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中华妇幼临床医学杂志(电子版) ›› 2020, Vol. 16 ›› Issue (06) : 739 -744. doi: 10.3877/cma.j.issn.1673-5250.2020.06.018

所属专题： 文献；

综述

新生儿坏死性小肠结肠炎发病机制的研究进展
马娜1, Mohd Jaish Siddiqui1, 夏斌1,†()   
  1. 1. 四川大学华西第二医院儿科、出生缺陷与相关妇儿疾病教育部重点实验室，成都　610041
  • 收稿日期:2020-07-18 修回日期:2020-11-06 出版日期:2020-12-01
  • 通信作者: 夏斌

Research progresses of pathogenesis of neonatal necrotizing enterocolitis

Na Ma1, Mohd Jaish Siddiqui1, Bin Xia1,†()   

  1. 1. Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2020-07-18 Revised:2020-11-06 Published:2020-12-01
  • Corresponding author: Bin Xia
  • Supported by:
    National Natural Science Foundation of China(81370738)
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引用本文：

马娜, Mohd Jaish Siddiqui, 夏斌. 新生儿坏死性小肠结肠炎发病机制的研究进展[J]. 中华妇幼临床医学杂志(电子版), 2020, 16(06): 739-744.

Na Ma, Mohd Jaish Siddiqui, Bin Xia. Research progresses of pathogenesis of neonatal necrotizing enterocolitis[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2020, 16(06): 739-744.

新生儿坏死性小肠结肠炎(NEC)，是新生儿重症监护病房常见的危重胃肠道炎症性疾病，严重危及患儿生命。目前认为导致NEC的主要危险因素包括早产、肠道菌群失调、炎症反应、输注血液制品及喂养不当等，但是该病的具体发病机制迄今尚未明确。笔者拟就目前有关NEC发病机制的最新研究进行综述。

关键词: 小肠结肠炎, 坏死性, 婴儿, 早产, 炎症, 胃肠道微生物群, 输血, 危险因素, 病因学, 婴儿, 新生

Neonatal necrotizing enterocolitis (NEC) is the frequent and lethal gastrointestinal inflammation disease in neonatal intensive care units, and seriously endangering the life of neonates. At present, the main risk factors of NEC consist of prematurity, microbiome dysbiosis, inflammatory reaction, blood products transfusion and improper feeding, etc., but the pathogenesis of NEC is not identify yet. This article reviews the latest research on the pathogenesis of NEC in recent years.

Key words: Enterocolitis, necrotizing, Infant, premature, Inflammation, Gastrointestinal microbiome, Blood transfusion, Risk factors, Etiology, Infant, newborn
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