巨噬细胞在儿童肺炎支原体肺炎中作用机制的研究现状

doi:10.3877/cma.j.issn.1673-5250.2023.06.004

中华妇幼临床医学杂志(电子版) ›› 2023, Vol. 19 ›› Issue (06) : 643 -648. doi: 10.3877/cma.j.issn.1673-5250.2023.06.004

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巨噬细胞在儿童肺炎支原体肺炎中作用机制的研究现状

薛嘉怡¹, 王丽¹, 艾涛¹^,^†(

)

^1. 电子科技大学医学院附属妇女儿童医院·成都市妇女儿童中心医院儿童呼吸科，成都　611731

收稿日期:2023-07-11 修回日期:2023-11-03 出版日期:2023-12-01
通信作者: 艾涛

Current research progress on mechanism of macrophages in children with Mycoplasma pneumoniae pneumonia

Jiayi Xue¹, Li Wang¹, Tao Ai¹^,^†()

^1. Department of Pediatric Respiratory Medicine, Chengdu Women′s and Children′s Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 611731, Sichuan Province, China

Received:2023-07-11 Revised:2023-11-03 Published:2023-12-01
Corresponding author: Tao Ai
Supported by:
Natural Science Foundation of Science and Technology Department of Sichuan Province(23NSFSC5420)

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肺炎支原体(MP)是儿童及青少年社区获得性肺炎中感染的主要病原体之一，容易引起MP肺炎(MPP)患儿全身多脏器功能损害，严重者危及其生命。巨噬细胞作为固有免疫系统中重要组成部分，在对MP识别、诱导免疫反应、清除病原体及炎症反应等方面发挥重要作用。笔者拟就巨噬细胞对MP的识别、吞噬，儿童感染MP后，巨噬细胞极化、逃避巨噬细胞杀伤与巨噬细胞凋亡、焦亡及自噬等的最新研究进展进行阐述，旨在为巨噬细胞在MPP患儿发病机制中的作用及对MPP患儿的临床诊治提供参考。

关键词: 支原体，肺炎, 巨噬细胞, 趋化因子类, 肺炎支原体肺炎, 儿童

Mycoplasma pneumoniae (MP) is one of the major pathogens of community-acquired pneumonia in children and adolescents. It can easily cause systemic multifunctional organ damage and endanger the life of severe MP pneumonia (MPP) child. As an important part of the innate immune system, macrophages play an important role in the recognition of MP, induction of immune response, elimination of pathogens and induction of inflammatory response. The authors will summarize the latest research progress on macrophage recognition and phagocytosis of MP, macrophage polarization, evasion of macrophage killing, macrophage apoptosis, pyroptosis and autophagy after children infected with MP, in order to provide references for the role of macrophages in the pathogenesis of children with MPP and the diagnosis and treatment of MP infection.

Key words: Mycoplasma pneumoniae, Macrophages, Chemotactic factors, Mycoplasma pneumoniae pneumonia, Child

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Current research progress on mechanism of macrophages in children with Mycoplasma pneumoniae pneumonia

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