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中华妇幼临床医学杂志(电子版) ›› 2014, Vol. 10 ›› Issue (02) : 249 -252. doi: 10.3877/cma.j.issn.1673-5250.2014.02.028

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综述

Notch信号通路在哮喘及T淋巴细胞调节中的作用研究进展
强巴措珍1, 刘瀚旻2,*,*()   
  1. 1. 610041 成都,四川大学华西第二医院儿科;拉萨市人民医院儿科
    2. 610041 成都,四川大学华西第二医院儿科
  • 收稿日期:2014-01-10 修回日期:2014-03-07 出版日期:2014-04-01
  • 通信作者: 刘瀚旻

Research Progress of the Roles of Notch Signaling Pathway in Asthma and T Lymphocytes Regulation

Bacuozhen Qiang1, Hanmin Liu2()   

  1. 1. Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2014-01-10 Revised:2014-03-07 Published:2014-04-01
  • Corresponding author: Hanmin Liu
  • About author:
    (Corresponding author: Liu Hanmin, Email: )
引用本文:

强巴措珍, 刘瀚旻. Notch信号通路在哮喘及T淋巴细胞调节中的作用研究进展[J/OL]. 中华妇幼临床医学杂志(电子版), 2014, 10(02): 249-252.

Bacuozhen Qiang, Hanmin Liu. Research Progress of the Roles of Notch Signaling Pathway in Asthma and T Lymphocytes Regulation[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2014, 10(02): 249-252.

Notch信号通路参与多种组织细胞的分化、成熟过程,尤其在T淋巴细胞的分化过程中起了决定性作用。近年来,大量研究表明,Notch信号通路参与支气管哮喘(BA)发病的整个病理过程,包括气道炎症、气道高反应、气道重塑及气道血管重塑。笔者拟就Notch信号通路在BA和T淋巴细胞调节中的作用,进行综述如下。

Notch signaling pathway involves in cell differentiation process in a lot of tissues, especially playing an important role in T lymphocytes differentiation process. Recently, many reports have demonstrated that the Notch signaling pathway involves in the whole pathogenesis of bronchial asthma(BA) pathological process, including airway inflammation, airway hyperresponsiveness, airway remodeling and vascular remodeling of the airway. This paper summarizes the roles of Notch signaling pathway in BA and T lymphocyte regulation.

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