探讨产后溶血性尿毒症综合征(PHUS)的临床特征，为该病的早期诊断、及时治疗和改善预后提供依据。

选择2008年1月至2012年12月南京医科大学附属苏州医院收治的6例PHUS患者的病历资料为研究对象，孕龄≥33孕周。采用回顾性分析法分析其临床症状、体征、溶血性尿毒症相关指标、超声检查及外周血涂片等检查结果(本研究遵循的程序符合南京医科大学附属苏州医院人体试验委员会制定的伦理学标准，得到该委员会批准)。

本研究6例患者均为妊娠合并重度先兆子痫，经解痉、降压治疗并促胎肺成熟后，行剖宫产术分娩，并获活产新生儿者。6例患者均于剖宫产术后1~2 d无诱因出现进行性少尿及无尿，合并溶血性贫血、血小板减少和肾功能急剧下降等，经过连续肾脏替代治疗(CRRT联合血浆置换为主的综合治疗后病情稳定，好转出院。对其随访1年，其中3例(50.0%)患者失访，1例(16.7%)患者发展为慢性肾功能不全。

先兆子痫是PHUS的重要诱因之一，应加强先兆子痫孕妇产后的肾功能监测，早期诊断PHUS，及时进行专科治疗，这对降低产妇死亡率和保障母亲健康具有重要意义。

To investigate the clinic features of postpartum hemolytic uremic syndrome (PHUS) for early diagnosis, prompt therapy and better prognosis.

A retrospective study was conducted on clinical data of 6 PHUS patients with gestational age over 33 weeks in Suzhou Hospital Affiliated to Nanjing Medical University from January 2008 to December 2012. Clinical symptoms and signs, hemolytic uremic related indexes, ultrasonograph and peripheral blood smear of them were analyzed. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Suzhou Hospital Affiliated to Nanjing Medical University.

All 6 patients had pregnancy combined with severe preeclampsia. After antispasmodic, antihypertensive treatment and promot fetal lung mature, they gave birth by cesarean section, and no neonatal death. The main symptoms were gradually oliguria and anuria without remote cause, hemolytic anemia, thrombocytopenia and sharp decline of renal function after 1-2 days of cesarean section. Through comprehensive treatment based on continuous renal replacement therapy (CRRT) and plasma exchange, the patient's conditions were stable and improved, and all patients were discharged from hospital. After 1 year follow up, 3 cases(50.0%) were lost to follow up, l case (16.7%) with chronic renal insufficiency.

Preeclampsia is one of the important remote causes of PHUS. It's necessary to strengthen renal function monitoring of pregnant women with preeclampsia after childbirth, in order to make early diagnosis and give specialized treatment in time, which are significant measures to reduce maternal mortality and ensure mother's healthy.