切换至 "中华医学电子期刊资源库"

中华妇幼临床医学杂志(电子版) ›› 2011, Vol. 07 ›› Issue (06) : 555 -557. doi: 10.3877/cma.j.issn.1673-5250.2011.06.010

论著

中至重度肥胖儿童尿酸水平与糖脂代谢相关性研究
鄢力, 程昕然, 魏艳, 王晓鸥, 何卫兰, 向蓉, 曾欢欢   
  1. 610091 成都,成都市妇女儿童中心医院
  • 出版日期:2011-12-01

Correlation Study on Blood Uric Acid Level and Glycometabolism and Lipid Metabolism in Moderate and Severe Obesity Children

Li YAN, Xin-ran CHENG, Yan WEI, Xiao-ou WANG, Wei-lan HE, Rong XIANG, Huan-huan ZENG   

  1. Chengdu Women and Children's Centre Hospital, Chengdu 610091, Sichuan Province, China
  • Published:2011-12-01
引用本文:

鄢力, 程昕然, 魏艳, 王晓鸥, 何卫兰, 向蓉, 曾欢欢. 中至重度肥胖儿童尿酸水平与糖脂代谢相关性研究[J/OL]. 中华妇幼临床医学杂志(电子版), 2011, 07(06): 555-557.

Li YAN, Xin-ran CHENG, Yan WEI, Xiao-ou WANG, Wei-lan HE, Rong XIANG, Huan-huan ZENG. Correlation Study on Blood Uric Acid Level and Glycometabolism and Lipid Metabolism in Moderate and Severe Obesity Children[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2011, 07(06): 555-557.

目的

探讨中至重度肥胖儿童尿酸(UA)水平与糖脂代谢之间的关系。

方法

选择2006年1月至2010年12月在本院内分泌代谢专科门诊和病区就诊并确诊的74例肥胖儿童为研究对象。其中,男性患儿为45例,女性为29例;年龄为2.7~16.6岁。诊断标准:体重指数(BMI)超过同年龄、同性别儿童95百分位(P95,诊断为肥胖,以BMI超过同年龄、同性别儿童的30%,则诊断为中度肥胖,若超过40%,则诊断为重度肥胖。纳入标准:入选儿童既往均无严重肝、肾损害和使用影响UA的药物史。按照UA水平将其分为高UA水平组(n=24,UA>416 μmol/L)和正常UA水平组(n=50,UA≤416 μmol/L)(本研究遵循的程序符合本院人体试验委员会制定的伦理学标准,得到该委员会批准,分组征得受试对象监护人的知情同意,并与其签署临床研究知情同意书)。两组患儿性别、年龄等比较,差异无显著意义(P>0.05)。分别检测两组儿童BMI、空腹血糖(FBG)、空腹血胰岛素(FINS)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及UA,并计算血糖/胰岛素比值(G/I)、稳态模型评估的胰岛素抵抗指数(HOMA-IR)和稳态模型评估的胰岛素敏感性(HOMA-IS),TG及HDL-C比值(TG/HDL-C)。

结果

高UA水平组FBG,G/I,TG,TC,HDL,LDL和TG/HDL-C与正常UA水平组比较,差异无统计学意义(P>0.05),而两组FINS,HOMA-IR和HOMA-IS比较,差异有统计学意义(P<0.05)。

结论

中至重度肥胖儿童合并高尿酸血症(HUA)与胰岛素敏感性密切相关,肥胖儿童需早期干预和长期随访血UA浓度。

Objective

To investigate the relationship between uric acid(UA) level and glycometabolism and lipid metabolism in moderate and severe obesity children.

Methods

From January 2006 to December 2010, a total of 74 children aged 2.7-16.6 years-old who were diagnosed as obesity were recruited in this study, including 45 boys and 29 girls. The diagnostic criteria were: body mass index (BMI)>P95 diagnosis as obesity, moderate obesity: BMI>30% average and severe obesity: BMI>40% average. Both groups excluded severe hepatic and kidney lesion and the drug which would influence UA. According to the level of UA, the moderate and severe obesity children were divided into high level UA group (n=24, UA>416 μmol/L)and normal level UA group(n=50, UA≤ 416 μmol/L). Informed consent was obtained from all participates. There were no significant difference in gender and age between two groups (P>0.05). The BMI, fasting blood glucose (FBG), fasting insulin (FINS), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and UA were tested, and glucose/insulin (G/I), homeostasis model assessment-insulin resistance index (HOMA-IR), homeostasis model assessment insulin sensitive index (HOMA-IS) and TG/HDL-C were calculated.

Results

There were no significant differences in FBG, G/I, TG, TC, HDL, LDL and TG/HDL-C between two groups(P>0.05), and FINS, HOMA-IR and HOMA-IS in high level UA group were significant higher than those of normal level UA group(P<0.05).

Conclusion

Insulin sensitivity is closely related to the incidence of hyperuricemia in moderate and severe obesity child. It is necessary to follow up and intervene in early the level of blood UA in moderate and severe obesity children.

1 Ji CY,Sun JL,Chen TJ.Dynamic analysis on the prevalence of obesity and overweight school-age children and adolescents in recent 15 years in China [J]. Chin J Epidemiol, 2004, 25(2): 103-108. [季成叶,孙军玲,陈天娇. 中国学龄儿童青少年1985~2000年超重、肥胖流行趋势动态分析 [J]. 中华流行病学杂志,2004, 25(2): 103-108.]
2 Ford ES, Li C, Cook S, et al. Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents[J].Circulation, 2007, 115(19): 2526-2532.
3 Li H, Ji CY, Zong XN, et al. Body mass index growth curves for Chinese children and adolescents aged 0-18 years old [J]. Chin J Pediatr, 2009, 47(7): 493-498. [李辉,季成叶,宗心南,等.中国0~18岁儿童、青少年体块指数的生长曲线[J].中华儿科杂志,2009, 47(7):493-498.]
4 Zeng JS, Wang DF, ed. Contemporary pediatric endocrinology: Basic and clinics [M]. Shanghai: Shanghai Science and Technology Literature Publishing House, 2001, 400. [曾畿生,王德芬,主编.现代儿科内分泌学-基础与临床[M].上海:上海科学技术文献出版社,2001, 400.]
5 Hu YM, Jiang ZF, ed. Zhu Fu-tang textbook of pediatrics. 7th ed [M]. Beijing: People's Medical Publishing House, 2002, 2687. [胡亚美,江载芳,主编.诸福棠实用儿科学.7版[M]. 北京:人民卫生出版社,2002, 2687.]
6 Fang QY, Wan YP. Advances in study on hyperuricemia of obese children [J]. Chin J Woman Child Health Res, 2009, 20(5): 588-591. [方启宇,万燕萍.肥胖儿童高尿酸血症的研究进展 [J].中国妇幼健康研究,2009, 20(5): 588-591.]
7 Oyama C, Takahashi T, Oyamada M, et al. Serum uric acid as an obesity-related indicator in early adolescence [J]. Tohoku J Exp Med, 2006, 209(3): 257-262.
8 Chen LK, Lin MH, Lai HY, et al. Uric acid:A surrogate of insulin resistance in older women [J]. Maturitas, 2008, 59(1): 55-61.
9 Pacifico L, Cantisani V, Anania C, et al. Serum uric acid and its association with metabolic syndrome and carotid atherosclerosis in obese children [J]. Eur J Endocrinol, 2009, 160: 45-52.
10 Clausen JO, Borch-Johnsen K, Ibsen H, et al. Analysis of the relationship between fasting serum uric acid and the insulin sensitivity index in a population-63-69.
11 Daudon M, Traxer O, Conort P, et al. Type 2 diabetes increases the risk for uric acid stones[J].J Am Soc Ncphrol, 2006, 17(7): 2026-2033.
12 Furukawa S, Fujita T, Shimabukuro M, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome [J]. J Clin Invest, 2004, 114:1752-1761.
13 Maliavskaia SI, Lebedev AV, Temovskaia VA. Chronic asymptomatic hyperuricemia as a marker of atherogenic risk in children [J]. Kardiologiia,2007, 47(3): 62-66.
14 Wang Y, Cai WX, Niu FH, et al. Correlation among plasma homocysteine, oxidized low-density lipoprotein, malondialdehyde, and body mass index in obese children [J/CD]. Chin J Obstet Gynecol Pediatr (Electron Ed), 2010, 6(2): 96-99. [王瑜 蔡文仙 牛峰海,等.血清同型半胱氨酸与肥胖儿童氧化低密度脂蛋白、丙二醛及体重指数的相关性 [J/CD]. 中华妇幼临床医学杂志:电子版,2010, 6(2): 96-99.]
15 Sui X, Church TS, Meriwether RA, et al. Uric acid and the development of metabolic syndrome in women and men [J]. Metabolism, 2008, 57: 845-852.
16 Dehghan A, van Hoek M, Sijbrands EJ, et al. High serum uric acid as a novel risk factor for type 2 diabetes[J]. Diabet Care, 2008, 31: 361-362.
[1] 陶宏宇, 叶菁菁, 俞劲, 杨秀珍, 钱晶晶, 徐彬, 徐玮泽, 舒强. 右心声学造影在儿童右向左分流相关疾病中的评估价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(10): 959-965.
[2] 刘琴, 刘瀚旻, 谢亮. 基质金属蛋白酶在儿童哮喘发生机制中作用的研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 564-568.
[3] 向韵, 卢游, 杨凡. 全氟及多氟烷基化合物暴露与儿童肥胖症相关性研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(05): 569-574.
[4] 王雅楠, 刘丹, 曹正浓, 贾慧敏. 儿童迟发性先天性膈疝患儿的临床诊治特点分析[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(04): 410-419.
[5] 陈桂华, 钟小玲, 谢雨, 王慧, 谢江, 杨涛毅. 合并肝脏疾病特殊健康状态儿童疫苗预防接种及时性临床分析[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(04): 431-439.
[6] 郑宝英, 黄小兰, 贾楠, 朱春梅. 儿童难治性肺炎支原体肺炎早期预警指标[J/OL]. 中华实验和临床感染病杂志(电子版), 2024, 18(04): 215-221.
[7] 刘冉佳, 崔向丽, 周效竹, 曲伟, 朱志军. 儿童肝移植受者健康相关生存质量评价的荟萃分析[J/OL]. 中华移植杂志(电子版), 2024, 18(05): 302-309.
[8] 玉素江·图荪托合提, 韩琦, 麦麦提艾力·麦麦提明, 黄旭东, 王浩, 克力木·阿不都热依木, 艾克拜尔·艾力. 腹腔镜袖状胃切除或联合食管裂孔疝修补术对肥胖症合并胃食管反流病的中期疗效分析[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(05): 501-506.
[9] 丁荷蓓, 王珣, 陈为国. 七氟烷吸入麻醉与异丙酚静脉麻醉在儿童腹股沟斜疝手术中的应用比较[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(05): 570-574.
[10] 刘见, 杨晓波, 何均健, 等. 应用电钩三孔法腹腔镜袖状胃切除术[J/OL]. 中华腔镜外科杂志(电子版), 2024, 17(06): 363-364.
[11] 中华医学会器官移植学分会, 中华医学会外科学分会外科手术学学组, 中华医学会外科学分会移植学组, 华南劈离式肝移植联盟. 劈离式供肝儿童肝移植中国临床操作指南[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 593-601.
[12] 刘军, 丘文静, 孙方昊, 李松盈, 易述红, 傅斌生, 杨扬, 罗慧. 在体与离体劈离式肝移植在儿童肝移植中的应用比较[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 688-693.
[13] 张琛, 秦鸣, 董娟, 陈玉龙. 超声检查对儿童肠扭转缺血性改变的诊断价值[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(06): 565-568.
[14] 陈晓胜, 何佳, 刘方, 吴蕊, 杨海涛, 樊晓寒. 直立倾斜试验诱发31 秒心脏停搏的植入心脏起搏器儿童一例并文献复习[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(05): 488-494.
[15] 曹亚丽, 高雨萌, 张英谦, 李博, 杜军保, 金红芳. 儿童坐位不耐受的临床进展[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(05): 510-515.
阅读次数
全文


摘要