探讨缺氧诱导因子1α(hypoxia inducible factor 1α，HIF-1α)在缺氧和(或)缺血性脑损伤时的表达、分布和意义。

建立生后10 d龄SD大鼠单纯缺氧、单纯缺血和缺氧缺血3个模型组，并同时设立假手术组，利用免疫组织化学方法检测各模型组脑组织中，HIF-1α的表达和分布特点。

相对于假手术组，3个实验组的HIF-1α表达，在模型建立后4 h开始升高，单纯缺氧组和缺氧缺血组，HIF-1α于模型建立后8 h达高峰，单纯缺血组，则在24 h达高峰，以后逐渐下降。HIF-1α主要分布于脑的重要功能区，如皮质和海马。

不同程度的缺氧和缺血对HIF-1α调节存在差异，缺氧缺血性脑损伤后，HIF-1α的表达和分布具有一定特点，这可能与损伤后的修复存在一定关系。

To investigate the expression, distribution and significance of hypoxia inducible factor la (HIF-1α) following exposure to hypoxia and (or) ischemia in newborn rats.

Postnatal 10 days SD rats underwent hypoxia, ischemia, hypoxia-ischemia, or sham surgery. HIF-1α expression and distribution were detected with immunohistochemistry.

HIF-1α expression significantly increased at 4 h following hypoxia, ischemia, or hypoxia-ischemia compared to sham controls. Furthermore, HIF-1α expression peaked at 8 h following hypoxia and hypoxia-ischemia, but at 24 h following ischemia alone. HIF-1α was distributed in important functional areas of the brains, such as the cortex and hippocampus.

Timing and pattern of HIF-1α up regulation varied by type of brain injury. The expression and distribution of HIF-1α following brain injury suggests that HIF-1α may be related to cellular repair.