| [1] |
Fitzgibbons SC, Ching Y, Yu D, et al. Mortality of necrotizing enterocolitis expressed by birth weight categories[J]. J Pediatr Surg, 2009, 44(6): 1072-1075; discussion 1075-1076. DOI: 10.1016/j.jpedsurg.2009.02.013. |
| [2] |
Adams-Chapman I. Necrotizing enterocolitis and neurodevelopmental outcome[J]. Clin Perinatol, 2018, 45(3): 453-466. DOI: 10.1016/j.clp.2018.05.014. |
| [3] |
Müller MJ, Paul T, Seeliger S. Necrotizing enterocolitis in premature infants and newborns[J]. J Neonatal Perinatal Med, 2016, 9(3): 233-242. DOI: 10.3233/NPM-16915130. |
| [4] |
Battersby C, Santhalingam T, Costeloe K, et al. Incidence of neonatal necrotising enterocolitis in high-income countries: a systematic review[J]. Arch Dis Child Fetal Neonatal Ed, 2018, 103(2): F182, F189. DOI: 10.1136/archdischild-2017-313880. |
| [5] |
Battersby C, Longford N, Mandalia S, et al. Incidence and enteral feed antecedents of severe neonatal necrotising enterocolitis across neonatal networks in England, 2012-13: a whole-population surveillance study[J]. Lancet Gastroenterol Hepatol, 2017, 2(1): 43-51. DOI: 10.1016/S2468-1253(16)30117-0. |
| [6] |
Niño DF, Sodhi CP, Hackam DJ. Necrotizing enterocolitis: new insights into pathogenesis and mechanisms[J]. Nat Rev Gastroenterol Hepatol, 2016, 13(10): 590-600. DOI: 10.1038/nrgastro.2016.119. |
| [7] |
Eaton S, Rees CM, Hall NJ. Current research on the epidemiology, pathogenesis, and management of necrotizing enterocolitis[J]. Neonatology, 2017, 111(4): 423-430. DOI: 10.1159/000458462. |
| [8] |
Arthur CM, Nalbant D, Feldman HA, et al. Anemia induces gut inflammation and injury in an animal model of preterm infants[J]. Transfusion, 2019, 59(4): 1233-1245. DOI: 10.1111/trf.15254. |
| [9] |
Been JV, Lievense S, Zimmermann LJ, et al. Chorioamnionitis as a risk factor for necrotizing enterocolitis: a systematic review and Meta-analysis[J]. J Pediatr, 2013, 162(2): 236-242.e2. DOI: 10.1016/j.jpeds.2012.07.012. |
| [10] |
Lu Q, Cheng S, Zhou M, et al. Risk factors for necrotizing enterocolitis in neonates: a retrospective case-control study[J]. Pediatr Neonatol, 2017, 58(2): 165-170. DOI: 10.1016/j.pedneo.2016.04.002. |
| [11] |
Downard CD, Grant SN, Maki AC, et al. Maternal cigarette smoking and the development of necrotizing enterocolitis[J]. Pediatrics, 2012, 130(1): 78-82. DOI: 10.1542/peds.2011-3808. |
| [12] |
Alganabi M, Lee C, Bindi E, et al. Recent advances in understanding necrotizing enterocolitis[J]. F1000Res, 2019, 8: F1000 Faculty Rev-107. DOI: 10.12688/f1000research.17228.1. |
| [13] |
Sampath V, Menden H, Helbling D, et al. SIGIRR genetic variants in premature infants with necrotizing enterocolitis[J]. Pediatrics, 2015, 135(6): e1530-e1534. DOI: 10.1542/peds.2014-3386. |
| [14] |
Kimak KS, de Castro Antunes MM, Braga TD, et al. Influence of enteral nutrition on occurrences of necrotizing enterocolitis in very-low-birth-weight infants[J]. J Pediatr Gastroenterol Nutr, 2015, 61(4): 445-450. DOI: 10.1097/MPG.0000000000000835. |
| [15] |
Stoll BJ, Hansen NI, Bell EF, et al. Trends in care practices, morbidity, and mortality of extremely preterm neonates, 1993-2012[J]. JAMA, 2015, 314(10): 1039-1051. DOI: 10.1001/jama.2015.10244. |
| [16] |
Burge K, Bergner E, Gunasekaran A, et al. The role of glycosaminoglycans in protection from neonatal necrotizing enterocolitis: a narrative review[J]. Nutrients, 2020, 12(2): 546. DOI: 10.3390/nu12020546. |
| [17] |
Warner BB, Deych E, Zhou Y, et al. Gut bacteria dysbiosis and necrotising enterocolitis in very low birthweight infants: a prospective case-control study[J]. Lancet, 2016, 387(10031): 1928-1936. DOI: 10.1016/S0140-6736(16)00081-7. |
| [18] |
Vongbhavit K, Underwood MA. Prevention of necrotizing enterocolitis through manipulation of the intestinal microbiota of the premature infant[J]. Clin Ther, 2016, 38(4): 716-732. DOI: 10.1016/j.clinthera.2016.01.006. |
| [19] |
Hackam DJ, Good M, Sodhi CP. Mechanisms of gut barrier failure in the pathogenesis of necrotizing enterocolitis: Toll-like receptors throw the switch[J]. Semin Pediatr Surg, 2013, 22(2): 76-82. DOI: 10.1053/j.sempedsurg.2013.01.003. |
| [20] |
Mihi B, Good M. Impact of toll-like receptor 4 signaling in necrotizing enterocolitis: the state of the science[J]. Clin Perinatol, 2019, 46(1): 145-157. DOI: 10.1016/j.clp.2018.09.007. |
| [21] |
Sodhi CP, Shi XH, Richardson WM, et al. Toll-like receptor-4 inhibits enterocyte proliferation via impaired beta-catenin signaling in necrotizing enterocolitis[J]. Gastroenterology, 2010, 138(1): 185-196. DOI: 10.1053/j.gastro.2009.09.045. |
| [22] |
Maheshwari A, Kelly DR, Nicola T, et al. TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine[J]. Gastroenterology, 2011, 140(1): 242-253. DOI: 10.1053/j.gastro.2010.09.043. |
| [23] |
Smythies LE, Sellers M, Clements RH, et al. Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity[J]. J Clin Invest, 2005, 115(1): 66-75. DOI: 10.1172/JCI19229. |
| [24] |
Mara MA, Good M, Weitkamp JH. Innate and adaptive immunity in necrotizing enterocolitis[J]. Semin Fetal Neonatal Med, 2018, 23(6): 394-399. DOI: 10.1016/j.siny.2018.08.002. |
| [25] |
Shah PS, Shah VS, Kelly LE. Arginine supplementation for prevention of necrotising enterocolitis in preterm infants[J]. Cochrane Database Syst Rev, 2017, 4: CD004339. DOI: 10.1002/14651858.CD004339.pub4. |
| [26] |
Robinson JL, Smith VA, Stoll B, et al. Prematurity reduces citrulline-arginine-nitric oxide production and precedes the onset of necrotizing enterocolitis in piglets[J]. Am J Physiol Gastrointest Liver Physiol, 2018, 315(4): G638, G649. DOI: 10.1152/ajpgi.00198.2018. |
| [27] |
Egan CE, Sodhi CP, Good M, et al. Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis[J]. J Clin Invest, 2016, 126(2): 495-508. DOI: 10.1172/JCI83356. |
| [28] |
Shulhan J, Dicken B, Hartling L, et al. Current knowledge of necrotizing enterocolitis in preterm infants and the impact of different types of enteral nutrition products[J]. Adv Nutr, 2017, 8(1): 80-91. DOI: 10.3945/an.116.013193. |
| [29] |
Collado MC, Rautava S, Aakko J, et al. Human gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid[J]. Sci Rep, 2016, 6: 23129. DOI: 10.1038/srep23129. |
| [30] |
Denning NL, Prince JM. Neonatal intestinal dysbiosis in necrotizing enterocolitis[J]. Mol Med, 2018, 24(1): 4. DOI: 10.1186/s10020-018-0002-0. |
| [31] |
La Rosa PS, Warner BB, Zhou Y, et al. Patterned progression of bacterial populations in the premature infant gut[J]. Proc Natl Acad Sci USA, 2014, 111(34): 12522-12527. DOI: 10.1073/pnas.1409497111. |
| [32] |
Underwood MA, Sohn K. The microbiota of the extremely preterm infant[J]. Clin Perinatol, 2017, 44(2): 407-427. DOI: 10.1016/j.clp.2017.01.005. |
| [33] |
Jacquot A, Neveu D, Aujoulat F, et al. Dynamics and clinical evolution of bacterial gut microflora in extremely premature patients[J]. J Pediatr, 2011, 158(3): 390-396. DOI: 10.1016/j.jpeds.2010.09.007. |
| [34] |
Arboleya S, Sánchez B, Milani C, et al. Intestinal microbiota development in preterm neonates and effect of perinatal antibiotics[J]. J Pediatr, 2015, 166(3): 538-544. DOI: 10.1016/j.jpeds.2014.09.041. |
| [35] |
Sim K, Shaw AG, Randell P, et al. Dysbiosis anticipating necrotizing enterocolitis in very premature infants[J]. Clin Infect Dis, 2015, 60(3): 389-397. DOI: 10.1093/cid/ciu822. |
| [36] |
Mai V, Young CM, Ukhanova M, et al. Fecal microbiota in premature infants prior to necrotizing enterocolitis[J]. PLoS One, 2011, 6(6): e20647. DOI: 10.1371/journal.pone.0020647. |
| [37] |
Morrow AL, Lagomarcino AJ, Schibler KR, et al. Early microbial and metabolomic signatures predict later onset of necrotizing enterocolitis in preterm infants[J]. Microbiome, 2013, 1(1): 13. DOI: 10.1186/2049-2618-1-13. |
| [38] |
Gopalakrishna KP, Macadangdang BR, Rogers MB, et al. Maternal IgA protects against the development of necrotizing enterocolitis in preterm infants[J]. Nat Med, 2019, 25(7): 1110-1115. DOI: 10.1038/s41591-019-0480-9. |
| [39] |
Heida FH, van Zoonen A, Hulscher J, et al. A necrotizing enterocolitis-associated gut microbiota is present in the meconium: results of a prospective study[J]. Clin Infect Dis, 2016, 62(7): 863-870. DOI: 10.1093/cid/ciw016. |
| [40] |
Brower-Sinning R, Zhong D, Good M, et al. Mucosa-associated bacterial diversity in necrotizing enterocolitis[J]. PLoS One, 2014, 9(9): e105046. DOI: 10.1371/journal.pone.0105046. |
| [41] |
Tanner SM, Berryhill TF, Ellenburg JL, et al. Pathogenesis of necrotizing enterocolitis: modeling the innate immune response[J]. Am J Pathol, 2015, 185(1): 4-16. DOI: 10.1016/j.ajpath.2014.08.028. |
| [42] |
Hodzic Z, Bolock AM, Good M. The role of mucosal immunity in the pathogenesis of necrotizing enterocolitis[J]. Front Pediatr, 2017, 5: 40. DOI: 10.3389/fped.2017.00040. |
| [43] |
Zhou W, Li W, Zheng XH, et al. Glutamine downregulates TLR-2 and TLR-4 expression and protects intestinal tract in preterm neonatal rats with necrotizing enterocolitis[J]. J Pediatr Surg, 2014, 49(7): 1057-1063. DOI: 10.1016/j.jpedsurg.2014.02.078. |
| [44] |
Cario E. Barrier-protective function of intestinal epithelial Toll-like receptor 2[J]. Mucosal Immunol, 2008, 1(Suppl 1): S62-S66. DOI: 10.1038/mi.2008.47. |
| [45] |
Ford H, Watkins S, Reblock K, et al. The role of inflammatory cytokines and nitric oxide in the pathogenesis of necrotizing enterocolitis[J]. J Pediatr Surg, 1997, 32(2): 275-282. DOI: 10.1016/s0022-3468(97)90194-9. |
| [46] |
Aceti A, Beghetti I, Martini S, et al. Oxidative stress and necrotizing enterocolitis: pathogenetic mechanisms, opportunities for intervention, and role of human milk[J]. Oxid Med Cell Longev, 2018, 2018: 7397659. DOI: 10.1155/2018/7397659. |
| [47] |
Maheshwari A, Patel RM, Christensen RD. Anemia, red blood cell transfusions, and necrotizing enterocolitis[J]. Semin Pediatr Surg, 2018, 27(1): 47-51. DOI: 10.1053/j.sempedsurg.2017.11.009. |
| [48] |
Teišerskas J, Bartašienė R, Tamelienė R. Associations between red blood cell transfusions and necrotizing enterocolitis in very low birth weight infants: ten-year data of a tertiary neonatal unit[J]. Medicina (Kaunas), 2019, 55(1): 16. DOI: 10.3390/medicina55010016. |
| [49] |
Managlia E, Liu S, Yan X, et al. Blocking NF-κB activation in Ly6c ＋ monocytes attenuates necrotizing enterocolitis[J]. Am J Pathol, 2019, 189(3): 604-618. DOI: 10.1016/j.ajpath.2018.11.015. |
| [50] |
MohanKumar K, Namachivayam K, Song T, et al. A murine neonatal model of necrotizing enterocolitis caused by anemia and red blood cell transfusions[J]. Nat Commun, 2019, 10(1): 3494. DOI: 10.1038/s41467-019-11199-5. |
| [51] |
Good M, Sodhi CP, Egan CE, et al. Breast milk protects against the development of necrotizing enterocolitis through inhibition of Toll-like receptor 4 in the intestinal epithelium via activation of the epidermal growth factor receptor[J]. Mucosal Immunol, 2015, 8(5): 1166-1179. DOI: 10.1038/mi.2015.30. |
| [52] |
|
| [53] |
Sullivan S, Schanler RJ, Kim JH, et al. An exclusively human milk-based diet is associated with a lower rate of necrotizing enterocolitis than a diet of human milk and bovine milk-based products[J]. J Pediatr, 2010, 156(4): 562-567.e1. DOI: 10.1016/j.jpeds.2009.10.040. |
| [54] |
Nolan LS, Parks OB, Good M. A review of the immunomodulating components of maternal breast milk and protection against necrotizing enterocolitis[J]. Nutrients, 2019, 12(1): 14. DOI: 10.3390/nu12010014. |
| [55] |
Garrido D, Ruiz-Moyano S, Kirmiz N, et al. A novel gene cluster allows preferential utilization of fucosylated milk oligosaccharides in Bifidobacterium longum subsp. longum SC596[J]. Sci Rep, 2016, 6: 35045. DOI: 10.1038/srep35045. |
| [56] |
Wang C, Zhang M, Guo H, et al. Human milk oligosaccharides protect against necrotizing enterocolitis by inhibiting intestinal damage via increasing the proliferation of crypt cells[J]. Mol Nutr Food Res, 2019, 63(18): e1900262. DOI: 10.1002/mnfr.201900262. |
| [57] |
Good M, Sodhi CP, Yamaguchi Y, et al. The human milk oligosaccharide 2′-fucosyllactose attenuates the severity of experimental necrotising enterocolitis by enhancing mesenteric perfusion in the neonatal intestine[J]. Br J Nutr, 2016, 116(7): 1175-1187. DOI: 10.1017/S0007114516002944. |
| [58] |
Chowning R, Radmacher P, Lewis S, et al. A retrospective analysis of the effect of human milk on prevention of necrotizing enterocolitis and postnatal growth[J]. J Perinatol, 2016, 36(3): 221-224. DOI: 10.1038/jp.2015.179. |
| [59] |
Johnson TJ, Patel AL, Bigger HR, et al. Cost savings of human milk as a strategy to reduce the incidence of necrotizing enterocolitis in very low birth weight infants[J]. Neonatology, 2015, 107(4): 271-276. DOI: 10.1159/000370058. |
| [60] |
Berkhout D, Klaassen P, Niemarkt HJ, et al. Risk factors for necrotizing enterocolitis: a prospective multicenter case-control study[J]. Neonatology, 2018, 114(3): 277-284. DOI: 10.1159/000489677. |
| [61] |
Siggers RH, Siggers J, Thymann T, et al. Nutritional modulation of the gut microbiota and immune system in preterm neonates susceptible to necrotizing enterocolitis[J]. J Nutr Biochem, 2011, 22(6): 511-521. DOI: 10.1016/j.jnutbio.2010.08.002. |
| [62] |
Sodhi CP, Fulton WB, Good M, et al. Fat composition in infant formula contributes to the severity of necrotising enterocolitis[J]. Br J Nutr, 2018, 120(6): 665-680. DOI: 10.1017/S0007114518001836. |