切换至 "中华医学电子期刊资源库"

中华妇幼临床医学杂志(电子版) ›› 2012, Vol. 08 ›› Issue (04) : 468 -470. doi: 10.3877/cma.j.issn.1673-5250.2012.04.019

所属专题: 文献

论著

高强度聚焦超声治疗子宫肌瘤对卵巢功能的影响
陈衡1,*,*(), 黄耀1, 张卫星1, 李淑杏1, 陈小珍1   
  1. 1. 518033 广东深圳,广东医学院附属深圳福田区人民医院妇产科
  • 收稿日期:2012-02-02 修回日期:2012-07-05 出版日期:2012-08-01
  • 通信作者: 陈衡

Study of Influence on Ovarian Function by HIFU and Surgical Treatment for Uterine Fibroids

Heng CHEN1(), Yao HUANG1, Wei-xing ZHANG1, Shu-xing LI1, Xiao-zhen CHEN1   

  1. 1. Department of Obstetrics and Gynecology, Futian People's Hospital of Shenzhen, Guangdong Medical College, Shenzhen 518033, Guangdong Province, China
  • Received:2012-02-02 Revised:2012-07-05 Published:2012-08-01
  • Corresponding author: Heng CHEN
  • About author:
    (Corresponding author: Chen Heng, Email: )
引用本文:

陈衡, 黄耀, 张卫星, 李淑杏, 陈小珍. 高强度聚焦超声治疗子宫肌瘤对卵巢功能的影响[J/OL]. 中华妇幼临床医学杂志(电子版), 2012, 08(04): 468-470.

Heng CHEN, Yao HUANG, Wei-xing ZHANG, Shu-xing LI, Xiao-zhen CHEN. Study of Influence on Ovarian Function by HIFU and Surgical Treatment for Uterine Fibroids[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2012, 08(04): 468-470.

目的

探讨高强度聚焦超声(HIFU)治疗子宫肌瘤对卵巢功能的影响。

方法

选择2008年1月至2010年12月在本院就诊的90例子宫肌瘤患者为研究对象,按照治疗方式不同将其分为HIFU组(n=30,HIFU治疗),肌瘤剔除组(n=30,子宫肌瘤剔除术)和全子宫切除组(n=30,全子宫切除术)。测定并分析3组患者术前及术后6个月血清卵泡刺激素(FSH)、黄体生成素(LH)和雌二醇(E2)水平变化(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准,得到该委员会批准,并与之签署临床研究知情同意书)。3组患者年龄、临床症状及肌瘤类别方面比较,差异无统计学意义(P>0.05)。

结果

HIFU组和肌瘤剔除组患者术前与术后6个月血清FSH,LH,E2比较,差异无统计学意义(P>0.05)。全子宫切除组患者术后6个月血清FSH,LH明显升高,E2明显下降,与术前相比,差异有统计学意义(P<0.05)。HIFU组与全子宫切除组术后6个月激素水平变化比较,差异有统计学意义(P<0.05)。

结论

HIFU治疗育龄期子宫肌瘤患者对卵巢功能无明显影响。

Objective

To explore the influence on ovarian function by HIFU, myomectomy, and hysterectomy for uterine fibroids.

Methods

From January 2008 to December 2010, 90 women with uterine fibroids were included in the study, and divided into high intensity focused ultrasound (HIFU)group(n=30), myomectomy group(n=30) and hysterectomy group(n=30) according to treatment method. Measure and compare the serum follicle-stimulating hormone (FSH), luteinizing hormone(LH)and estradiol hormone(E2) level changes at 6 months before and after treatment.The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Futian People's Hospital of Shenzhen. Informed consent was obtained from each patient. There has no significant differences between ages, clinical symptom and clinical classification among three groups(P>0.05).

Results

No significant difference was found in hormone levels between preoperative and 6 months after treatment in HIFU group and myomectomy group. 6 months after hysterectomy, FSH, LH increased and E2 decreased which were significant differences compared to preoperative(P<0.05). There had significant differences of hormone level change between HIFU group and hysterectomy group in 6 months after treatment.

Conclusions

HIFU treatment for childbearing age women with uterine fibroids does not influence the ovarian function.

表1 3组患者一般情况比较[n(%)]
Table 1 Comparison of general condition among three groups[n(%)]
表2 3组患者术前及术后6个月激素水平变化比较(±s)
Table 2 Comparison of serum hormone levels among three groups 6 months after treatment(±s)
[1]
Yue J, ed.Obstetrics and gynecology.7th ed[M].Beijing:People's Medical Publishing House, 2008: 269.
[2]
Tu J, Liu M.Clinical application on the treatment of uterine hysteromyomas using high-intensity focused ultrasound[J]. China Med Herald, 2009:35.
[3]
Zhang Y, Yang WW, Li J, et al.The clinical study on single treatment of uterine leiomyoma by high intensity focused ultrasound[J]. Chin J Med Ultrasound:Electron ed, 2009, 6(1):66-72.
[4]
Leeper K, Garcia R, Swisher E, et al. Pathologic findings in prophylactic ophorectomy specimens in high-risk women[J].Gynecol Oncol, 2002, 87:52.
[5]
Basu A, Devara JS, Jialal I, et al.Dietary factors that promote or retard inflammation[J].Arterioscler Thromb Vasc Biol, 2006, 26(5):995-1001.
[6]
Li J, Lu Q. Analysis of clinical long and short term complications of total abdominal hysterectomy:236 cases[J].Chin J Pract Gynecol Obstet, 2003, 19(21):53.
[1] 孙佳丽, 金琳, 沈崔琴, 陈晴晴, 林艳萍, 李朝军, 徐栋. 机器人辅助超声引导下经皮穿刺的体外实验研究[J/OL]. 中华医学超声杂志(电子版), 2024, 21(09): 884-889.
[2] 李刘庆, 陈小翔, 吕成余. 全腹腔镜与腹腔镜辅助远端胃癌根治术治疗进展期胃癌的近中期随访比较[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 23-26.
[3] 刘世君, 马杰, 师鲁静. 胃癌完整系膜切除术+标准D2根治术治疗进展期胃癌的近中期随访研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 27-30.
[4] 李华志, 曹广, 刘殿刚, 张雅静. 不同入路下行肝切除术治疗原发性肝细胞癌的临床对比[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 52-55.
[5] 常小伟, 蔡瑜, 赵志勇, 张伟. 高强度聚焦超声消融术联合肝动脉化疗栓塞术治疗原发性肝细胞癌的效果及安全性分析[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 56-59.
[6] 韩戟, 杨力, 陈玉. 腹部形态CT参数与完全腹腔镜全胃切除术术中失血量的关系研究[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 88-91.
[7] 王露, 周丽君. 全腹腔镜下远端胃大部切除不同吻合方式对胃癌患者胃功能恢复、并发症发生率的影响[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 92-95.
[8] 孙一娇, 包润发, 董平, 束翌俊. PBL结合手术视频剪辑教学在普通外科专科医师规范化培训中的应用与思考[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 96-99.
[9] 陈浩, 王萌. 胃印戒细胞癌的临床病理特征及治疗选择的研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 108-111.
[10] 孙莲, 马红萍, 吴文英. 局部进展期甲状腺癌患者外科处理[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 112-114.
[11] 刘柏隆. 女性压力性尿失禁阶梯治疗之手术治疗方案选择[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2025, 19(01): 126-126.
[12] 刘柏隆, 周祥福. 女性尿失禁吊带手术并发症处理的经验分享[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2025, 19(01): 127-127.
[13] 周迪, 全志伟. 规范化胆囊良性疾病诊治流程减少胆囊癌误诊误治[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 749-753.
[14] 张宗明, 董家鸿, 何小东, 王秋生, 徐智, 刘立民, 张翀. 老年胆道外科热点问题的争议与思考[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 754-762.
[15] 张耕毓, 唐冲, 张昆, 张辉, 张清华, 刘家帮. 股骨头坏死髓芯减压术的文献计量学分析及单中心病例报道[J/OL]. 中华临床医师杂志(电子版), 2024, 18(08): 771-780.
阅读次数
全文


摘要