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中华妇幼临床医学杂志(电子版) ›› 2020, Vol. 16 ›› Issue (05) : 519 -526. doi: 10.3877/cma.j.issn.1673-5250.2020.05.004

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Notch信号通路与妊娠相关疾病发生与发展的研究现状
蒋敏1, 谢艳艳2, 姚延娇2, 卢丹1,†()   
  1. 1. 扬州大学临床医学院、江苏省苏北人民医院妇产科　225001
    2. 大连医科大学　116044
  • 收稿日期:2020-01-03 修回日期:2020-09-01 出版日期:2020-10-01
  • 通信作者: 卢丹

Current research status of Notch signaling pathway and the occurrence and development of pregnancy-related diseases

Min Jiang1, Yanyan Xie2, Yanjiao Yao2, Dan Lu1,†()   

  1. 1. Clinical Medical College, Yangzhou University, Department of Obstetrics and Gynecology, Northern Jiangsu People′s Hospital, Yangzhou 225001, Jiangsu Province, China
    2. Dalian Medical University, Dalian 116044, Liaoning Province, China
  • Received:2020-01-03 Revised:2020-09-01 Published:2020-10-01
  • Corresponding author: Dan Lu
  • Supported by:
    Scientific Research Project of Maternal and Child Health in Jiangsu Province(F201663); Project of Science and Technology Plan in Yangzhou City(YZ2017075)
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蒋敏, 谢艳艳, 姚延娇, 卢丹. Notch信号通路与妊娠相关疾病发生与发展的研究现状[J]. 中华妇幼临床医学杂志(电子版), 2020, 16(05): 519-526.

Min Jiang, Yanyan Xie, Yanjiao Yao, Dan Lu. Current research status of Notch signaling pathway and the occurrence and development of pregnancy-related diseases[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2020, 16(05): 519-526.

1917年，在果蝇体内最早发现Notch基因。该基因部分功能缺失，可能造成果蝇翅膀边缘出现缺口，而被命名为Notch基因。研究发现，Notch信号通路是无脊椎动物和脊椎动物在进化过程中高度保守的一类信号通路。目前，Notch信号通路已成为发育学、细胞生物学、免疫学、血液学、肿瘤学等领域的研究热点之一，参与许多疾病的发生与发展过程。对于Notch信号通路与妊娠相关疾病的最新研究认为，Notch信号通路可影响早期滋养细胞(CTB)分化、增殖、浸润及迁移，参与胚胎着床、胎盘及其血管形成，在胎盘血液循环过程中起着重要作用，进而对子痫前期、原因不明复发性自然流产(URSA)、胎儿生长迟缓(FGR)等病理妊娠的发生与发展产生影响。笔者拟就Notch信号通路在妊娠相关疾病发生与发展中的最新研究进展进行阐述。

关键词: 受体, Notch, 配体, Notch, 信号传导, Notch, 妊娠并发症, 胎儿生长迟缓, T淋巴细胞, 胚胎植入, 新生血管化, 病理性, 女(雌)性

Notch gene was originally a gene discovered by Morgan in drosophila in 1917. Part of the gene′s loss of function may cause a gap in the edges of wings of drosophila, so the gene was named as Notch. Studies have found that Notch signaling pathway is a highly conserved type of signaling pathway in evolution process of invertebrates and vertebrates. In recent years, Notch signaling pathway has become one of the research hotspots in many fields, such as auxanology, cell biology, immunology, hematology and oncology. And it participates in the occurrence and development of many diseases shows that latest research on Notch signaling pathway and pregnancy-related diseases shows that the Notch signaling pathway can affect differentiation, proliferation, infiltration and migration of early cytotrophoblasts (CTB), participate in embryo implantation, placenta and its blood vessel formation, play an important role in the blood circulation of placenta, and then it has a certain impact on the occurrence and development of pathological pregnancy, such as preeclampsia, unexplained recurrent spontaneous abortion (URSA) and fetal growth restriction (FGR) and so on. This article focuses on the latest research progress of Notch signaling pathway in pregnancy-related diseases.

Key words: Receptors, Notch, Ligands, Notch, Signal transduction, Notch, Pregnancy complications, Fetal growth retardation, T-lymphocytes, Embryo implantation, Neovascularization, pathologic, Female
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