正常孕妇及子痫前期患者血清抑制素A水平的研究

doi:10.3877/cma.j.issn.1673-5250.2005.02.107

目的

检测正常孕妇在各孕周血清抑制素A(Inhibin-A)的浓度，并探讨其与子痫前期发病的关系。

方法

采用酶联免疫吸附法(ELISA)检测691例正常孕妇及33例子痫前期孕妇外周血清中Inhibin-A的水平，统计分析子痫前期孕妇与正常孕妇血清Inhibin-A中位数的差异。

结果

正常孕妇Inhibin-A水平随孕周增加而逐渐升高，子痫前期孕妇血清Inhibin-A水平显著高于相同孕周正常孕妇的中位数。

结论

正常孕妇血清Inhibin-A浓度随妊娠进展逐渐增加，Inhibin-A浓度在子痫前期患者中明显升高。Inhibin-A升高对子痫前期发病有一定的指示作用。

关键词: 正常孕妇, 子痫前期, 抑制素-A

Objective

To detect the concentrations of serum Inhibin-A of pregnant women in eachgestational week, and to investigate the relationship between Inhibin-A level and the incidence of pre¬eclampsia.

Methods

Serum samples were obtained from 691 healthy pregnant women and 33 pre¬eclamptic pregnant women. Serum Inhibin-A was detected by ELISA. The difference of medians between normal pregnant women and pre-eclamptic pregnant women were compared.

Results

In normal maternal serum, the concentrations of serum Inhibin-A increased gradually with the process of pregnancy. The median of serum Inhibin-A levels of pre-eclamptic patients were significantly higher than that of normal pregnant women at the same gestational weeks.

Conclusion

The increase of serum Inhibin-A level is gradual with the process of pregnancy in normal pregnant women, while the serum Inhibin-A level rises significantly in pre-eclamptic pregnant patients. An elevated level of serum Inhibin-A may serve as a possible indicator for a higher risk of pre-eclampsia.

Key words: healthy pregnant women, pre-eclampsia, Inhibin-A

图1　正常孕妇与子痫前期孕妇Inhibin-A中位数分布图

	1　Florio P，Cobellis L, Lnisi S，et al. Changes in inhibins and active secretion in healthy and pathclogical pregnancies. Mol Cell Endocrinol, 2001, 180(1 ~ 2) ：123-130.
	2　杭爱国，陈晓残.唐氏综合征妊娠早期及中期筛查的进展.中华妇产科杂志，1998，33(5)：308.
	3　Keelan JA，Taylor R，Schellenberg JC，et al. Serum activin A，inhibin A and follistatin concentrations in pre-eclampsia or small for gestational age pregnancies. Obstet Gynecol，2002，99(2)：267-274.
	4　Yair D，Eshed-Englender T，Kupfermine MJ，et al. Serum activin B，unlike inhibin A and activin A，are not altered in women with preeclampsia. Am J Reprod Immunol, 2001，45(3) ：180-187.
	5　Hammer A, Dohr G. Apoptotic nuclei within the uterine deciduas of first trimester pregnancy arise fron CD45 positive leukocytes. Am J Reprod Immunol, 1999，42(2):88-94.
	6　Bersinger NA, Smarason AK, Muttukrishna S，et al. Women with pre-eclampsia have increased serum levels of pregnancy-associated plasma protein-A(PAPP-A)，inhibin A, activin A and soluble E-selectin. Hypertens Pregnancy, 2003，22(1) ：45-55.
	7　Jenkin G，Ward J，Hooper S，et al. Feto-placental hypoxemia regulates the release of fetal activin A and prostaglandin E (2). Endocrinology, 2001，142(2) ：963-966.

[1]	壮健, 潘昌杰, 李晓琴, 于梦霞, 张超, 朱韦文. 剪切波弹性成像技术评估子痫前期胎盘弹性的临床价值[J]. 中华医学超声杂志（电子版）, 2022, 19(07): 660-666.
[2]	刘夕珑, 荣茜, 邢悦, 潘碧琼, 卢丹. 血清氨基末端脑钠肽前体水平与重度子痫前期孕妇妊娠结局的关系[J]. 中华妇幼临床医学杂志(电子版), 2021, 17(06): 709-714.
[3]	鞠捷, 李济宇, 顾建娟, 刘立卓, 吕芳. 血清乳酸脱氢酶检测对子痫前期诊断价值的Meta分析[J]. 中华妇幼临床医学杂志(电子版), 2021, 17(05): 612-620.
[4]	韦先梅, 韩毓, 蒋英彩. 敲减circSERPINE2通过靶向调控miR-34a-5p表达抑制滋养层细胞增殖、迁移和侵袭[J]. 中华细胞与干细胞杂志(电子版), 2023, 13(04): 193-201.
[5]	何豆豆, 孙晓彤, 曲涛, 李忠媛, 杨雪萍. 间充质干细胞源性外泌体对子痫前期滋养层细胞生物学行为影响的研究进展[J]. 中华细胞与干细胞杂志(电子版), 2022, 12(05): 309-313.
[6]	刘莎莎, 孙国强, 吴利荣. 木犀草素对子痫前期大鼠滋养层细胞凋亡的影响及其机制[J]. 中华细胞与干细胞杂志(电子版), 2022, 12(03): 138-144.
[7]	宋海红, 黎娉, 陈鲜霞. 子宫动脉搏动指数、外周血胎儿血红蛋白及胎盘生长因子水平与早发型子痫前期再次妊娠结局的关系[J]. 中华临床医师杂志(电子版), 2022, 16(11): 1109-1114.
[8]	谢玲, 霍春霞, 张爱萍. sFlt-1、PLGF对孕妇子痫前期的诊断及预测价值[J]. 中华临床医师杂志(电子版), 2022, 16(09): 902-907.
[9]	祝淡抹, 刘雪琼, 卢丹. 母体外周血中炎性标志物与子痫前期的相关性分析[J]. 中华临床医师杂志(电子版), 2021, 15(11): 865-870.
[10]	郑晓芳, 魏宋荃, 黄真轩, 吴文诗, 李桂民, 张红霞, 江庆萍, 陈敦金, 余琳. 子痫前期合并胎儿生长受限的妊娠结局及胎盘病理改变的研究[J]. 中华产科急救电子杂志, 2023, 12(02): 85-92.
[11]	贺芳. 易栓症和子痫前期[J]. 中华产科急救电子杂志, 2023, 12(01): 6-11.
[12]	周燕媚, 孙雯, 林琳, 陈娟娟, 杜培丽, 张慧丽, 陈兢思, 杜丽丽, 陈敦金. 子痫前期并发心力衰竭的诊治和评估[J]. 中华产科急救电子杂志, 2022, 11(04): 228-233.
[13]	王鑫鑫, 樊尚荣. 重度子痫前期并发急性左心衰的诊断和处理[J]. 中华产科急救电子杂志, 2022, 11(02): 77-80.
[14]	杜培丽, 孙雯, 苏春宏, 张春芳, 余琳, 贺芳, 杜丽丽, 陈兢思, 陈敦金. 不同亚型子痫前期患者母儿结局分析[J]. 中华产科急救电子杂志, 2022, 11(01): 33-37.
[15]	董欣, 李雪兰. 硫酸镁治疗子痫前期过程中存在的问题与困惑[J]. 中华产科急救电子杂志, 2021, 10(04): 206-210.

阅读次数

全文

摘要

选择文件类型/文献管理软件名称

选择包含的内容

A study on the concentration of serum Inhibin-A in normal and pre-eclampsia pregnant women

模态框（Modal）标题

选择文件类型/文献管理软件名称

选择包含的内容

A study on the concentration of serum Inhibin-A in normal and pre-eclampsia pregnant women