Notch信号通路与妊娠相关疾病发生与发展的研究现状

doi:10.3877/cma.j.issn.1673-5250.2020.05.004

中华妇幼临床医学杂志(电子版) ›› 2020, Vol. 16 ›› Issue (05) : 519 -526. doi: 10.3877/cma.j.issn.1673-5250.2020.05.004

所属专题：文献；

专题论坛

Notch信号通路与妊娠相关疾病发生与发展的研究现状

蒋敏¹, 谢艳艳², 姚延娇², 卢丹¹^,^†(

)

^1. 扬州大学临床医学院、江苏省苏北人民医院妇产科　225001
^2. 大连医科大学　116044

收稿日期:2020-01-03 修回日期:2020-09-01 出版日期:2020-10-01
通信作者: 卢丹

Current research status of Notch signaling pathway and the occurrence and development of pregnancy-related diseases

Min Jiang¹, Yanyan Xie², Yanjiao Yao², Dan Lu¹^,^†()

^1. Clinical Medical College, Yangzhou University, Department of Obstetrics and Gynecology, Northern Jiangsu People′s Hospital, Yangzhou 225001, Jiangsu Province, China
^2. Dalian Medical University, Dalian 116044, Liaoning Province, China

Received:2020-01-03 Revised:2020-09-01 Published:2020-10-01
Corresponding author: Dan Lu
Supported by:
Scientific Research Project of Maternal and Child Health in Jiangsu Province(F201663); Project of Science and Technology Plan in Yangzhou City(YZ2017075)

全文 ( ) 下载PDF ( ) 导出引用

引用本文：

蒋敏, 谢艳艳, 姚延娇, 卢丹. Notch信号通路与妊娠相关疾病发生与发展的研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2020, 16(05): 519-526.

Min Jiang, Yanyan Xie, Yanjiao Yao, Dan Lu. Current research status of Notch signaling pathway and the occurrence and development of pregnancy-related diseases[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2020, 16(05): 519-526.

1917年，在果蝇体内最早发现Notch基因。该基因部分功能缺失，可能造成果蝇翅膀边缘出现缺口，而被命名为Notch基因。研究发现，Notch信号通路是无脊椎动物和脊椎动物在进化过程中高度保守的一类信号通路。目前，Notch信号通路已成为发育学、细胞生物学、免疫学、血液学、肿瘤学等领域的研究热点之一，参与许多疾病的发生与发展过程。对于Notch信号通路与妊娠相关疾病的最新研究认为，Notch信号通路可影响早期滋养细胞(CTB)分化、增殖、浸润及迁移，参与胚胎着床、胎盘及其血管形成，在胎盘血液循环过程中起着重要作用，进而对子痫前期、原因不明复发性自然流产(URSA)、胎儿生长迟缓(FGR)等病理妊娠的发生与发展产生影响。笔者拟就Notch信号通路在妊娠相关疾病发生与发展中的最新研究进展进行阐述。

关键词: 受体, Notch, 配体, Notch, 信号传导, Notch, 妊娠并发症, 胎儿生长迟缓, T淋巴细胞, 胚胎植入, 新生血管化, 病理性, 女(雌)性

Notch gene was originally a gene discovered by Morgan in drosophila in 1917. Part of the gene′s loss of function may cause a gap in the edges of wings of drosophila, so the gene was named as Notch. Studies have found that Notch signaling pathway is a highly conserved type of signaling pathway in evolution process of invertebrates and vertebrates. In recent years, Notch signaling pathway has become one of the research hotspots in many fields, such as auxanology, cell biology, immunology, hematology and oncology. And it participates in the occurrence and development of many diseases shows that latest research on Notch signaling pathway and pregnancy-related diseases shows that the Notch signaling pathway can affect differentiation, proliferation, infiltration and migration of early cytotrophoblasts (CTB), participate in embryo implantation, placenta and its blood vessel formation, play an important role in the blood circulation of placenta, and then it has a certain impact on the occurrence and development of pathological pregnancy, such as preeclampsia, unexplained recurrent spontaneous abortion (URSA) and fetal growth restriction (FGR) and so on. This article focuses on the latest research progress of Notch signaling pathway in pregnancy-related diseases.

Key words: Receptors, Notch, Ligands, Notch, Signal transduction, Notch, Pregnancy complications, Fetal growth retardation, T-lymphocytes, Embryo implantation, Neovascularization, pathologic, Female

[1]	张悦，马蕾，薛海波，等. Notch信号通路调控调节性T细胞分化与功能的研究进展[J]. 现代免疫学，2018, 38(2): 162-165.
[2]	Steinbuck MP, Arakcheeva K, Winandy S. Novel TCR-mediated mechanisms of notch activation and signaling [J]. J Immunol, 2018, 200(3): 997-1007. DOI: 10.4049/jimmunol.1700070.
[3]	任文汇，王春梅，李楠. Notch信号通路在B细胞分化发育以及B细胞淋巴瘤中作用的研究进展[J]. 中国肿瘤生物治疗杂志，2016, 23(2): 282-286. DOI: 10.3872/j.issn.1007-385X.2016.02.021.
[4]	Nakano N, Nishiyama C, Yagita H, et al. Notch signaling enhances FcεRI-mediated cytokine production by mast cells through direct and indirect mechanisms [J]. J Immunol, 2015, 194(9): 4535-4544. DOI: 10.4049/jimmunol.1301850.
[5]	Cemgil Arikan D, Aral M, Coskun A, et al. Plasma IL-4, IL-8, IL-12, interferon-î³ and CRP levels in pregnant women with preeclampsia, and their relation with severity of disease and fetal birth weight [J]. J Matern Fetal Neonatal Med, 2012, 25(9): 1569-1573. 10.3109/14767058.2011.648233.
[6]	Campese AF, Grazioli P, de Cesaris P, et al. Mouse sertoli cells sustain de novo generation of regulatory T cells by triggering the notch pathway through soluble JAGGED1 [J]. Biol Reprod, 2014, 90(3): 53. DOI: 10.1095/biolreprod.113.113803.
[7]	Le Friec G, Sheppard D, Whiteman P, et al. The CD46-Jagged1 interaction is critical for human TH1 immunity [J]. Nat Immunol, 2012, 13(12): 1213-1221. DOI: 10.1038/ni.2454.
[8]	Dongre A, Surampudi L, Lawlor RG, et al. Non-canonical notch signaling drives activation and differentiation of peripheral CD4^＋ T cells [J]. Front Immunol, 2014, 5: 54. DOI: 10.1038/ni.2454.
[9]	谢东杰，王爱迪，吴晶魁，等. Notch信号通路对CD4^＋T细胞分化及功能调控的研究进展[J]. 免疫学杂志，2017, 33(12): 1100-1104. DOI: 10.13431/j.cnki.immunol.j.20170191.
[10]	Roderick JE, Gonzalezperez G, Kuksin CA, et al. Therapeutic targeting of Notch signaling ameliorates immune-mediated bone marrow failure of aplastic anemia [J]. J Exp Med, 2013, 210(7): 1311-1329. DOI: 10.1084/jem.20112615.
[11]	Verma NK, Fazil MH, Ong ST, et al. LFA-1/ICAM-1 ligation in human T cells promotes Th1 polarization through a GSK3β signaling-dependent Notch pathway [J]. J Immunol, 2016, 197(1): 108-118. DOI: 10.4049/jimmunol.1501264.
[12]	Jiang S, Han S, Chen J, et al. Inhibition effect of blunting Notch signaling on food allergy through improving TH1/TH2 balance in mice [J]. Ann Allergy Asthma Immunol, 2017, 18(1): 94-102. DOI: 10.1016/j.anai.2016.10.024.
[13]	陈振振，贡欣. Th17/Treg细胞免疫失衡与妊娠相关疾病的研究进展[J]. 医学综述，2017, 23(17): 3359-3362. DOI: 10.3969/j.issn.1006-2084.2017.17.007.
[14]	黄千贻，李慕军. Treg/Th17平衡与复发性流产[J]. 中国免疫学杂志，2015, 31(10): 1422-1425. DOI: 10.3969/j.issn.1000-484X.2015.10.029.
[15]	Keerthivasan S, Suleiman R, Lawlor R, et al. Notch signaling regulates mouse and human Th17 differentiation [J]. J Immunol, 2011, 187(2): 692-701. DOI: 10.4049/jimmunol.1003658.
[16]	Wongchana W, Lawlor RG, Osborne BA, et al. Impact of Notch1 deletion in macrophages on pro-inflammatory cytokine production and the outcome of experimental autoimmune encephalomyelitis [J]. J Immunol, 2015, 195(11): 5337. DOI: 10.4049/jimmunol.1401770.
[17]	Rong H, Shen H, Xu Y, et al. Notch signaling suppresses regulatory T cell function in murine experimental autoimmune uveitis [J]. Immunology, 2016, 149(4): 447-459. DOI: 10.1111/imm.12663.
[18]	Yao Y, Song J, Wang W, et al. Decidual vascular endothelial cells promote maternal-fetal immune tolerance by inducing regulatory T cells through canonical Notch1 signaling [J]. Immunol Cell Biol, 2017, 95(4): 416. DOI: 10.1038/icb.2017.12.
[19]	王晨曦，林其德，戴良图，等. Notch1蛋白在正常妊娠早中晚期胎盘绒毛中的表达变化及其意义[J]. 现代妇产科进展，2013, 22(3): 199-201. DOI: 10.13431/j.cnki.immunol.j.20170191.
[20]	Cuman C, Menkhorst EM, Rombauts LJ, et al. Preimplantation human blastocysts release factors that differentially alter human endometrial epithelial cell adhesion and gene expression relative to IVF success [J]. Hum Reprod, 2013, 28(5): 1161-1171. DOI: 10.1093/humrep/det058.
[21]	黄静，孙大光，张益，等. Notch1在先兆子痫胎盘组织中的表达[J]. 重庆医科大学学报，2013, 38(10): 1159-1162. DOI: 10.11699/cyxb20131014.
[22]	赵先兰，陶雅，王永红，等. Notch信号通路配体Jagged1、Dll4在子痫前期胎盘组织中的表达[J]. 郑州大学学报(医学版), 2017, 52(3): 359-362. DOI: 10.13705/j.issn.1671-6825.2017.03.029.
[23]	李巧云，吕冉冉，李广太，等. Notch1及其配体DLL4在子痫前期患者胎盘组织中的表达[J]. 中华妇产科杂志，2013, 48(11): 862-864. DOI: 10.3760/cma.j.issn.0529-567x.2013.11.014.
[24]	洪日，戚基萍，吴鹤. Notch信号通路在血管生成方面的作用[J]. 医学综述，2017, 23(21): 4189-4193. DOI: 10.3969/j.issn.1006-2084.2017.21.006.
[25]	Maynard S, Epstein FH, Karumanchi SA. Preeclampsia and angiogenic imbalance [J]. Ann Rev Med, 2008, 59: 61. DOI: 10.1146/annurev.med.59.110106.214058.
[26]	Velicky P, Haider S, Otti GR, et al. Notch-dependent RBP-Jκ inhibits proliferation of human cytotrophoblasts and their differentiation into extravillous trophoblasts [J]. Mol Hum Reprod, 2014, 20(8): 756-766. DOI: 10.1093/molehr/gau038.
[27]	Tang L, Gao C, Gao L, et al. Expression profile of micro-RNAs and functional annotation analysis of their targets in human chorionic villi from early recurrent miscarriage [J]. Gene, 2016, 576(1): 366-371. DOI: 10.1016/j.gene.2015.10.047.
[28]	刘卓，李益亮，张志，等. Notch4受体对血管新生的影响[J]. 中医正骨，2016, 28(6): 56-58.
[29]	Moya IM, Umans L, Maas E, et al. Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades [J]. Dev Cell, 2012, 22(3): 501-514. DOI: 10.1016/j.devcel.2012.01.007.
[30]	谢幸，苟文丽. 妇产科学[M]. 8版. 北京：人民卫生出版社，2013: 64-65.
[31]	赵先兰，王永红，刘彩. Notch信号通路配体Jagged1在子痫前期胎盘组织中的表达及其与胎盘血管形成的关系[J]. 中华妇产科杂志，2016, 51(9): 693-696. DOI: 10.3760/cma.j.issn.0529-567x.2016.09.011.
[32]	赵明智，牛甜甜，李明清，等. 调节性T细胞和Notch1信号通路在原因不明复发性自然流产中的作用[J]. 中华生殖与避孕杂志，2017, 37(6): 469-473. DOI: 10.3760/cma.j.issn.2096-2916.2017.06.009.
[33]	印永祥，韩晓枫，赵益明，等. 原因不明复发性流产中CD4^＋ Notch1^＋ T细胞与IL-10的相关性分析[J]. 标记免疫分析与临床，2010, 17(3): 157-160. DOI: 10.3969/j.issn.1006-1703.2010.03.009.
[34]	Fang Y, Yu S, Ma Y, et al. Association of Dll4/notch and HIF-1a-VEGF signaling in the angiogenesis of missed abortion [J]. PLoS One, 2013, 8(8): e70667. DOI: 10.1371/journal.pone.0070667.
[35]	Nanjo S, Matsushita A, Yahata T, et al. Expression of Notch signaling in placental tissues with preeclampsia (PE) and/or fetal growth restriction (FGR) [J]. Placenta, 2016, 46: 107-108. DOI: 10.1016/j.placenta.2016.08.022.
[36]	Sahin Z, Acar N, Ozbey O, et al. Distribution of Notch family proteins in intrauterine growth restriction and hypertension complicated human term placentas [J]. Acta Histochem, 2011, 113(3): 270-276. DOI: 10.1016/j.acthis.2009.10.006.
[37]	Gundogan F, Bedoya A, Gilligan J, et al. SI-RNA inhibition of aspartyl-asparaginyl β-hydroxylase expression impairs cell motility, Notch signaling, and fetal growth [J]. Pathol Res Pract, 2011, 207(9): 545-553. DOI: 10.1016/j.prp.2011.06.001.

[1]	刘晨鹭, 刘洁, 张帆, 严彩英, 陈倩, 陈双庆. 增强MRI 影像组学特征生境分析在预测乳腺癌HER-2 表达状态中的应用[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(06): 339-345.
[2]	张启龙, 柳亿, 卢会丽, 罗慧, 李成林, 王菁, 王辉. 奥妥珠单抗治疗磷脂酶A2受体相关膜性肾病的疗效与安全性：单中心回顾性分析[J/OL]. 中华危重症医学杂志(电子版), 2024, 17(05): 379-384.
[3]	宋勤琴, 李双汝, 李林, 杜鹃, 刘继松. 间充质干细胞源性外泌体在改善病理性瘢痕中作用的研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(06): 550-553.
[4]	笪东祝, 林凯, 王小蕊, 王开银, 王敏, 王玮, 李瑾, 刘俊. 低促甲状腺激素水平结节性甲状腺肿的发生发展与促甲状腺激素受体基因D727E 多态性的相关性研究[J/OL]. 中华普通外科学文献(电子版), 2024, 18(06): 443-446.
[5]	赖全友, 高远, 汪建林, 屈士斌, 魏丹, 彭伟. 三维重建技术结合腹腔镜精准肝切除术对肝癌患者术后CD4+、CD8+及免疫球蛋白水平的影响[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 651-654.
[6]	黄福, 王黔, 金相任, 唐云川. VEGFR2、miR-27a-5p在胃癌组织中的表达与临床病理参数及预后的关系研究[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(05): 558-561.
[7]	郑俊, 吴杰英, 谭海波, 郑安全, 李腾成. EGFR-MEK-TZ三联合分子的构建及其对去势抵抗性前列腺癌细胞增殖与凋亡的影响[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(05): 503-508.
[8]	胡思平, 熊性宇, 徐航, 杨璐. 衰老相关分泌表型因子在前列腺癌发生发展中的作用机制[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(05): 425-434.
[9]	赖淼, 景鑫, 李桂珍, 李怡. 非小细胞肺癌EGFR 突变亚型的临床病理和预后意义[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 731-737.
[10]	梁丽斯, 李洁, 贺帅, 来艳君, 刘铭, 张琳. MMP-9、MMP-2 及TLR4、HE4对非小细胞肺癌早期诊断意义[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 756-761.
[11]	刘先勇, 秦东梅, 张若梅, 李俊娇, 孟春芹, 邬明歆, 王玉红, 赵新鲜, 徐瑞联, 洪文文, 马玲, 仇玮, 周宇. Her2/Hes1在肠型胃癌Correa级联反应3个病理阶段中的表达及意义[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(06): 321-327.
[12]	陈伟杰, 何小东. 胆囊癌免疫靶向治疗进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 763-768.
[13]	张英信, 林婷, 张剑文. 构建靶向HLA-A2且表达PD-L1的CAR-Treg细胞及验证其对CD4⁺T细胞抑制作用[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 719-728.
[14]	吴东阳, 林向丹, 石佐林, 赵玉龙, 王振, 文安国, 纪鑫, 李俊之, 赵明光. NF-L、NLRP3、S100B 蛋白在颅脑损伤严重程度及预后评估中的应用价值[J/OL]. 中华神经创伤外科电子杂志, 2024, 10(05): 279-285.
[15]	李润东, 豆小文, 张秀明. 失笑散联合胃复春治疗慢性萎缩性胃炎的疗效及对血清免疫受体和炎症因子水平的影响[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(05): 470-473.

阅读次数

全文

摘要

选择文件类型/文献管理软件名称

选择包含的内容

Current research status of Notch signaling pathway and the occurrence and development of pregnancy-related diseases

模态框（Modal）标题

选择文件类型/文献管理软件名称

选择包含的内容

Current research status of Notch signaling pathway and the occurrence and development of pregnancy-related diseases