不同方法治疗外阴上皮内非瘤样病变疗效比较

doi:10.3877/cma.j.issn.1673-5250.2013.06.024

中华妇幼临床医学杂志(电子版) ›› 2013, Vol. 09 ›› Issue (06) : 818 -820. doi: 10.3877/cma.j.issn.1673-5250.2013.06.024

所属专题：文献；

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不同方法治疗外阴上皮内非瘤样病变疗效比较

杜则玲¹^,^*^,^*(

)

^1. 211800　江苏南京，南京市浦口区中心医院妇产科

收稿日期:2013-06-09 修回日期:2013-09-23 出版日期:2013-12-01
通信作者: 杜则玲

Two Methods for the Treatment of Nonneoplastic Epithelial Disorders of Skin and Mucosa of Vulva Curative Effect Comparison

Ze-ling DU¹()

^1. Department of Obstetrics and Gynecology , Nanjing Pukou District Center Hospital, Nanjing 211800, Jiangsu Province, China

Received:2013-06-09 Revised:2013-09-23 Published:2013-12-01
Corresponding author: Ze-ling DU
About author:
(Corresponding author : DU Ze-ling,Email : duzeling@163. com)

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目的

探讨超声治疗外阴上皮内非瘤样病变(NEDV)的疗效。

方法

选择2010年1月至2012年1月南京市浦口区中心医院妇科收治的73例NEDV患者为研究对象。将其按照接受治疗顺序号随机分为：超声治疗组(n = 36)和药物治疗组(n=37)。两组病例年龄和病程长短比较，差异无统计学意义(P>0.05)。采用统计学方法分析两组患者的临床症状、体征和组织学变化（本研究遵循的程序符合南京市浦口区中心医院人体试验委员会制定的伦理学标准，得到该委员会批准，征得受试对象知情同意，并与之签署临床研究知情同意书）。

结果

超声治疗组患者的外阴瘙痒症状基本消失，患处上皮不同程度恢复正常，治愈及显效率共为91.7%。同一组中不同病理类型NEDV患者的疗效比较，差异无统计学意义（P> 0.05）。两组显效率及复发率比较，差异均有统计学意义(P<0. 05)。

结论

超声治疗NEDV疗效明显。

关键词: 超声治疗, 外阴上皮内非瘤样病变, 药物治疗, 女性

Objective

To investigate the effect of ultrasonic therapy for nonneoplastic epithelial disorders of skin and mucosa of vulva (NEDV).

Methods

From January 2010 to January 2011,a total of 73 cases of NEDV patients were treated and randomly (according to numbers of treatment) divided into two groups:ultrasonic therapy group(n= 36), drug therapy group(n = 37). There were no significant difference in general clinical data between two groups (P>0. 05). Observe the clinical symptoms, signs and histological changes between two groups. The study protocol was approved by the Ethical Review Board of Investigation in Human Beings of Nanjing Pukou District Center Hospital. Informed consent was obtained from each participating patient.

Results

The ultrasonic treatment group of 36 patients with vulva pruritus symptom disappeared basically, and epithelium lesions in different level back to normal, the cure and significant efficiency rate was 91. 7 %. Comparison of curative effect between different pathological type in the same group,the data has no significant difference (P>0. 05). There had significant difference between two groups in cure rate and significant efficiency rate (P<0. 05).

Conclusions

Curative effect of ultrasonic therapy for NEDV is obvious.

Key words: ultrasonic therapy, nonneoplastic epithelial disorders of skin and mucosa of vulva, drug therapy, women

表1 超声治疗后疗效分析[n(％)]

Table 1 Curative effects after ultrasonic treatment [n(%)]

病理类型	n	治愈率	显效率	好转率	无效率	复发率
鳞状上皮增生型	20	12(33.3)	6(16.7)	2(5.6)	0(0. 0)	1(2.8)
硬化苔癣型	16	11(30.6)	4(11.1)	1(2.8)	0(0. 0)	0(0.0)
合计	36	23(63.9)	10(27.8)	3(8.3)	0(0. 0)	1(2.8)
χ²	0. 467	0. 295	0. 111	0. 164	?	0. 823
P	0. 882	0. 731	1. 000	1. 000	?	1. 000

表1 超声治疗后疗效分析[n(％)]

Table 1 Curative effects after ultrasonic treatment [n(%)]

病理类型	n	治愈率	显效率	好转率	无效率	复发率
鳞状上皮增生型	20	12(33.3)	6(16.7)	2(5.6)	0(0. 0)	1(2.8)
硬化苔癣型	16	11(30.6)	4(11.1)	1(2.8)	0(0. 0)	0(0.0)
合计	36	23(63.9)	10(27.8)	3(8.3)	0(0. 0)	1(2.8)
χ²	0. 467	0. 295	0. 111	0. 164	?	0. 823
P	0. 882	0. 731	1. 000	1. 000	?	1. 000

表2 药物治疗后疗效分析[n(％)]

Table 2 Curative effects after drug therapy[n(%)]

病理类型	n	治愈率	显效率	好转率	无效率	复发率
鳞状上皮增生型	18	6(16.2)	6(16.2)	3 (8. 1)	3(8.1)	12(32. 4)
硬化苔癣型	19	5(13.5)	7(18.9)	4(10.8)	3(8.1)	13(35. 1)
合计	37	11(29.7)	13(35.1)	7(18.9)	6(16.2)	25(67. 6)
χ²	0. 508	0. 218	0. 050	0. 116	0. 005	0. 130
P	1. 000	0. 728	1. 000	1. 000	1. 000	1. 000

表2 药物治疗后疗效分析[n(％)]

Table 2 Curative effects after drug therapy[n(%)]

病理类型	n	治愈率	显效率	好转率	无效率	复发率
鳞状上皮增生型	18	6(16.2)	6(16.2)	3 (8. 1)	3(8.1)	12(32. 4)
硬化苔癣型	19	5(13.5)	7(18.9)	4(10.8)	3(8.1)	13(35. 1)
合计	37	11(29.7)	13(35.1)	7(18.9)	6(16.2)	25(67. 6)
χ²	0. 508	0. 218	0. 050	0. 116	0. 005	0. 130
P	1. 000	0. 728	1. 000	1. 000	1. 000	1. 000

表3 2组病人疗效比较[n(%)]

Table 3 Comparison of curative effects between two groups[n(%)]

组别	n	治愈及显效率	复发率
超声治疗组	36	33(91. 7)	1 (2.8)
药物治疗组	37	24(64. 9)	25(67.6)
χ²	?	7. 659	33. 402
P	?	0. 010	0. 000

表3 2组病人疗效比较[n(%)]

Table 3 Comparison of curative effects between two groups[n(%)]

组别	n	治愈及显效率	复发率
超声治疗组	36	33(91. 7)	1 (2.8)
药物治疗组	37	24(64. 9)	25(67.6)
χ²	?	7. 659	33. 402
P	?	0. 010	0. 000

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