 -99. doi: 10.3877/cma.j.issn.1673-5250.2016.01.018

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综述

小分子干扰RNA干扰相关基因表达对卵巢癌化疗敏感性影响的研究进展
李冉红1, 陈晨1, 刘辉1,*,*()   
  1. 1. 610041 成都,四川大学华西第二医院妇产科
  • 收稿日期:2015-08-09 修回日期:2015-12-09 出版日期:2016-02-01
  • 通信作者: 刘辉

Research progress of related gene expression interfered by small interfering RNA in drug-sensibility of ovarian cancer chemotherapy

Ranhong Li1, Chen Chen1, Hui Liu1()   

  1. 1. Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2015-08-09 Revised:2015-12-09 Published:2016-02-01
  • Corresponding author: Hui Liu
  • About author:
    Corresponding author: Liu Hui, Email:
引用本文:

李冉红, 陈晨, 刘辉. 小分子干扰RNA干扰相关基因表达对卵巢癌化疗敏感性影响的研究进展[J/OL]. 中华妇幼临床医学杂志(电子版), 2016, 12(01): 96-99.

Ranhong Li, Chen Chen, Hui Liu. Research progress of related gene expression interfered by small interfering RNA in drug-sensibility of ovarian cancer chemotherapy[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2016, 12(01): 96-99.

卵巢癌是女性生殖系统常见3大恶性肿瘤之一,导致的患者病死率居妇科恶性肿瘤首位,严重威胁女性的健康与生命。目前卵巢癌以手术和化疗为主要治疗方法,而肿瘤对化疗药物产生耐药,是导致治疗失败的重要原因之一。因此,研究卵巢癌细胞的耐药性逆转作用,对提高临床治疗效果意义重大。而小分子干扰RNA(siRNA)是由双链RNA在多种酶共同作用下产生的小片段双链RNA,可与同源的靶mRNA互补结合,特异性降解靶mRNA。因此,通过设计针对性的siRNA干扰与肿瘤发生、发展相关的基因,如Id1、STAT3、MDR1、BAF57及CXCR4等表达,可提高卵巢癌细胞对化疗药物的敏感性,为卵巢癌细胞耐药性逆转研究提供初步理论依据。

Ovarian cancer is one of the three most common and lethal malignance in reproductive system of women, the mortality of which has become the highest in gynecological cancer.Ovarian cancer has been severely threatened the health and life of females.At present, surgery and chemotherapeutic have become the main therapy for ovarian cancer, however, the drug-resistance of tumors has been the important reason for the treatment failure. So study on the reversion of drug- resistance in ovarian cancer cell is significant for improving the effect of clinical treatment of ovarian cancer.Small interfering RNA(siRNA) is small fragments of double-stranded RNA produced jointly by a variety of enzymes, which can combine with homologous target mRNA complementarily and degraded target mRNA specifically.So, designing the specific siRNA to interference with expression of genes which related with the occurrence and development of tumors, such as Id1, STAT3, MDR1, BAF57 and CXCR4, etc., can improve the sensitivity of ovarian cancer cells to chemotherapy drugs, which provides the preliminary theoretical basis for research of ovarian cancer cells resistance reversal.

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