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中华妇幼临床医学杂志(电子版) ›› 2021, Vol. 17 ›› Issue (05) : 497 -502. doi: 10.3877/cma.j.issn.1673-5250.2021.05.001

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维生素D及其类似物对肾脏病患儿的保护作用
尚慧, 陶于洪†()   
  • 收稿日期:2021-05-01 修回日期:2021-09-11 出版日期:2021-10-01
  • 通信作者: 陶于洪

Protection effects of vitamin D and its analogues on children with pediatric kidney diseases

Hui Shang, Yuhong Tao†()   

  • Received:2021-05-01 Revised:2021-09-11 Published:2021-10-01
  • Corresponding author: Yuhong Tao
  • Supported by:
    Applied Basic Research Project of Science & Technology Department of Sichuan Province(2017JY0076)
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尚慧, 陶于洪. 维生素D及其类似物对肾脏病患儿的保护作用[J]. 中华妇幼临床医学杂志(电子版), 2021, 17(05): 497-502.

Hui Shang, Yuhong Tao. Protection effects of vitamin D and its analogues on children with pediatric kidney diseases[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2021, 17(05): 497-502.

维生素D是脂溶性维生素，通过其活性形式作用于维生素D受体(VDR)发挥作用。除了调节钙、磷代谢外，维生素D还具有免疫调节、抑制炎症、调节细胞生长分化、促进骨骼生长、抑制肿瘤细胞增殖等多种作用。肾脏病患儿普遍存在维生素D不足。笔者拟就维生素D及其类似物的分类，对肾脏病患儿的肾脏保护作用机制，如合理补充维生素D及其类似物可以通过抑制肾素-血管紧张素-醛固酮系统(RAAS)活性、保护足细胞、降低蛋白尿水平、缓解肾脏炎症、延缓肾脏纤维化和预防心血管疾病等多种机制，对肾脏病患儿肾脏发挥保护作用等进行阐述。

关键词: 维生素D, 维生素D类似物, 肾疾病, 肾小球肾炎, 肾病综合征, 狼疮肾炎, 慢性肾脏病, 肾脏保护, 儿童

Vitamin D is a fat-soluble vitamin, which plays a role through its active forms acting on vitamin D receptor (VDR). In addition to the role of regulating calcium and phosphorus metabolism, vitamin D also has various nonclassical effects, such as immunoregulation, inhibiting inflammation, regulating cell growth and differentiation, promoting bone growth, anti-tumor cell proliferation and so on. Vitamin D deficiency is common in children with kidney disease. This paper intends to focus on the classification of vitamin D and its analogues, and their mechanisms of protecting pediatric kidney diseases, including inhibiting activity of renin-angiotensin-aldosterone system (RAAS), protecting podocytes, reducing proteinuria, relieving renal inflammation, delaying renal fibrosis, preventing cardiovascular diseases, and so on.

Key words: Vitamin D, Vitamin D analogues, Kidney diseases, Glomerulonephritis, Nephrotic syndrome, Lupus nephritis, Chronic kidney disease, Renal protection, Child
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