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中华妇幼临床医学杂志(电子版) ›› 2025, Vol. 21 ›› Issue (04) : 482 -489. doi: 10.3877/cma.j.issn.1673-5250.2025.04.015

综述

小于胎龄儿围产期及预后研究进展
李明玉1, 邓杨欢1, 郑相贻1, 夏斌2,3,()   
  1. 1眉山市妇幼保健院新生儿科,眉山 620010
    2四川大学华西第二医院新生儿科、出生缺陷与相关妇儿疾病教育部重点实验室,成都 610041
    3四川大学华西第二医院天府医院·四川省儿童医院新生儿科,眉山 620010
  • 收稿日期:2025-06-05 修回日期:2025-07-09 出版日期:2025-08-01
  • 通信作者: 夏斌

Research progress on perinatal period and prognosis of small for gestational age infants

Mingyu Li1, Yanghuan Deng1, Xiangyi Zheng1, Bin Xia2,3,()   

  1. 1Department of Neonatology, Meishan Maternity and Child Health Hospital, Meishan 620010, Sichuan Province, China
    2Department of Neonatology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    3Department of Neonatology, WCSUH-Tianfu·Sichuan Provincial Children′s Hospital, Meishan 620010, Sichuan Province, China
  • Received:2025-06-05 Revised:2025-07-09 Published:2025-08-01
  • Corresponding author: Bin Xia
  • Supported by:
    National Natural Science Foundation of China(81370738)
引用本文:

李明玉, 邓杨欢, 郑相贻, 夏斌. 小于胎龄儿围产期及预后研究进展[J/OL]. 中华妇幼临床医学杂志(电子版), 2025, 21(04): 482-489.

Mingyu Li, Yanghuan Deng, Xiangyi Zheng, Bin Xia. Research progress on perinatal period and prognosis of small for gestational age infants[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2025, 21(04): 482-489.

目前世界对小于胎龄(SGA)儿发病率的文献报道尚不统一,为6.61%~12.28%。SGA儿相较于适于胎龄(AGA)儿有较高死亡率,以及较高围产期与远期并发症发生率。早期识别SGA儿相关危险因素及并发症,并及时干预,是改善其远期预后的关键。笔者拟对SGA儿流行病学研究现状,导致SGA儿发生的高危因素及预防,SGA儿围产期并发症与预后、SGA儿生后干预措施及改善预后的相关措施等3个方面的最新研究进展进行综述,旨在为临床对SGA儿诊治的进一步研究提供参考。

At present, the literature reports on the incidence of small for gestational age (SGA) infants in the world are not uniform, ranging from 6.61% to 12.28%. Compared with appropriate for gestational age (AGA) infants, SGA infants have higher mortality, and higher perinatal complications and long-term complications. Early identification of SGA infants related risk factors and complications, and timely intervention are the key to improve their long-term prognosis. The author intends to review the latest research progress in three aspects about epidemiological research status of SGA infants, high risk factors and prevention of SGA infants, perinatal complications and prognosis of SGA infants, and intervention measures for SGA infants after birth and related measures to improve prognosis, in order to provide reference for further clinical research on the diagnosis and treatment of SGA infants.

[1]
Hokken-Koelega ACS, van der Steen M, Boguszewski MCS, et al. International consensus guideline on small for gestational age: etiology and management from infancy to early adulthood[J]. Endocr Rev, 2023, 44(3): 539-565. DOI:10.1210/endrev/bnad002.
[2]
王庆红,杨于嘉,魏克伦,等. 我国小于胎龄儿现状分析[J]. 中国实用儿科杂志2009, 24(3): 177-180.
[3]
Lee AC, Katz J, Blencowe H, et al. National and regional estimates of term and preterm babies born small for gestational age in 138 low-income and middle-income countries in 2010[J]. Lancet Glob Health, 2013, 1(1): e26-e36.
[4]
Ota E, Ganchimeg T, Morisaki N, et al. Risk factors and adverse perinatal outcomes among term and preterm infants born small-for-gestational-age: secondary analyses of the WHO multi-country survey on maternal and newborn health[J]. PLoS One, 2014, 9(8): e105155. DOI: 10.1371/journal.pone.0105155.
[5]
Cho WK, Jung IA, Suh BK. Current growth status and metabolic parameters of Korean adolescents born small for gestational age: results from the Korea National Health and Nutrition Examination Surveys (KNHANES) 2010-2011[J]. Pediatr Int, 2014, 56(3): 344-348. DOI: 10.1111/ped.12278.
[6]
Kozuki N, Katz J, Christian P, et al. Comparison of US birth weight references and the International Fetal and Newborn Growth Consortium for the 21st century standard[J]. JAMA Pediatr, 2015, 169(7): e151438. DOI: 10.1001/jamapediatrics.2015.1438.
[7]
He H, Miao H, Liang Z, et al. Prevalence of small for gestational age infants in 21 cities in China, 2014-2019[J]. Sci Rep, 2021, 11(1): 7500. DOI: 10.1038/s41598-021-87127-9.
[8]
Zhou R, Yu H, Qian N, et al. Secular trends of low birth weight, preterm birth, and small for gestational age in Shanghai from 2004 to 2020: an age-period-cohort analysis[J]. BMC Pregnancy Childbirth, 2023, 23(1): 540. DOI: 10.1186/s12884-023-05799-9.
[9]
Lawn JE, Ohuma EO, Bradley E, et al. Small babies, big risks: global estimates of prevalence and mortality for vulnerable newborns to accelerate change and improve counting[J]. Lancet, 2023, 401(10389): 1707-1719. DOI: 10.1016/S0140-6736(23)00522-6.
[10]
王启闯,史俊君,杨斯岚,等. 小于胎龄儿的临床特征及早产小于胎龄儿高危因素分析[J]. 汕头大学医学院学报2022, 35(3): 136-140. DOI: 10.13401/j.cnki.jsumc.2022.03.002.
[11]
Silver RM. Examining the link between placental pathology, growth restriction, and stillbirth[J]. Best Pract Res Clin Obstet Gynaecol, 2018, 49: 89-102. DOI: 10.1016/j.bpobgyn.2018.03.004.
[12]
祝捷,马军. 小于胎龄儿的研究现况[J]. 中国新生儿科杂志2012, 27(1): 68-70. DOI: 10.3969/j.issn.1673-6710.2012.01.027.
[13]
Miremberg H, Grinstein E, Herman HG, et al. The association between isolated oligohydramnios at term and placental pathology in correlation with pregnancy outcomes[J]. Placenta, 2020, 90: 37-41. DOI:10.1016/j.placenta.2019.12.004.
[14]
Chiavaroli V, Castorani V, Guidone P, et al. Incidence of infants born small- and large-for-gestational-age in an Italian cohort over a 20-year period and associated risk factors[J]. Ital J Pediatr, 2016, 42(1): 42. DOI: 10.1186/s13052-016-0254-7.
[15]
Finken MJJ, van der Steen M, Smeets CCJ, et al. Children born small for gestational age: differential diagnosis, molecular genetic evaluation, and implications[J]. Endocr Rev, 2018, 39(6): 851-894. DOI: 10.1210/er.2018-00083.
[16]
Melamed N, Baschat A, Yinon Y, et al. FIGO (International Federation of Gynecology and Obstetrics) initiative on fetal growth: best practice advice for screening, diagnosis, and management of fetal growth restriction[J]. Int J Gynecol Obstet, 2021, 152(S1): 3-57. DOI: 10.1002/ijgo.13522.
[17]
黄林环,王子莲. 多胎妊娠的孕期监护[J]. 实用妇产科杂志2019, 35(9): 647-650.
[18]
Cao C, Cai W, Niu X, et al. Prehypertension during pregnancy and risk of small for gestational age: a systematic review and Meta-analysis[J]. J Matern Fetal Neonatal Med, 2018: 1-8. DOI: 10.1080/14767058.2018.1519015.
[19]
Yi SW, Han YJ, Ohrr H. Anemia before pregnancy and risk of preterm birth, low birth weight and small-for-gestational-age birth in Korean women[J]. Eur J Clin Nutr, 2013, 67(4): 337-342. DOI: 10.1038/ejcn.2013.12.
[20]
McGrath RT, Fulcher GR, Glastras SJ. Comment on Ooi and Wong. Twin pregnancy with gestational diabetes mellitus: a double whammy? Diabetes Care 2018;41: E15-E16[J]. Diabetes Care, 2018, 41(4): e67. DOI: 10.2337/dc17-2594.
[21]
Gutaj P, Wender-Ozegowska E. Diagnosis and management of IUGR in pregnancy complicated by type 1 diabetes mellitus[J]. Curr Diabetes Rep, 2016, 16(5): 39. DOI: 10.1007/s11892-016-0732-8.
[22]
林晓洁,王芳会,刘俐. 140例小于胎龄儿高危因素及并发症分析[J]. 中国妇幼健康研究2013, 24(1):49-52. DOI: 10.3969/j.issn.1673-5293.2013.01.018.
[23]
Osamor PE, Grady C. Women′s autonomy in health care decision-making in developing countries: a synthesis of the literature[J]. Int J Womens Health, 2016, 8: 191-202. DOI: 10.2147/ijwh.s105483.
[24]
Louw KA. Substance use in pregnancy: the medical challenge[J]. Obstet Med, 2018, 11(2): 54-66. DOI: 10.1177/1753495x17750299.
[25]
Poeran J, Maas AFG, Birnie E, et al. Social deprivation and adverse perinatal outcomes among Western and non-Western pregnant women in a Dutch urban population[J]. Soc Sci Med, 2013, 83: 42-49. DOI: 10.1016/j.socscimed.2013.02.008.
[26]
牛利美,李书书,韩树萍,等. 极早产儿中小于胎龄儿的影响因素与临床特征分析:多中心队列研究[J]. 中华围产医学杂志2024, 27(10): 793-801. DOI: 10.3760/cma.j.cn113903-20240510-00340.
[27]
张璐,杨惠娟,刘凯波. 2015—2021年北京市辅助生殖技术助孕活产及高龄孕母占比与不良妊娠结局变化趋势[J/OL]. 中华妇幼临床医学杂志(电子版), 2023, 19(1): 46-53. DOI: 10.3877/cma.j.issn.1673-5250.2023.01.007.
[28]
蒋晓东,包蕾. 小于胎龄儿发生新生儿呼吸窘迫综合征的危险因素分析[D]. 重庆:重庆医科大学,2021.
[29]
杨华,悦光,巨容. 小于胎龄的极低出生体重儿肠道血流特点及其对消化道并发症的影响[J]. 中国妇幼健康研究2022, 33(3): 41-46. DOI: 10.3969/j.issn.1673-5293.2022.03.007.
[30]
何洋,蔡丽梅,唐军,等. 晚期早产儿中小于胎龄儿和适于胎龄儿的临床特点分析[J/OL]. 中华妇幼临床医学杂志(电子版), 2017, 13(4): 461-465. DOI: 10.3877/cma.j.issn.1673-5250.2017.04.016.
[31]
Lee SM, Namgung R, Park MS, et al. Parenteral nutrition associated cholestasis is earlier, more prolonged and severe in small for gestational age compared with appropriate for gestational age very low birth weight infants[J]. Yonsei Med J, 2013, 54(4): 839-844. DOI: 10.3349/ymj.2013.54.4.839.
[32]
陈瑜,朱雪萍. 小于胎龄早产儿胆汁淤积症的临床特征及危险因素[J]. 中国当代儿科杂志2024, 26(10): 1027-1033. DOI: 10.7499/j.issn.1008-8830.2404095.
[33]
Kobayashi S, Sata F, Hanaoka T, et al. Association between maternal passive smoking and increased risk of delivering small-for-gestational-age infants at full-term using plasma cotinine levels from The Hokkaido Study: a prospective birth cohort[J]. BMJ Open, 2019, 9(2): e023200. DOI: 10.1136/bmjopen-2018-023200.
[34]
Tamai K, Yorifuji T, Takeuchi A, et al. Associations of birth weight for gestational age with child health and neurodevelopment among term infants: a nationwide Japanese population-based study[J]. J Pediatr, 2020, 226: 135-141.e4. DOI: 10.1016/j.jpeds.2020.06.075.
[35]
de Jong M, Cranendonk A, van Weissenbruch MM. Components of the metabolic syndrome in early childhood in very-low-birth-weight infants and term small and appropriate for gestational age infants[J]. Pediatr Res, 2015, 78(4): 457-461. DOI: 10.1038/pr.2015.118.
[36]
Sebastiani G, Díaz M, Bassols J, et al. The sequence of prenatal growth restraint and post-natal catch-up growth leads to a thicker intima-media and more pre-peritoneal and hepatic fat by age 3-6 years[J]. Pediatr Obes, 2016, 11(4): 251-257. DOI: 10.1111/ijpo.12053.
[37]
李力,邹仙,马娟,等. 昆士兰临床指南:小于胎龄新生儿指南解读[J]. 西部医学2022, 34(9): 1255-1259. DOI: 10.3969/j.issn.1672-3511.2022.09.002.
[38]
中国妇幼保健协会新生儿保健专业委员会,中国医师协会新生儿科医师分会. 产科母婴同室新生儿管理建议[J]. 中华新生儿科杂志(中英文), 2017, 32(2): 81-85. DOI:10.3760/cma.j.issn.2096-2932.2017.02.001.
[39]
郭立珍,范天群,张欣凯,等. 早产小于胎龄儿发生支气管肺发育不良的危险因素及预后分析[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(2): 209-215. DOI: 10.3877/cma.j.issn.1673-5250.2024.02.012.
[40]
张丽娇,李科兴,宋霞. 早产儿暂时性低甲状腺素血症影响因素分析[J]. 吉林医学2016, 37(4): 819-821. DOI: 10.3969/j.issn.1004-0412.2016.04.018.
[41]
张珈宁,侯新琳. 先天性甲状腺功能减退症:2020—2021年欧洲儿科内分泌学学会和欧洲内分泌学学会共识指南更新[J]. 中华新生儿科杂志2022, 37(3): 286-288. DOI: 10.3760/cma.j.issn.2096-2932.2022.03.026.
[42]
中国医师协会儿科医师分会儿童保健学组. NICU出院高危儿0~3岁生长发育随访管理技术的专家共识[J]. 中国儿童保健杂志2021, 29(8): 809-814. DOI: 10.11852/zgetbjzz2020-2035.
[43]
《中华儿科杂志》编辑委员会,中华医学会儿科学分会儿童保健学组,中华医学会儿科学分会新生儿学组. 早产、低出生体重儿出院后喂养建议[J]. 中华儿科杂志2016, 54(1): 6-12. DOI: 10.3760/cma.j.issn.0578-1310.2016.01.003.
[44]
中国优生优育协会婴幼儿发育专业委员会. 高危新生儿行为神经发育早期干预专家共识[J]. 中国儿童保健杂志2022, 30(3): 233-236. DOI: 10.11852/zgetbjzz2021-0625.
[45]
何梅,张鸿,鲜蓉华,等. 439例早产儿及足月小于胎龄儿眼底筛查结果及眼底疾病危险因素分析[J]. 中国中医眼科杂志2023, 33(2): 127-131. DOI: 10.13444/j.cnki.zgzyykzz.2023.02.006.
[46]
中华预防医学会儿童保健分会,中国疾病预防控制中心妇幼保健中心,中国妇幼保健协会高危儿童健康管理专委会. 高危儿规范化健康管理专家共识[J]. 中国儿童保健杂志2023, 31(6): 581-585, 622. DOI: 10.11852/zgetbjzz2023-0347.
[47]
张悦. 我国儿童保健工作中高危儿管理内涵和外延的探析[J]. 中国儿童保健杂志2019, 27(2): 123-125. DOI: 10.11852/zgetbjzz2018-1853.
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