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中华妇幼临床医学杂志(电子版) ›› 2015, Vol. 11 ›› Issue (01) : 86 -89. doi: 10.3877/cma.j.issn.1673-5250.2015.01.020

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综述

多囊卵巢综合征蛋白质组学的研究现状
李荔1, 张江宇2, 王晓琴2, 罗辉2, 刘花园2, 张婧2,*,*()   
  1. 1. 00853 澳门科技大学中药质量研究国家重点实验室;510010 广东省妇幼保健院暨广州医科大学附属广东省妇儿医院
    2. 00853 澳门科技大学中药质量研究国家重点实验室
  • 收稿日期:2014-11-05 修回日期:2014-12-10 出版日期:2015-02-01
  • 通信作者: 张婧

Research of polycystic ovary syndrome in proteomics

Li Li1, Jiangyu Zhang2, Xiaoqin Wang2, Hui Luo2, Huayuan Liu2, Jing Zhang2()   

  1. 1. Laboratory of Chinese Medicine Quality Research, Macau University of Science and Technology, Macau 00853, China; Department of Obstetrics and Gynecology, Guangdong Maternity and Child Health Hospital, Guangzhou Medical University, Guangzhou 510010, Guangdong Province, China
    2. Laboratory of Chinese Medicine Quality Research, Macau University of Science and Technology, Macau 00853, China
  • Received:2014-11-05 Revised:2014-12-10 Published:2015-02-01
  • Corresponding author: Jing Zhang
  • About author:
    Corresponding author: Zhang Jing, Email:
引用本文:

李荔, 张江宇, 王晓琴, 罗辉, 刘花园, 张婧. 多囊卵巢综合征蛋白质组学的研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2015, 11(01): 86-89.

Li Li, Jiangyu Zhang, Xiaoqin Wang, Hui Luo, Huayuan Liu, Jing Zhang. Research of polycystic ovary syndrome in proteomics[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2015, 11(01): 86-89.

多囊卵巢综合征(PCOS)是一种复杂、多因性的内分泌紊乱和代谢性疾病。PCOS患者具有排卵功能障碍、高雄激素血症或高雄激素表现、多囊卵巢形态等特点,主要临床症状为超重或肥胖,其中50%~70%的PCOS患者合并胰岛素抵抗和代偿性高胰岛素血症。目前,蛋白质组学研究被越来越多地应用于PCOS的诊断和治疗。笔者拟就目前PCOS蛋白质组学研究的常用技术进行概括,从发病机制、诊断标志物及远期并发症的3个方面对PCOS蛋白质组学的研究现状进行总结,并对PCOS的研究前景进行展望。

Polycystic ovary syndrome (PCOS) is a kind of disease with complex endocrine and metabolic disorder, which is characterized by ovulatory dysfunction, hyperandrogenism, hyperandrogenism performance or polycystic ovarian morphology.Among them, 50%-70% of PCOS patients are accompanied by insulin resistance and compensatory hyperinsulinemia disease.Currently, proteomics research is increasingly used in the diagnosis and treatment of PCOS. This article outlines the common usage of proteomics techniques, summarizes the current research of PCOS in proteomics from aspects of the pathogenesis, diagnostic markers and long-term complications and discusses the outlook of PCOS proteomics research.

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