22例乳汁淤积和乳腺炎患者乳汁的细菌培养结果分析

doi:10.3877/cma.j.issn.1673-5250.2010.06.015

目的

探讨乳汁淤积及乳腺炎患者乳汁细菌培养结果。

方法

随机选取本院2007年11月至2008年4月诊断为单侧乳汁淤积患者(n＝7)和单侧哺乳期乳腺炎患者(n＝15)，共计22例为研究对象。收集其双侧乳汁行普通细菌培养(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准，得到该委员会批准，征得受试对象本人的知情同意，并与之签署临床研究知情同意书)。

结果

22例患者的乳汁普通细菌培养结果显示，4例患者(乳汁淤积患者为1例，乳腺炎患者为3例)患、健侧乳汁中，均未培养出细菌；其余18例(乳汁淤积患者6例，乳腺炎患者12例)的乳汁培养出细菌，其中，16例双侧乳汁的细菌培养结果完全一致，金黄色葡萄球菌和表皮葡萄球菌常见，2例双侧乳汁的细菌培养结果不一致。

结论

乳汁淤积和乳腺炎患者乳汁中可培养出细菌，以葡萄球菌最常见。母乳喂养时，应尽量避免乳汁淤积，预防乳腺炎，同时若新生儿有感染征象，需对其母亲乳汁行细菌培养。

关键词: 乳腺炎, 乳汁淤积, 细菌培养, 葡萄球菌

Objective

To analyze and sum up the milk of siltation and mastitis bacterial culture results in patients with features.

Methods

Randomly selected in Haidian Maternal and Child Health Hospital from November 2007 to April 2008 both siltation cases (n=7) and mastitis cases (n=15) diagnosed with breast milk of 22 patients to make milk-line general bacterial culture. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Haidian Maternal and Child Health Hospital. Informed consent was obtained from all participants.

Results

The average bacterial culture was negative in patients with a total of 4 cases, including patients with 1 case of milk siltation, and 3 cases of mastitis. The positive result was 18 cases, of which 6 cases of milk siltation, 12 cases of mastitis; Of these, 16 cases of bacterial culture was entirely consistent with bilatera and 2 cases was inconsistent. Staphylococcus aureus and Staphylococcus epidermidis were the dominant microogranisms.

Conclusion

It can be developed bacterial in the milk of patients with siltation and mastitis, Staphylococcus aureus is the most common, and we try to avoid milk siltation and prevent the occurrence of mastitis when breastfeeding, It's need to making milk-line general bacterial culture once the signs of neonatal infection.

Key words: mastitis, milk siltation, bacterial culture, Staphylococcus aureus

	1　Huang JF, ed. Modern surgery[M]. Beijing: People's Military Medical Press, 2003，606.[黄洁夫，主编．现代外科学[M]．北京：人民军医出版社，2003，606.]
	2　Nordeng H, Tufte E, Nylander G. Treatment of mastitis in general practice[J]. Tidsskr Nor Laegeforen, 2003，123(21)：3027-3030.
	3　Kotiw M, Zhang GW, Daggard G, et al. Late-onset and recurrent neonatal group B streptococcal disease associated with breast-milk transmission[J]. Pediatr Dev Pathol，2003，6(3)：251-256.
	4　Gastelum DT, Dassey D. Transmission of community-associated methicillin-resistant Staphylococcus aureus from breast milk in the neonatal intensive care unit[J]. Pediatr Infect Dis J，2005，24(12)：1122-1124.
	5　Kawada M, Okuzumi K, Hitomi S, et al.Transmission of Staphylococcus aureus between healthy, lactating mothers and their infants by breastfeeding[J]. J Hum Lact, 2003，19(4)：411-417.
	6　Wang LY, Chen CT, Liu WH, et al. Recurrent neonatal group B streptococcal disease associated with infected breast milk[J]. Clin Pediatr (Phila)，2007，46(6)：547-549.
	7　Bingen E, Denamur E, Lambert-Zechovsky N, et al. Analysis of DNA restriction fragment length polymorphism extends the evidence for breast milk transmission in Streptococcus agalactiae late-onset neonatal infection[J]．Pediatr Infect Dis J, 2002，21(6)：567-568.
	8　Hale TW, Bateman TL, Finkelman MA, et al. The absence of Candida albicans in milk samples of women with clinical symptoms of ductal candidiasis[J]. Breastfeed Med, 2009，4(2)：57-61.
	9　Fragkou IA, Mavrogianni VS, Cripps PJ, et al. The bacterial flora in the teat duct of ewes can protect against and can cause mastitis[J]. Vet Res, 2007，38(4)：525-545.
	10　Coates MM, Riordan J. Breastfeeding during maternal or infant illness. NAACOGS Clin Issu Perinat Women Health Nurs[J]. 1992，3(4)：683-694.
	11　Wilson-Clay B. Case report of methicillin-resistant Staphylococcus aureus (MRSA) mastitis with abscess formation in a breastfeeding woman[J]. J Hum Lact, 2008，24(3)：326-329.
	12　Fernández L, Delgado S, Herrero H, et al. The bacteriocin nisin, an effective agent for the treatment of staphylococcal mastitis during lactation[J]. J Hum Lact，2008，24(3)：311-316.

[1]	杨桂清, 孟静静. 哺乳期亚临床乳腺炎的研究进展[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 376-379.
[2]	刘涵, 刘晓菲, 陈翰翰, 陈延君, 张雁. 妊娠期肉芽肿性乳腺炎一例[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(04): 253-254.
[3]	王培蕾, 夏罕生, 俞清, 闻捷先, 黄备建. IgG4相关性乳腺炎多模态影像学表现及其治疗转归一例[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(04): 244-247.
[4]	蔡健, 刘泽宇, 李红, 张元, 郑希, 汤天燕, 赖娜, 何润泽, 华平, 宁平. 囊性中性粒细胞性肉芽肿性乳腺炎与棒状杆菌感染的关系[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(01): 57-59.
[5]	王思思, 金晶, 汪婕. 初产妇哺乳期乳腺炎发生的影响因素及风险模型构建[J/OL]. 中华乳腺病杂志(电子版), 2023, 17(05): 272-276.
[6]	韩猛虎, 莫浩波, 曹梦瑶, 李基业, 宇文谦. 腺体扩大切除联合腹腔镜游离帯蒂大网膜乳房成形术治疗难治型肉芽肿性乳腺炎2例[J/OL]. 中华乳腺病杂志(电子版), 2023, 17(01): 60-63.
[7]	刘莉, 王清良, 黄婷, 林子晶, 曾斌, 史艳玲, 明佳. 浆细胞性乳腺炎合并导管内癌一例[J/OL]. 中华乳腺病杂志(电子版), 2022, 16(06): 385-388.
[8]	孙珂, 李嗣杰, 陈奕蒙, 毕丽荣, 范志民. 淋巴细胞性乳腺炎一例并文献复习[J/OL]. 中华乳腺病杂志(电子版), 2022, 16(03): 193-195.
[9]	陶新楠, 徐毅, 刘晓青, 刘世佳, 张亚芬. 克氏棒状杆菌在肉芽肿性乳腺炎中的研究进展[J/OL]. 中华乳腺病杂志(电子版), 2022, 16(03): 175-178.
[10]	张利, 张阳, 马菁菁, 喻哲昊, 葛亮, 孙林春. 细胞壁锚定蛋白SasX调控RNAⅢ参与金黄色葡萄球菌ST239克隆生物膜形成及致病性相关研究[J/OL]. 中华实验和临床感染病杂志(电子版), 2023, 17(04): 252-259.
[11]	王守豪, 陈汉竹, 马天时, 童永喜, 周哲雯, 徐成安, 杨兴娣, 任文雅, 潘红英. 结核硬脂酸棒状杆菌致肉芽肿性乳腺炎合并下肢结节性红斑一例并文献复习[J/OL]. 中华实验和临床感染病杂志(电子版), 2023, 17(01): 55-59.
[12]	张红凯, 崔建春. 从病理角度学习非哺乳期乳腺炎的分类分型及治疗[J/OL]. 中华普通外科学文献(电子版), 2023, 17(04): 251-251.
[13]	乔艳艳, 韩璐瑶, 王在强, 冯艳珍, 李婵, 李玉娟, 金发光, 傅恩清. 环介导恒温扩增芯片法在下呼吸道感染病原体检测中的临床应用[J/OL]. 中华肺部疾病杂志(电子版), 2022, 15(04): 477-480.
[14]	林舒楠, 党文强, 钟天, 梁斯欣, 张磊, 唐晓华, 袁文常. 2017—2021年广东地区基层医疗机构金黄色葡萄球菌临床分离株耐药谱分析[J/OL]. 中华临床实验室管理电子杂志, 2023, 11(03): 139-144.
[15]	孙丹, 姬会春, 祝宇翀, 单宇, 刘军权, 廖雨琴. 三叶青提取物TH-w3对金黄色葡萄球菌生物膜的抑制和清除作用[J/OL]. 中华临床实验室管理电子杂志, 2022, 10(04): 227-232.

阅读次数

全文

摘要

选择文件类型/文献管理软件名称

选择包含的内容

Analysis of Results of Milk's Bacterial Culture Among 22 Cases of Mastitis and Milk Siltation

模态框（Modal）标题

选择文件类型/文献管理软件名称

选择包含的内容

Analysis of Results of Milk's Bacterial Culture Among 22 Cases of Mastitis and Milk Siltation