切换至 "中华医学电子期刊资源库"

中华妇幼临床医学杂志(电子版) ›› 2012, Vol. 08 ›› Issue (06) : 700 -703. doi: 10.3877/cma.j.issn.1673-5250.2012.06.006

所属专题: 文献

论著

育龄妇女血清叶酸及红细胞叶酸水平检测分析
速存梅1,*,*(), 叶汉风2, 王珏1, 廖戎1, 陈涓涓2, 刘清梅1, 李丽芳1   
  1. 1. 650021 昆明, 云南省人口和计划生育科学技术研究所
    2. 云南省生育调节与少数民族优生研究重点实验室
  • 收稿日期:2012-06-05 修回日期:2012-10-18 出版日期:2012-12-01
  • 通信作者: 速存梅

Analysis of Serum Folic Acid and Red Blood Cell Folic Acid Concentrations Among 261 Childbearing-Aged Women

Cun-mei SU1(), Han-feng YE2, Jue WANG1, Rong LIAO1, Juan-juan CHEN2, Qing-mei LIU1, Li-fang LI1   

  1. 1. Yunnan Population and Family Planning Research Institute of Science and Technology, Kunming 650021, Yunnan Province, China
  • Received:2012-06-05 Revised:2012-10-18 Published:2012-12-01
  • Corresponding author: Cun-mei SU
  • About author:
    (Corresponding author: SU Cun-mei, Email: )
引用本文:

速存梅, 叶汉风, 王珏, 廖戎, 陈涓涓, 刘清梅, 李丽芳. 育龄妇女血清叶酸及红细胞叶酸水平检测分析[J/OL]. 中华妇幼临床医学杂志(电子版), 2012, 08(06): 700-703.

Cun-mei SU, Han-feng YE, Jue WANG, Rong LIAO, Juan-juan CHEN, Qing-mei LIU, Li-fang LI. Analysis of Serum Folic Acid and Red Blood Cell Folic Acid Concentrations Among 261 Childbearing-Aged Women[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2012, 08(06): 700-703.

目的

了解育龄妇女血清叶酸及红细胞叶酸水平,为昆明地区育龄妇女增补叶酸预防神经管畸形(NTDs)等出生缺陷提供参考。

方法

选取2010年1月至2011年10月于本研究所门诊就诊的261例育龄妇女为研究对象。采集其年龄、孕次等相关临床资料(本研究遵循的程序符合云南省人口和计划生育科学技术研究所人体试验委员会所制定的伦理学标准,得到该委员会批准,征得受试者知情同意,并与之签署临床研究知情同意书)。采集受试者空腹静脉血4 mL,采用电化学发光法分别测定血清叶酸及红细胞叶酸水平。以预防NTDs的叶酸推荐值为标准,进行叶酸水平分析。

结果

261例育龄妇女的血清叶酸、红细胞叶酸的平均水平分别为(9.74±3.23)ng/L和(529.79±205.44)ng/L,以试剂盒正常参考值为标准判断标准。本组受试者血清叶酸和红细胞叶酸缺乏率分别为8.43%(22/261)和5.36%(14/261)。若以预防NTDs推荐值为标准进行判断,则本组妇女血清叶酸、红细胞叶酸水平偏低率分别为67.82%(177/261)和73.95%(193/261)。

结论

昆明地区育龄妇女叶酸缺乏率不高,但仍有超过1/2以上育龄妇女的血液叶酸水平低于预防NTDs的推荐值,故对育龄妇女须加强叶酸增补方面的知识普及。

Objective

To investigate the level of serum folic acid, red blood cell (RBC) folic acid among childbearing-aged women and provide information for carrying out suping folic acid to prevent birth defects.

Methods

From January 2010 to October 2011, a total of 261 childbearing-aged women were included into this study. Their age, and related clinical data were collected and analyzed. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Yunnan Population and Family Planning Research Institute of Science and Technology. Informed consent was obtained from each participate. And 4 mL venous blood was drawn. Serum and RBC folic acid concentrations were detected by electrochemiluminescence immunoassay.

Results

The average level of serum folic acid was (9.74±3.23) ng/L and RBC folic acid was (529.79±205.44) ng/L.The prevalence of low serum folic acid and RBC folic acid concentrations were 8.43%(22/261), and 5.36%(14/261), respectively. Taking the optimal level of folic acid to prevent neural tube defects (NTDs) as the determine, the prevalence of low serum folic acid and RBC folic acid concentrations were 67.82%(177/261) and 73.95%(193/261), respectively.

Conclusions

The serum and RBC folic acid levels among more than half of childbearing-aged women in Kunming region below the recommended level for the prevention of NTDs. So the actual intake of folic acid should be strength.

表1 不同年龄段妇女血液叶酸水平比较[ng/L,n(%)]
Table 1 Comparison of folic acid levels among 261 childbearing-aged women at different ages[ng/L,n(%)]
表2 城市与农村育龄妇女叶酸水平比较[ng/L,n(%)]
Table 2 Comparison of folic acid levels among 261 childbearing-aged women from urban and rural [ng/L,n(%)]
表3 不同教育背景妇女叶酸水平比较[ng/L,n(%)]
Table 3 Comparison of folic acid level among 261 childbearing-aged women of different educational levels [ng/L,n(%)]
[1]
Wilson RD, Davies G, Desilets V, et al. The use of folic acid for the prevention of neural tube defects and other congenital anomalies[J]. J Obstet Gynaecol Can, 2003, 25(11):959.
[2]
Mosley BS, Hobbs CA, Flowers BS, et al. Folic acid and the decline in neural tube defects in Arkansas[J]. J Ark Med Soc, 2007, 103(10):247-250.
[3]
Liu XH, Qiao R. Focus on nutrition and improve health care quality in perinatal period[J/CD]. Chin J Obstet Gynecol:Electron Ed, 2010, 6(4):231-234.
[4]
Tamura T, Piccian MF. Folate and human reproduction[J]. Am J Clin Nutr, 2006, 83(5):993-1016.
[5]
Dang SN, Yan H, Xing Y, et al. Hemoglobin and serum folate levels among women of childbearing age in Shaanxi[J]. Chin J Public Health, 2009, 25(2):132-134.
[6]
Ganji V, Kafai MR. Trends in serum folate, RBC folate, and circulating total homocysteine concentrations in the United States: Analysis of data from National Health and Nutrition Examination Surveys, 1988-1994, 1999-2000, and 2001-2002[J]. J Nutr, 2006, 136(1):153-158.
[7]
Daly LE, Kirke PN, Moloy A, et al. Folate levels and neural tube defects.Implications for prevention[J]. JAMA, 1995, 274(21):1698-1702.
[8]
Xiao LY, Wang M, Zhu MW, et al. Determination of serum folate with electrochemiluminescence immunoassay[J]. Chin J Clin Nutr, 2007, 15(2):75-78.
[9]
Bar-Oz B, Koren G, Nguyen P, et al. Folate fortification and supplementation: Are we there yet[J]? Reprod Toxicol, 2008, 25(4):408-412.
[10]
Nicola A, Hursthouse I, Andrew R, et al. Folate status of reproductive age women and neural tube defect risk: The effect of long-term folic acid supplementation at doses of 140 μg and 400 μg per day[J]. Nutrients, 2011, 3:49-62.
[11]
Li ZW, Ren AG, Zhang L, et al. Plasma and red blood cell folate levels among women in their first trimester of neural tube defects[J]. Chin J Epidemiol, 2005, 26(4):252-257.
[12]
Mitchell LE. Epidemiology of neural tube defects[J]. Am J Med Genet C Sem in Med Genet, 2005, 135 (1):88-94.
[13]
Hao L, Tian YH, Zhang FR, et al. Variation of plasma folate levels in adults between some areas and different seasons in China[J]. Chin J Prev Med, 2002, 36(5):308-310.
[1] 钱警语, 郑明明. 《2024意大利妇产科学会非侵入性和侵入性产前诊断指南》解读[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 486-492.
[2] 李康虎, 王继伟, 王光远. 腹腔镜下腹股沟疝修补术后并发症及防治进展[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(04): 369-375.
[3] 邓杨, 彭豪, 刘剑文. 腹腔镜疝修补术腹膜前负压引流的效果和长期安全性研究[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(04): 402-405.
[4] 申亚伟, 黄新, 李万林. 改良医用胶粘合假疝囊技术预防腹腔镜完全腹膜外疝修补术后血清肿的临床研究[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(04): 410-413.
[5] 张庆峰, 邓旭明, 段巧斌, 姚干, 张策. 腹腔镜完全腹膜外斜疝修补手术关闭内环口对血清肿发生率的影响[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(03): 282-290.
[6] 郝智勇, 雷霞, 张国锋, 李锋. 经腹腹膜前疝修补术治疗阴囊疝术后血清肿的相关危险因素分析及预测模型构建[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(03): 291-295.
[7] 张春玉, 陈海云, 肖忠萍, 罗琴, 潘运昌. 血清NT-proBNP 预测肺栓塞心脏功能障碍的临床分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 805-808.
[8] 井发红, 李丽娜, 高婷, 高艳梅, 杨楠, 李卓, 慕玉东. 肺癌立体定向放疗血清SAP 和MMPs 表达及临床意义[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 707-713.
[9] 张龙, 孙善柯, 徐伟, 李文柱, 李俊达, 池涌泉, 何广胜, 成峰, 王学浩, 饶建华. 腹腔镜脾切除治疗血液系统疾病的临床疗效分析[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 870-875.
[10] 刘思含, 张静. 老年人血清铁与C 反应蛋白的比值及25-羟基维生素D3 与肾功能受损的关系研究[J/OL]. 中华肾病研究电子杂志, 2024, 13(05): 268-272.
[11] 王子阳, 王宏宾, 刘晓旌. 血清标志物对甲胎蛋白阴性肝细胞癌诊断的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 677-681.
[12] 杨菲, 刘腾飞, 赵志军, 李睿聪, 张颉, 刘妍, 赵珍. 血清维生素水平与分化型甲状腺癌的关联性研究[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 633-640.
[13] 田峰瑞, 蒋锦源, 李阳, 张连阳. Morel-Lavallée 损伤继发血清肿一例[J/OL]. 中华诊断学电子杂志, 2024, 12(04): 245-248.
[14] 赵方, 邓宇傲, 饶嫚, 刘瑜, 邓秋霞, 张秋月, 张海涛, 宋莹, 王思苑, 贾新云, 刘映霞. HIV/TB 双重感染者发生免疫重建炎性综合征时血清锌及相关炎症因子的变化特征[J/OL]. 中华卫生应急电子杂志, 2024, 10(04): 213-217.
[15] 赵伟伟, 赵玉华, 刘小璇. 西藏地区亚甲基四氢叶酸还原酶C677T多态性及其与脑微出血的相关性[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(05): 473-478.
阅读次数
全文


摘要