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中华妇幼临床医学杂志(电子版) ›› 2012, Vol. 08 ›› Issue (06) : 700 -703. doi: 10.3877/cma.j.issn.1673-5250.2012.06.006

所属专题: 文献

论著

育龄妇女血清叶酸及红细胞叶酸水平检测分析
速存梅1,*,*(), 叶汉风2, 王珏1, 廖戎1, 陈涓涓2, 刘清梅1, 李丽芳1   
  1. 1. 650021 昆明, 云南省人口和计划生育科学技术研究所
    2. 云南省生育调节与少数民族优生研究重点实验室
  • 收稿日期:2012-06-05 修回日期:2012-10-18 出版日期:2012-12-01
  • 通信作者: 速存梅

Analysis of Serum Folic Acid and Red Blood Cell Folic Acid Concentrations Among 261 Childbearing-Aged Women

Cun-mei SU1(), Han-feng YE2, Jue WANG1, Rong LIAO1, Juan-juan CHEN2, Qing-mei LIU1, Li-fang LI1   

  1. 1. Yunnan Population and Family Planning Research Institute of Science and Technology, Kunming 650021, Yunnan Province, China
  • Received:2012-06-05 Revised:2012-10-18 Published:2012-12-01
  • Corresponding author: Cun-mei SU
  • About author:
    (Corresponding author: SU Cun-mei, Email: )
引用本文:

速存梅, 叶汉风, 王珏, 廖戎, 陈涓涓, 刘清梅, 李丽芳. 育龄妇女血清叶酸及红细胞叶酸水平检测分析[J]. 中华妇幼临床医学杂志(电子版), 2012, 08(06): 700-703.

Cun-mei SU, Han-feng YE, Jue WANG, Rong LIAO, Juan-juan CHEN, Qing-mei LIU, Li-fang LI. Analysis of Serum Folic Acid and Red Blood Cell Folic Acid Concentrations Among 261 Childbearing-Aged Women[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2012, 08(06): 700-703.

目的

了解育龄妇女血清叶酸及红细胞叶酸水平,为昆明地区育龄妇女增补叶酸预防神经管畸形(NTDs)等出生缺陷提供参考。

方法

选取2010年1月至2011年10月于本研究所门诊就诊的261例育龄妇女为研究对象。采集其年龄、孕次等相关临床资料(本研究遵循的程序符合云南省人口和计划生育科学技术研究所人体试验委员会所制定的伦理学标准,得到该委员会批准,征得受试者知情同意,并与之签署临床研究知情同意书)。采集受试者空腹静脉血4 mL,采用电化学发光法分别测定血清叶酸及红细胞叶酸水平。以预防NTDs的叶酸推荐值为标准,进行叶酸水平分析。

结果

261例育龄妇女的血清叶酸、红细胞叶酸的平均水平分别为(9.74±3.23)ng/L和(529.79±205.44)ng/L,以试剂盒正常参考值为标准判断标准。本组受试者血清叶酸和红细胞叶酸缺乏率分别为8.43%(22/261)和5.36%(14/261)。若以预防NTDs推荐值为标准进行判断,则本组妇女血清叶酸、红细胞叶酸水平偏低率分别为67.82%(177/261)和73.95%(193/261)。

结论

昆明地区育龄妇女叶酸缺乏率不高,但仍有超过1/2以上育龄妇女的血液叶酸水平低于预防NTDs的推荐值,故对育龄妇女须加强叶酸增补方面的知识普及。

Objective

To investigate the level of serum folic acid, red blood cell (RBC) folic acid among childbearing-aged women and provide information for carrying out suping folic acid to prevent birth defects.

Methods

From January 2010 to October 2011, a total of 261 childbearing-aged women were included into this study. Their age, and related clinical data were collected and analyzed. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Yunnan Population and Family Planning Research Institute of Science and Technology. Informed consent was obtained from each participate. And 4 mL venous blood was drawn. Serum and RBC folic acid concentrations were detected by electrochemiluminescence immunoassay.

Results

The average level of serum folic acid was (9.74±3.23) ng/L and RBC folic acid was (529.79±205.44) ng/L.The prevalence of low serum folic acid and RBC folic acid concentrations were 8.43%(22/261), and 5.36%(14/261), respectively. Taking the optimal level of folic acid to prevent neural tube defects (NTDs) as the determine, the prevalence of low serum folic acid and RBC folic acid concentrations were 67.82%(177/261) and 73.95%(193/261), respectively.

Conclusions

The serum and RBC folic acid levels among more than half of childbearing-aged women in Kunming region below the recommended level for the prevention of NTDs. So the actual intake of folic acid should be strength.

表1 不同年龄段妇女血液叶酸水平比较[ng/L,n(%)]
Table 1 Comparison of folic acid levels among 261 childbearing-aged women at different ages[ng/L,n(%)]
表2 城市与农村育龄妇女叶酸水平比较[ng/L,n(%)]
Table 2 Comparison of folic acid levels among 261 childbearing-aged women from urban and rural [ng/L,n(%)]
表3 不同教育背景妇女叶酸水平比较[ng/L,n(%)]
Table 3 Comparison of folic acid level among 261 childbearing-aged women of different educational levels [ng/L,n(%)]
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