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中华妇幼临床医学杂志(电子版) ›› 2011, Vol. 07 ›› Issue (04) : 371 -374. doi: 10.3877/cma.j.issn.1673-5250.2011.04.025

综述

自然杀伤T细胞与支气管哮喘的研究进展
卢燕鸣   
  1. 200001 上海,上海交通大学医学院附属仁济医院儿科
  • 出版日期:2011-08-01

Research Progress of Natural Killer T Cells and Bronchial Asthma

Yan-ming LU   

  1. Department of Pediatrics, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China
  • Published:2011-08-01
  • Supported by:
    * Project No. 2010HX003, supported by the Horizontal Project of Shanghai Jiao Tong University
引用本文:

卢燕鸣. 自然杀伤T细胞与支气管哮喘的研究进展[J]. 中华妇幼临床医学杂志(电子版), 2011, 07(04): 371-374.

Yan-ming LU. Research Progress of Natural Killer T Cells and Bronchial Asthma[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2011, 07(04): 371-374.

自然杀伤(natural killer,NK)T细胞是一种同时具有自然杀伤细胞和T细胞部分表型及功能的细胞亚群,能将先天性免疫应答和获得性免疫应答连接起来,限制性识别CD1d糖脂抗原,并通过调节细胞因子的分泌,影响辅助性T细胞1型(T help cell type 1,Th1)/Th2平衡,广泛参与免疫调节。近年研究发现,自然杀伤T细胞对哮喘Th1/ Th2失衡及气管高反应(airway hyper responsiveness, AHR)产生起重要作用。本研究就自然杀伤T细胞的特征及其与支气管哮喘关系的最新研究进展,综述如下。

Natural killer T(NKT)cells are a unique subset of lymphocytes, which express both T and natural killer(NK) cell surface markers as well as functional characteristics.They connect innate and acquired immunity, restrictedly recognize glycolipid antigens presented by CD1d molecule and influence the balance between T helper cell type 1 (Th1)and Th2 by regulating the secretion of cytokines. Natural killer T cells participate in the immune regulation generally. Focus on recent years found that natural killer T cells played important roles in Th1/Th2 imbalance and airway hyper responsiveness (AHR) of asthma.This paper reviewed the progress of the characteristics of natural killer T cells and the association with bronchial asthma.

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