纳洛酮治疗小儿重症肺炎合并心力衰竭的疗效

doi:10.3877/cma.j.issn.1673-5250.2013.02.022

中华妇幼临床医学杂志(电子版) ›› 2013, Vol. 09 ›› Issue (02) : 219 -221. doi: 10.3877/cma.j.issn.1673-5250.2013.02.022

所属专题：文献；

论著

纳洛酮治疗小儿重症肺炎合并心力衰竭的疗效

王琪¹^,^*^,^*(

)

^1. 476100　河南商丘，商丘市第一人民医院

收稿日期:2013-01-17 修回日期:2013-02-27 出版日期:2013-04-01
通信作者: 王琪

Clinical Effect of Naloxone Treatment to Severe Pneumonia Complicated With Heart Failure in Children

Qi WANG¹()

^1. Department of PICU, First People's Hospital of Shangqiu, Shangqiu 476100, Henan Province, China

Received:2013-01-17 Revised:2013-02-27 Published:2013-04-01
Corresponding author: Qi WANG
About author:
(Corresponding author: WANG Qi, Email: wuyuwuqiu88@126.com)

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目的

探讨纳洛酮在小儿重症肺炎合并心力衰竭中的临床治疗作用。

方法

选择2010年10月至2011年10月于本院就诊的65例重症肺炎合并心力衰竭患儿为研究对象，按照随机数字表法将其分为观察组(n＝32)和对照组(n＝33)。两组均接受基础治疗，观察组同时加用纳洛酮治疗。观察两组患儿症状、阳性体征缓解时间和治疗有效率(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准，得到该委员会批准，分组征得受试对象监护人的知情同意，并与之签署临床研究知情同意书)。两组患儿年龄、性别、体温、临床症状、辅助检查结果等方面比较，差异无统计学意义(P>0.05)。

结果

两组患儿症状、阳性体征缓解时间比较，差异有统计学意义(P<0.05)。两组患儿治疗5 d时治疗有效率比较，差异有统计学意义(P<0.05)。

结论

纳洛酮可有效缩短小儿重症肺炎合并心力衰竭的病程，临床治疗效果显著。

关键词: 儿童, 重症肺炎, 心力衰竭, 纳洛酮

Objective

To explore the clinical effect of naloxone to severe pneumonia complicated with heart failure in children.

Methods

From October 2010 to October 2011, 65 children with severe pneumonia complicated with heart failure were included in the study, and randomly divided into observation group(n=32) and control group(n=33). Basic treatment were given in both groups, and naloxone was given in observation group for treatment too. The symptoms and positive signs recovery time and effective rate were observed. There was no significant difference between two groups in age, sex, symptoms, lab results (P>0.05). The study protocol was approved by the Ethical Review Board of Investigation in Human Being of First People's Hospital of Shangqiu.Informed consent was obtained from each parents.

Results

There had significant differences in symptoms and positive signs recovery time between two groups(P<0.05). There also had significant difference in effective rate between two groups(P<0.05).

Conclusions

Naloxone has a significant clinical effect to severe pneumonia complicated with heart failure in children, and it can effectively shorten the course of the disease.

Key words: child, severe pneumonia, heart failure, naloxone

表1 两组患儿症状和阳性体征缓解时间比较(d，±s)

Table 1 Comparison of positive signs and symptoms recovery time between two groups(d，±s)

组别	n	体温缓解时间	呼吸急促缓解时间	面色发绀缓解时间	心动过速缓解时间	肝脏肿大缓解时间
观察组	33	1.52±0.60	2.43±0.66	2.56±1.01	2.35±0.92	2.62±0.90
对照组	32	2.21±0.72	3.39±0.98	3.21±0.87	3.28±0.73	3.29±1.07
t		2.18	2.73	2.88	3.15	2.44
P		<0.05	<0.01	<0.01	<0.01	<0.05

表1 两组患儿症状和阳性体征缓解时间比较(d，±s)

Table 1 Comparison of positive signs and symptoms recovery time between two groups(d，±s)

组别	n	体温缓解时间	呼吸急促缓解时间	面色发绀缓解时间	心动过速缓解时间	肝脏肿大缓解时间
观察组	33	1.52±0.60	2.43±0.66	2.56±1.01	2.35±0.92	2.62±0.90
对照组	32	2.21±0.72	3.39±0.98	3.21±0.87	3.28±0.73	3.29±1.07
t		2.18	2.73	2.88	3.15	2.44
P		<0.05	<0.01	<0.01	<0.01	<0.05

表2 两组患儿治疗5 d时疗效比较[n(%)]

Table 2 Comparison of curative effect between two groups at the fifth day after therapy[n(%)]

组别	n	疗效			有效率
组别	n	治愈	好转	无效	有效率
观察组	33	22(66.7)	8(24.2)	3 (9.1)	30(90.9)
对照组	32	15(46.9)	9(28.1)	8(25.0)	24(75.0)
χ²					13.47
P					<0.01

表2 两组患儿治疗5 d时疗效比较[n(%)]

Table 2 Comparison of curative effect between two groups at the fifth day after therapy[n(%)]

组别	n	疗效			有效率
组别	n	治愈	好转	无效	有效率
观察组	33	22(66.7)	8(24.2)	3 (9.1)	30(90.9)
对照组	32	15(46.9)	9(28.1)	8(25.0)	24(75.0)
χ²					13.47
P					<0.01

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Clinical Effect of Naloxone Treatment to Severe Pneumonia Complicated With Heart Failure in Children

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Clinical Effect of Naloxone Treatment to Severe Pneumonia Complicated With Heart Failure in Children