切换至 "中华医学电子期刊资源库"

中华妇幼临床医学杂志(电子版) ›› 2025, Vol. 21 ›› Issue (01) : 15 -20. doi: 10.3877/cma.j.issn.1673-5250.2025.01.002

妇儿影像学研究专辑

多模态影像学新技术在儿童腹部常见恶性肿瘤中的研究现状
高梅娟1, 董素贞1,()   
  1. 1. 上海交通大学医学院附属上海儿童医学中心放射科,上海 200127
  • 收稿日期:2024-09-01 修回日期:2025-01-03 出版日期:2025-02-01
  • 通信作者: 董素贞
  • 基金资助:
    上海市人力资源和社会保障局与上海市科学技术委员会上海市浦江人才计划(2019PJD030)

Current research status of multimodal imaging in pediatric common abdominal malignant tumors

Meijuan Gao1, Suzhen Dong1,()   

  1. 1. Department of Radiology,Shanghai Children's Medical Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China
  • Received:2024-09-01 Revised:2025-01-03 Published:2025-02-01
  • Corresponding author: Suzhen Dong
引用本文:

高梅娟, 董素贞. 多模态影像学新技术在儿童腹部常见恶性肿瘤中的研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2025, 21(01): 15-20.

Meijuan Gao, Suzhen Dong. Current research status of multimodal imaging in pediatric common abdominal malignant tumors[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2025, 21(01): 15-20.

神经母细胞瘤(NB)、肾母细胞瘤(WT)和肝母细胞瘤(HB)是儿童最常见的腹部3大恶性肿瘤,早期准确诊断并进行明确的分期、分级,不仅有助于临床为患儿制定个性化的治疗方案,还有助于临床预测患儿预后。随着近年多模态影像学(multimodal imaging)新技术,如造影增强超声(CEUS)、能谱CT、磁共振扩散加权成像(DWI)、光学分子成像(OMI)等微观成像技术的不断发展,使得儿科腹部肿瘤的诊断、分期与分级及预后评估等越来越准确。笔者拟就多模态影像学新技术概述及其在儿童上述最常见的腹部3大恶性肿瘤诊断中应用的最新研究现状进行阐述。

Neuroblastoma(NB),Wilms tumor(WT)and hepatoblastoma(HB)are the most three common abdominal malignant tumors in children.Early diagnosis and accurate staging can not only help to develop personalized treatment plans,but also predict the prognosis of children.In recent years,the continuous development of multimodal imaging technologies such as contra-enhanced ultrasound (CEUS),energy spectrum CT,diffusion weighted imaging(DWI)and optical molecular imaging(OMI)have made the diagnosis,staging,grading,and prognosis evaluation of pediatric abdominal tumors increasingly accurate.The author intends to introduce the new multimodal imaging techniques and the latest research status of their application in the diagnosis of the above three most common abdominal malignancies in children.

[1]
Han D,Wang T,Wang R,et al.Application of quantitative parameters of contrast-enhanced ultrasound in common benign and malignant lesions in pediatric livers:a preliminary study[J].Diagnostics,2023,13(22):3433.DOI:10.3390/diagnostics13223443.
[2]
Barr RG,Wilson SR,Rubens D,et al.Update to the Society of Radiologists in Ultrasound Liver Elastography Consensus Statement[J].Radiology,2020,296(2):263-274.DOI:10.1148/radiol.2020192437.
[3]
蒲金赟,叶蕾,何永华,等.超声剪切波弹性成像技术无创性评价肾组织病理的探索性研究[J].中华肾脏病杂志,2023,39(8):587-594.DOI:10.3760/cma.j.cn441217-20221121-01137.Pu JY,Ye L,He YH,et al.Exploratory study on noninvasive evaluation of renal histopathology by ultrasonic shear wave elastography[J].China J Nephrol,2023,39(8):587-594.DOI:10.3760/cma.j.cn441217-20221121-01137.
[4]
Václav V,Tamara S,Martina K,et al.Central venous catheter cannulation in pediatric anesthesia and intensive care:a prospective observational trial[J].Children,2022,9(11):1611.DOI:10.3390/children9111611.
[5]
Siegel MJ,Ramirez-Giraldo JC.Dual-energy CT in children:imaging algorithms and clinical applications[J].Radiology,2019,291(2):286-297.DOI:10.1148/radiol.2019182289.
[6]
Cao J,Bache S,Schwartz FR,et al.Pediatric applications of photon-counting detector CT[J].AJR Am J Roentgenol,2023,220(4):580-589.DOI:10.2214/AJR.22.28391.
[7]
Mese I,Altintas Mese C,Demirsoy U,et al.Innovative advances in pediatric radiology:computed tomography reconstruction techniques,photon-counting detector computed tomography,and beyond[J].Pediatr Radiol,2024,54(1):1-11.DOI:10.1007/s00247-023-05823-2.
[8]
Niklas A,Soenke L,Ute F,et al.Quantitative diffusionweighted MRI of neuroblastoma[J].Cancers,2023,15(7):1940.DOI:10.3390/cancers15071940.
[9]
Schooler GR,Squires JH,Alazraki A,et al.Pediatric hepatoblastoma,hepatocellular carcinoma,and other hepatic neoplasms:consensus imaging recommendations from American College of Radiology Pediatric Liver Reporting and Data System (LI-RADS)working group[J].Radiology,2020,296(3):493-497.DOI:10.1148/radiol.2020200751.
[10]
Vasireddi AK,Leo ME,Squires JH.Magnetic resonance imaging of pediatric liver tumors[J].Pediatr Radiol,2022,52(2):177-188.DOI:10.1007/s00247-021-05058-z.
[11]
Pia Z,Elisabeth BV,Küfner RL,et al.Whole-body magnetic resonance imaging in children-how and why?A systematic review[J].Pediatr Radiol,2020,51(1):14-24.DOI:10.1007/s00247-020-04735-9.
[12]
Schäfer JF,Granata C,von Kalle T,et al.Whole-body magnetic resonance imaging in pediatric oncology -recommendations by the Oncology Task Force of the ESPR[J].Pediatr Radiol,2020,50(8):1162-1174.DOI:10.1007/s00247-020-04683-4
[13]
Caro-Domínguez P,Victoria T,Bueno Gomez M,et al.Magnetic resonance imaging of fetal abdominal pathology:a complementary tool to prenatal ultrasound[J].Pediatr Radiol,2023,53(9):1829-1841.DOI:10.1007/s00247-023-05655-0.
[14]
Samia A,Tytgat GAM,Bleeker G,et al.Nuclear medicine imaging in neuroblastoma:current status and new developments[J].J Pers Med,2021,11(4):270.DOI:10.3390/jpm11040270.
[15]
Jha SK,Brown C,Kang L,et al.Update on the role of imaging in staging of common pediatric abdominal tumors[J].Curr Probl Cancer,2023,47(2):100969.DOI:10.1016/j.currproblcancer.2023.100969.
[16]
Lai HA,Sharp SE,Bhatia A,et al.Imaging of pediatric neuroblastoma:a COG Diagnostic Imaging Committee/SPR Oncology C ommittee White Paper[J].Pediatr Blood Cancer,2023,70(Suppl 4):e29974.DOI:10.1002/pbc.29974.
[17]
Rees MA,Morin CE,Behr GG,et al.Imaging of pediatric adrenal tumors:A COG Diagnostic Imaging Committee/SPR Oncology C ommittee White Paper[J].Pediatr Blood Cancer,2023,70(Suppl 4):e29973.DOI:10.1002/pbc.29973.
[18]
Orr KE,Mc Hugh K.The new international neuroblastoma response criteria[J].Pediatric Radiol,2019,49(11):1433-1440.DOI:10.1007/s00247-019-04397-2.
[19]
Wang T,Han D,Xiao H,et al.A preliminary study on the application of contrast-enhanced ultrasonography in children with peripheral neuroblastic tumors[J].Ultrasound Med Biol,2024,50(6):954-960.DOI:10.1016/j.ultrasmedbio.2024.03.003.
[20]
Yang DD,Liu C,Gao J,et al.Association of image-defined risk factors with clinical features,tumor biology,and outcomes in neuroblastoma:a single-center retrospective study[J].Eur J Pediatr,2023,182(5):2189-2196.DOI:10.1007/s00431-023-04899-0.
[21]
Morin CE,Artunduaga M,Schooler GR,et al.Imaging for staging of pediatric abdominal tumors:an update,from the?AJR? special series on cancer staging[J].AJR Am J Roentgenol,2021,217(4):786-799.DOI:10.2214/AJR.20.25310.
[22]
Samim A,Tytgat GAM,Bleeker G,et al.Nuclear medicine imaging in neuroblastoma:current status and new developments[J].J Pers Med,2021,11(4):270.DOI:10.3390/jpm11040270.
[23]
Nakata K,Colombet M,Stiller CA,et al.Incidence of childhood renal tumours:an international population-based study[J].Int J Cancer,2020,147(12):3313-3327.DOI:10.1002/ijc.33147.
[24]
Artunduaga M,Eklund M,van der Beek JN,et al.Imaging of pediatric renal tumors:a COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper focused on Wilms tumor and nephrogenic rests[J].Pediatr Blood Cancer,2023,70(Suppl 4):e30004.DOI:10.1002/pbc.30004.
[25]
Hötker AM,Lollert A,Mazaheri Y,et al.Diffusionweighted MRI in the assessment of nephroblastoma:results of a multi-center trial[J].Abdom Radiol(NY),2020,45(10):3202-3212.DOI:10.1007/s00261-020-02475-w.
[26]
Fu Y,Zhong J,Tan Y,et al.Contrast-enhanced ultrasound for differentiating benign from malignant focal solid renal lesions in pediatric patients[J].Sci Rep,2024,14(1):11409.DOI:10.1038/s41598-024-62496-z.
[27]
van der Beek JN,Artunduaga M,Schenk JP,et al.Similarities and controversies in imaging of pediatric renal tumors:a SIOP-RTSG and COG collaboration[J].Pediatr Blood Cancer,2023,70(Suppl 2):e30080.DOI:10.1002/pbc.30080.
[28]
Watson T,Oostveen M,Rogers H ,et al.The role of imaging in the initial investigation of paediatric renal tumours[J].Lancet Child Adolesc Health,2020,4(3):232-241.DOI:10.1016/S2352-4642(19)30340-2.
[29]
Kahla JA,Siegel DA,Dai S,et al.Incidence and 5-year survival of children and adolescents with hepatoblastoma in the United States[J].Pediatr Blood Cancer,2022,69(10):e29763.DOI:10.1002/pbc.29763.
[30]
Schooler GR,Infante JC,Acord M,et al.Imaging of pediatric liver tumors:a COG diagnostic imaging committee/spr oncology committee white paper[J].Pediatr Blood Cancer,2023,70(Suppl 4):e29965.DOI:10.1002/pbc.29965.
[31]
Fang C,Anupindi SA,Back SJ,et al.Contrast-enhanced ultrasound of benign and malignant liver lesions in children[J].Pediatr Radiol,2021,51(12):2181-2197.DOI:10.1007/s00247-021-04976-2.
[1] 石珍, 杨小红, 赵胜, 伍玉晗, 王玉波, 陈诺. 先天性囊性神经母细胞瘤的产前及产后超声表现[J/OL]. 中华医学超声杂志(电子版), 2025, 22(01): 25-30.
[2] 余成军, 张杰, 裴军, 孔繁森, 杨舒媛, 吴盛德, 刘星, 温晟, 华燚, 魏光辉. 终末期肾病儿童肾移植临床特征和疗效分析[J/OL]. 中华移植杂志(电子版), 2025, 19(01): 31-35.
[3] 孙瑜博, 陈瑞, 翟亦晖, 汤梁峰, 张致庆, 王春燕, 耿红全, 沈茜, 刘锋, 徐虹. 合并膀胱功能障碍儿童肾移植受者疗效评估[J/OL]. 中华移植杂志(电子版), 2025, 19(01): 2-8.
[4] 姜梦婕, 黄淑娟, 裴瑜馨, 容丽萍, 许园园, 林知朗, 丘原全, 刘龙山, 蒋小云, 陈丽植. 儿童复发性移植肾肾病临床特点及诊治[J/OL]. 中华移植杂志(电子版), 2025, 19(01): 16-21.
[5] 曾锦华, 韩新利, 徐虹, 翟亦晖, 刘锋, 陈瑞, 方晓燕, 张致庆, 王春燕, 陈径, 沈茜. 儿童肾移植受者移植后淋巴组织增生性疾病临床特点及诊治[J/OL]. 中华移植杂志(电子版), 2025, 19(01): 22-25.
[6] 金小艳, 邓芳, 方韶晗, 丁亚婷. 儿童肾移植受者心脏结构及功能分析[J/OL]. 中华移植杂志(电子版), 2025, 19(01): 26-30.
[7] 孙淼, 吴盛德. 机器人辅助手术治疗小儿肾积水的范围综述[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2025, 19(01): 95-102.
[8] 刘志新, 陈小林, 肖文军, 刘思琪. 日间手术在儿童鞘膜积液腹腔镜手术中的应用[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2025, 19(01): 36-40.
[9] 范利杰, 韦雅丽. 右旋氯胺酮与舒芬太尼对腹腔镜疝囊高位结扎术患儿血流动力学及自主恢复的影响[J/OL]. 中华疝和腹壁外科杂志(电子版), 2025, 19(02): 214-218.
[10] 吕奎林, 陈虹. 465 例儿童肺炎支原体肺炎的流行病学及临床特征分析:一项单中心回顾性研究[J/OL]. 中华肺部疾病杂志(电子版), 2025, 18(01): 55-61.
[11] 鲍文海, 阮勤, 李菲菲. Th17/Treg 免疫失衡在儿童腹型过敏性紫癜诊断与病情评估中的应用[J/OL]. 中华消化病与影像杂志(电子版), 2025, 15(02): 162-167.
[12] 韩彩云, 马娇, 李燕. 血清PAF和sTM水平与小儿轮状病毒肠炎及脱水程度的相关性研究[J/OL]. 中华消化病与影像杂志(电子版), 2025, 15(01): 83-88.
[13] 王云, 刘磊, 徐敏, 怀德. 度普利尤单抗注射液加玉屏风颗粒治疗儿童中重度特应性皮炎的临床研究[J/OL]. 中华临床医师杂志(电子版), 2025, 19(01): 27-32.
[14] 魏庆, 刘静, 方育, 陈峋, 李燕. 儿童声带反常运动五例临床特征分析[J/OL]. 中华临床医师杂志(电子版), 2024, 18(12): 1161-1164.
[15] 吴荣昌, 房孝莲, 杨磊, 张诚玥, 赵军阳, 彭芸, 尤佳, 阴捷. 视网膜母细胞瘤动脉灌注化疗的并发症单中心研究分析[J/OL]. 中华介入放射学电子杂志, 2025, 13(01): 49-53.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?