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中华妇幼临床医学杂志(电子版) ›› 2021, Vol. 17 ›› Issue (03) : 368 -372. doi: 10.3877/cma.j.issn.1673-5250.2021.03.020

综述

高氧诱导肺血管内皮细胞损伤与支气管肺发育不良的研究进展
王思思, 伍金林†()   
  • 收稿日期:2020-06-21 修回日期:2021-05-14 出版日期:2021-06-01
  • 通信作者: 伍金林

Research progresses of hyperoxia-induced injury of pulmonary vascular endothelial cells in bronchopulmonary dysplasia

Sisi Wang, Jinlin Wu†()   

  • Received:2020-06-21 Revised:2021-05-14 Published:2021-06-01
  • Corresponding author: Jinlin Wu
  • Supported by:
    Applied Basic Research Project of Science & Technology Department of Sichuan Province(2021YJ0211); Popularization Application Project of Health Commission of Sichuan Province(20PJ070)
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王思思, 伍金林. 高氧诱导肺血管内皮细胞损伤与支气管肺发育不良的研究进展[J]. 中华妇幼临床医学杂志(电子版), 2021, 17(03): 368-372.

Sisi Wang, Jinlin Wu. Research progresses of hyperoxia-induced injury of pulmonary vascular endothelial cells in bronchopulmonary dysplasia[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2021, 17(03): 368-372.

支气管肺发育不良(BPD)常见于需要氧疗的早产儿，而高氧应激反应的主要靶细胞为肺血管内皮细胞(PVEC)。笔者拟就高氧对PVEC的生理功能、代谢过程及PVEC内信号分子改变，在BPD发生、发展中作用的研究进展进行综述。

关键词: 支气管肺发育不良, 肺, 内皮细胞, 血管重构, 高氧症, 病因学, 婴儿，早产

Bronchopulmonary dysplasia (BPD) is common in preterm infants who need oxygen therapy, and pulmonary vascular endothelial cells (PVEC) are the main target cells of hyperoxia stress response.This review focuses on the research progresses of physiological function, metabolic process and signal molecule changes of PVEC induced by hyperoxia in occurrence and development of BPD.

Key words: Bronchopulmonary dysplasia, Lung, Endothelial cells, Vascular remodeling, Hyperoxia, Etiology, Infant, premature
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