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中华妇幼临床医学杂志(电子版) ›› 2022, Vol. 18 ›› Issue (03) : 255 -261. doi: 10.3877/cma.j.issn.1673-5250.2022.03.002

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富血小板血浆在妇科疾病治疗中应用及其研究现状
徐瑞涓1, 林渝2, 谭世桥1,†()   
  1. 1四川大学华西第二医院妇产科、生殖内分泌和生殖调控研究室、出生缺陷与相关妇儿疾病教育部重点实验室，成都　610041
    2四川大学华西第二医院手术室，成都　610041
  • 收稿日期:2021-09-30 修回日期:2022-04-30 出版日期:2022-06-01
  • 通信作者: 谭世桥

Application and research status of platelet-rich plasma in gynecological diseases

Ruijuan Xu1, Yu Lin2, Shiqiao Tan1,†()   

  1. 1Department of Obstetrics and Gynecology, Laboratory of Reproductive Endocrine and Reproductive Regulation, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    2Department of Operating Room, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2021-09-30 Revised:2022-04-30 Published:2022-06-01
  • Corresponding author: Shiqiao Tan
  • Supported by:
    Key Research Project of Science and Technology Department of Sichuan Province(2020YFS0074)
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徐瑞涓, 林渝, 谭世桥. 富血小板血浆在妇科疾病治疗中应用及其研究现状[J]. 中华妇幼临床医学杂志(电子版), 2022, 18(03): 255-261.

Ruijuan Xu, Yu Lin, Shiqiao Tan. Application and research status of platelet-rich plasma in gynecological diseases[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2022, 18(03): 255-261.

富血小板血浆(PRP)是人自体全血经离心后获得的血小板浓缩物，含有大量生长因子及蛋白质。PRP因其有助于组织再生、伤口愈合、瘢痕修复等作用，在骨科、皮肤科、口腔颌面外科、整形美容科等领域应用广泛，而在妇科领域应用迄今相对较少。最新研究结果显示，PRP具有促进子宫内膜和卵泡生长作用，在治疗薄型子宫内膜(TE)、改善子宫内膜容受性(ER)、恢复卵巢功能等方面取得较大进展，并为多种妇科疾病治疗提供新的研究方向和手段。笔者拟就PRP的制备及分类、在妇科疾病治疗中的应用及其前景展望等最新研究现状进行阐述。

关键词: 富血小板血浆, 血小板输注, 生物因子, 子宫内膜, 卵巢功能, 子宫内膜容受性, 宫腔黏连, 伤口愈合, 女(雌)性

Platelet-rich plasma (PRP) is a kind of platelet concentrate obtained from whole blood after centrifugation, with amount of growth factors and protein. PRP is widely used in orthopedics, dermatology, oral and maxillofacial surgery, plastic surgery and cosmetology, because of its functions in tissue regeneration, wound healing and scar repair, but PRP is less used in gynecology up to now. Recent studies have shown that PRP can promote growth of endometrium and folliculogenesis. Great progresses had been made in treatment of thin endometrium (TE), improvement of endometrial receptivity (ER) and restoration of ovarian function. PRP has provided new research direction and therapeutic means for many gynecological diseases. The author intends to elaborate on preparation and classification, and current status of clinical application of PRP in gynecological diseases.

Key words: Platelet-rich plasma, Platelet transfusion, Biological factors, Endometrium, Ovarian function, Endometrial receptivity, Intrauterine adhesions, Wound healing, Female
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