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中华妇幼临床医学杂志(电子版) ›› 2013, Vol. 09 ›› Issue (06) : 801 -804. doi: 10.3877/cma.j.issn.1673-5250.2013.06.019

所属专题: 文献

论著

匹多莫德联合布地奈德气雾剂治疗儿童支气管哮喘的疗效及安全性研究
谢莉1, 刘蓉1, 李艳1,*,*(), 佘静1   
  1. 1. 621000 绵阳市中心医院儿科
  • 收稿日期:2013-06-12 修回日期:2013-11-05 出版日期:2013-12-01
  • 通信作者: 李艳

Efficacy and Safety of Pidotimod Combined With Budesonide Aerosol in the Treatment of Bronchial Asthma in Children

Li XIE1, Rong LIU1, Yan LI,1, Jing YU1   

  1. 1. Department of Pediatrics , Central Hospital of Mianyang, Mianyang 621000, Sichuan Province, China
  • Received:2013-06-12 Revised:2013-11-05 Published:2013-12-01
  • Corresponding author: Yan LI
  • About author:
    (Corresponding author : LI Yan , Email : )
引用本文:

谢莉, 刘蓉, 李艳, 佘静. 匹多莫德联合布地奈德气雾剂治疗儿童支气管哮喘的疗效及安全性研究[J/OL]. 中华妇幼临床医学杂志(电子版), 2013, 09(06): 801-804.

Li XIE, Rong LIU, Yan LI, Jing YU. Efficacy and Safety of Pidotimod Combined With Budesonide Aerosol in the Treatment of Bronchial Asthma in Children[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2013, 09(06): 801-804.

目的

探讨匹多莫德联合布地奈德气雾剂治疗儿童支气管哮喘的疗效及安全性。

方法

选取2011年6月至2012年9月于绵阳市中心医院儿科门诊治疗的200例支气管哮喘患儿为研究对象,根据治疗方法不同,将其分为观察组(n= 100,匹多莫德+布地奈德气雾剂)和对照组(n= 100,仅用布地奈德气雾剂)。两组患儿的性别、平均年龄、病程及病情严重程度分级等基础资料比较,差异无统计学意义(P> 0.05)(本研究遵循的程序符合绵阳市中心医院人体试验委员会制定的伦理学标准,得到该委员会批准,分组征得受试患儿监护人的知情同意,并与之签署临床研究知情同意书)。比较两组患儿的疗效、哮喘发作次数、发作持续时间等。

结果

观察组的总有效率明显高于对照组(95.00% vs. 74.00%,P<0.01)。观察组的哮喘发作持续时间[(4.00±1. 32) d vs. (6. 78±1.58) d,P<0. 05]以及发作程度(P<0. 01)均明显短于对照组。

结论

匹多莫德联合布地奈德气雾剂治疗儿童支气管哮喘疗效更佳。

Objective

To investigate the efficacy and safety of pidotimod combined with budesonide aerosol in the treatment of bronchial asthma in children.

Methods

Selected 200 cases children with asthma treated in hospital outpatient from June 2011 to September 2012 as research subjects. They were randomly divided into observation group (n = 100,budesonide aerosol + pidotimod) and control group (n = 100, budesonide aerosol) according to the different therapeutic methods. Comparison of the two groups of gender, average age,duration and severity grading and other basic information on aspects of children, the differences were not statistically significant (P>0. 05). In this study, the procedure followed in line with ethical standards established by Institutional Review Board of the Central Hospital of Mianyang, approved by the Commission, grouping the consent of the guardian of the children tested, and with the signing of informed consent in clinical research. The following information were compared between two groups,the number of asthma attacks,attack duration and extent of attack.

Results

The efficient of observation group was significantly higher than that in control group(95. 00% vs. 74. 00%,P<0. 01). The number of asthma attacks, attack duration [(4. 00±1. 32) d vs. (6. 78 ± 1. 58) d,P<0. 05] and extent of attack(P<0. 01) were significantly shorter than those of control group.

Conclusions

Pidotimod combined with budesonide aerosol in the treatment of bronchial asthma in children is better than budesonide only.

表1 支气管哮喘患儿病情严重程度的分级
Table 1 Classification of asthma severity
表2 两组患儿一般资料比较(±s)
Table 2 Comparison of general information between two groups ( ± s)
表3 哮喘急性发作期病情严重程度的分级
Table 3 Acute episodes of asthma severity classification
表4 两组疗效比较[n(%)]
Table 4 Comparison of efficacy between two groups[n(%)]
表5 两组患儿哮喘发作程度及持续时间的比较(±s)
Table 5 Comparison of degree and duration of acute attack of asthma between two groups(±s)
表6 两组患儿不良反应比较[n(%)]
Table 6 Comparison of adverse reactions between two groups[n(%)]
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