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中华妇幼临床医学杂志(电子版) ›› 2012, Vol. 08 ›› Issue (05) : 654 -657. doi: 10.3877/cma.j.issn.1673-5250.2012.05.034

所属专题: 文献

综述

药物进入乳汁的机制及哺乳期妇女用药安全
陈力1, 赵文艳2, 张伶俐1,*,*(), 张川1   
  1. 1. 610041 成都,四川大学华西第二医院
    2. 中国石油华北油田公司总医院
  • 收稿日期:2012-05-13 修回日期:2012-08-30 出版日期:2012-10-01
  • 通信作者: 张伶俐

The Mechanism of Medicine Into Human Milk and Medication Safety of Lactating Women

Li CHEN1, Wen-yan ZHAO2, Ling-li ZHANG1(), Chuan ZHANG1   

  1. 1. Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2012-05-13 Revised:2012-08-30 Published:2012-10-01
  • Corresponding author: Ling-li ZHANG
  • About author:
    (Corresponding author: ZHANG Ling-li, Email: )
引用本文:

陈力, 赵文艳, 张伶俐, 张川. 药物进入乳汁的机制及哺乳期妇女用药安全[J/OL]. 中华妇幼临床医学杂志(电子版), 2012, 08(05): 654-657.

Li CHEN, Wen-yan ZHAO, Ling-li ZHANG, Chuan ZHANG. The Mechanism of Medicine Into Human Milk and Medication Safety of Lactating Women[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2012, 08(05): 654-657.

哺乳期是女性特殊的生理时期,包括产后42 d内(产褥期)。产褥期母体各系统变化大、抵抗力降低,同时分娩后子宫内有较大创面,易感染和继发其他疾病,需使用药物治疗。但药物可通过母乳进入婴儿体内,故用药期间是否需要停止哺乳,或在有效治疗母亲疾病的同时尽可能减少药物对婴儿的影响,是目前越来越多医师关注的难题。目前对此的临床研究证据较为缺乏,但若对哺乳期妇女用药根据非临床研究结论进行选择,则可将风险降至最低。作者拟就药物进入乳汁机制及哺乳期妇女用药安全的研究进展进行综述如下。

Lactation is a special physiological period for female, including postpartum puerperium. Puerperium Women are needed to be treated with drugs because of maternal system changes, lowered immunity, large wound in the uterus after childbirth, prone to infection and secondary to other diseases. But there has a problem, that is, mothers are usually advised against breast feeding because of drug through human breast milk into baby's body. There are plenty of conclusions about the medicine transportation mechanism, but still lacking research about the clinical trial which could provide the evidence directly. So, lactating women should be medicated based on the theory derived from the mechanism which could minimized the risk for the infant. This article reviewed all the published articles about the conclusions of the medicine transportation mechanism and about medication safely used in lactating women.

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