子痫前期患者血清脂联素与血脂因子水平的测定及意义

doi:10.3877/cma.j.issn.1673-5250.2012.01.004

中华妇幼临床医学杂志(电子版) ›› 2012, Vol. 08 ›› Issue (01) : 15 -17. doi: 10.3877/cma.j.issn.1673-5250.2012.01.004

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论著

子痫前期患者血清脂联素与血脂因子水平的测定及意义

孙萍¹^,^*^,^*(

), 荆玉慧¹, 李健¹, 位菊峰¹, 张雪茹¹, 于华¹

^1. 266042　山东青岛，青岛大学医学院第二附属医院（青岛市中心医院）妇产科

收稿日期:2011-09-03 修回日期:2011-12-16 出版日期:2012-02-01
通信作者: 孙萍

Levels and Significance of Adiponectin and Lipoproteins in Serum of Preeclampsia

Ping SUN¹(), Yu-hui JING¹, Jian LI¹, Ju-feng WEI¹, Xue-ru ZHANG¹, Hua YU¹

^1. Department of Obstetrics and Gynecology, Second Affiliated Hospital of Qingdao Medical University(Qingdao Central Hospital), Qingdao 266042, Shandong Province, China

Received:2011-09-03 Revised:2011-12-16 Published:2012-02-01
Corresponding author: Ping SUN
About author:
Corresponding author: SUN Ping, Email: dingbosd@163.com

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目的

探讨孕晚期子痫前期(PE)患者血清脂联素(APN)与血脂因子水平的变化及其临床意义。

方法

选取2009年10月至2010年10月于青岛市中心医院产科确诊为PE的40例孕妇为研究对象，纳入PE组。再按照PE病情分级[轻度子痫前期(MPE)和重度子痫前期(SPE)]，将其分别纳入MPE组(n＝18)和SPE组(n＝22)。选择同期于本院就诊的40例健康孕妇纳入对照组。所有纳入对象孕龄为34～38孕周。采用放射免疫吸附法(RIA)测定血清APN、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)和高密度脂蛋白(HDL)含量，并进行相关统计学处理(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准，得到该委员会批准，分组征得受试对象本人的知情同意，并与之签署临床研究知情同意书)。PE组与对照组及MPE组与SPE组的胎次(均为第1胎)、孕晚期体重、既往特殊病史及其他妊娠合并症和并发症分别比较，差异无统计学意义(P>0.05)。

结果

①PE组血清APN和HDL水平明显低于对照组，TG水平显著高于对照组，差异均有统计学意义(P<0.01)。②PE组患者血清APN水平与TG水平呈显著负相关关系(r＝－0.90，P<0.01)，而与HDL水平呈显著正相关关系(r＝0.93，P<0.01)。

结论

孕晚期血清APN水平降低和脂质代谢紊乱可能与PE发病有关。

关键词: 子痫前期, 脂联素, 脂蛋白

Objective

To explore the relationship between adiponectin (APN) and lipoproteins in the late pregnancy women with preeclampsia (PE).

Methods

From October 2008 to October 2010, a total of 40 cases of pregnancy women with PE were admitted in the Second Affiliated Hospital of Qingdao Medical University as PE group. According to severity grading of PE [severe preeclampsia (SPE) and mild preeclampsia(MPE)], they were divided into SPE group(n=22) and MPE group(n=18). Meanwhile another 40 healthy pregnancy women gestational ages as control group. The levels of serum APN, total triglyceride(TG), cholesterin(TC), low density lipoprotein(LDL)and high density lipoprotein (HDL) in 80 pregnant women at 34~38 weeks were measured with radioimmunoassay(RIA). There had no significant differences between PE group and control group, MPE group and SPE group among ages, gestational ages, parities(all first born), pregnant weight in late pregnancy, special past medical history and other pregnancy complications (P>0.05). This was a prospective observational study with institutional ethics approval and written subjects consent.

Results

①The levels of serum APN and HDL were significantly lower in PE group than those in control group(P<0.01). The TG level was significantly higher in PE group than that in control group(P<0.01). ②The levels of APN and TG were negative correlated in PE group(r=-0.90, P<0.01). The levels of APN and HDL were positive correlated in PE group(r=0.93, P<0.01).

Conclusions

Lower APN and disturbance of lipid metabolism in late pregnancy might be associated with the pathogenesis of PE.

Key words: preeclampsia, adiponectin, lipoprotein

表1 PE组与对照组一般情况比较(±s)

Table 1 Comparison of general clinical data between PE group and control group(±s)

组别	n	年龄(岁)	孕龄(孕周)	孕晚期体重(kg)
PE组	40	29.15±4.51	36.90±2.87	82.45±13.45
对照组	40	28.83±2.25	38.11±3.95	78.87±10.20
t	?	0.4016	1.5674	1.3413
P	?	0.6891	0.1211	0.1837

表1 PE组与对照组一般情况比较(±s)

Table 1 Comparison of general clinical data between PE group and control group(±s)

组别	n	年龄(岁)	孕龄(孕周)	孕晚期体重(kg)
PE组	40	29.15±4.51	36.90±2.87	82.45±13.45
对照组	40	28.83±2.25	38.11±3.95	78.87±10.20
t	?	0.4016	1.5674	1.3413
P	?	0.6891	0.1211	0.1837

表2 PE组与对照组血清APN，TG，TC，HDL及LDL水平比较 (±s)

Table 2 Comparison of levels of serum APN, TG, TC, HDL and LDL between PE group and control group (±s)

组别	n	APN(mg/mL)	TG(mmol/L)	TC(mmol/L)	HDL(mmol/L)	LDL(mmol/L)
PE组	40	9.65±1.87	5.76±1.32	4.96±0.92	1.64±0.32	3.52±0.98
对照组	40	12.33±1.65	4.98±1.08	4.73±0.87	2.08±0.51	3.14±0.81
t	?	6.7966	2.8925	1.1488	4.6220	1.8900
P	?	0.0000	0.0050	0.2541	0.0000	0.0624

表2 PE组与对照组血清APN，TG，TC，HDL及LDL水平比较 (±s)

Table 2 Comparison of levels of serum APN, TG, TC, HDL and LDL between PE group and control group (±s)

组别	n	APN(mg/mL)	TG(mmol/L)	TC(mmol/L)	HDL(mmol/L)	LDL(mmol/L)
PE组	40	9.65±1.87	5.76±1.32	4.96±0.92	1.64±0.32	3.52±0.98
对照组	40	12.33±1.65	4.98±1.08	4.73±0.87	2.08±0.51	3.14±0.81
t	?	6.7966	2.8925	1.1488	4.6220	1.8900
P	?	0.0000	0.0050	0.2541	0.0000	0.0624

表3 MPE组与SPE组血清APN，TG，TC，HDL及LDL水平比较 (±s)

Table 3 Comparison of levels of serum APN, TG, TC, HDL and LDL between MPE group and SPE group (±s)

组别	n	APN(mg/mL)	TG(mmol/L)	TC(mmol/L)	HDL(mmol/L)	LDL(mmol/L)
MPE组	18	11.14±1.17	5.51±0.36	4.95±0.27	1.81±0.13	3.49±0.47
SPE组	22	6.51±1.50	5.98±0.63	4.97±0.33	1.50±0.07	3.55±0.59
t	?	10.9524	2.8004	0.2721	9.7599	0.3586
P	?	0.0000	0.0080	0.7870	0.0000	0.7219

表3 MPE组与SPE组血清APN，TG，TC，HDL及LDL水平比较 (±s)

Table 3 Comparison of levels of serum APN, TG, TC, HDL and LDL between MPE group and SPE group (±s)

组别	n	APN(mg/mL)	TG(mmol/L)	TC(mmol/L)	HDL(mmol/L)	LDL(mmol/L)
MPE组	18	11.14±1.17	5.51±0.36	4.95±0.27	1.81±0.13	3.49±0.47
SPE组	22	6.51±1.50	5.98±0.63	4.97±0.33	1.50±0.07	3.55±0.59
t	?	10.9524	2.8004	0.2721	9.7599	0.3586
P	?	0.0000	0.0080	0.7870	0.0000	0.7219

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