调查四川省绵阳地区儿童急性胃肠炎中诺如病毒(NV)感染情况，并对其临床资料进行分析总结。

本院2010年1月至12月共收集650例排除轮状病毒及细菌感染导致儿童急性胃肠炎的大便标本为研究对象。采用前瞻性研究方法，检测NV抗原呈阳性标本，并详细记录650例患儿的临床资料，包括年龄、发热、呕吐、腹泻、腹痛及病程等情况(本研究遵循的程序符合本院人体试验委员会制订的伦理学标准，研究得到该委员会的批准，并与受试对象监护人签署临床研究知情同意书)。

自650例儿童急性胃肠炎大便标本中，检查出NV抗原呈阳性标本为204例，NV抗原阳性检出率为31.38%。NV感染患儿的年龄为1~114个月(P₂₅＝7.00；P₅₀＝9.00；P₇₅＝13.75; Meadian＝9，Mode＝8)。2010年绵阳地区NV感染高发年龄为6~12个月，高发季节为夏季(8~10月)，临床表现仅呕吐症状相对较突出。

绵阳地区儿童NV感染较常见，夏季发病率较高，临床表现除呕吐症状相对较突出外，其余症状与其他急性胃肠炎难于区分。

To investigate the situation of children with norovirus (NV)gastroenteritis in Mianyang region, Sichuan Province.

This was a prospective observational study with instrutional ethics approval and written parents consent. Stool specimens of children with acute gastroenteritis (excluded rotavirus and bacterial enteritis) were collected during January to December 2010 in Mianyang Central Hospital, and clinical data, including children age, fever, vomiting, diarrhea, abdominal pain and disease conditions were analyzed.

A total of 650 cases were collected, and 204 (31.38%) of them were confirmed with NV antigen-positive. The NV infection children was at age of 1-114 months (P₂₅=7.00; P₅₀=9.00; P₇₅=13.75; Meadian=9, Mode=8). The high incidence of NV was at the age of 6 to 12 months, and the summit season was summer (from August to October). Vomit was the dominant symptom in children with NV gastroenteritis(χ²=22.954, P=0.00).

NV gastroenteritis is more common in summer in Mianyang region, and vomit is more frequently occurred in NV gastroenteritis, other clinical symptoms which were difficult to distinguish with other acute gastroenteritis.