[1] |
|
[2] |
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017 [J]. CA Cancer J Clin, 2017, 67(1): 7-30. DOI: 10.3322/caac.21387.
|
[3] |
Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA Cancer J Clin, 2018, 68(6): 394-424. DOI: 10.3322/caac.21492.
|
[4] |
|
[5] |
Liu HQ, Wang YH, Wang LL, et al. P16INK4A and survivin: diagnostic and prognostic markers in cervical intraepithelial neoplasia and cervical squamous cell carcinoma [J]. Exp Mol Pathol, 2015, 99(1): 44-49. DOI: 10.1016/j.yexmp.2015.04.004.
|
[6] |
|
[7] |
Yang J, Yang A, Wang Z, et al. Interactions between serum folate and human papillomavirus with cervical intraepithelial neoplasia risk in a Chinese population-based study [J]. Am J Clin Nutr, 2018, 108(5): 1034-1042. DOI: 10.1093/ajcn/nqy160.
|
[8] |
|
[9] |
Wetmore C. Sonic hedgehog in normal and neoplastic proliferation: insight gained from human tumors and animal models [J]. Curr Opin Genet Dev, 2003, 13(1): 34-42. DOI: 10.1016/s0959-437x(03)00002-9.
|
[10] |
Sahebjam S, Siu LL, Razak AA. The utility of hedgehog signaling pathway inhibition for cancer [J]. Oncologist, 2012, 17(8): 1090-1099. DOI: 10.1634/theoncologist.2011-0450.
|
[11] |
Jia Y, Wang Y, Xie J. The Hedgehog pathway: role in cell differentiation, polarity and proliferation [J]. Arch Toxicol, 2015, 89(2): 179-191. DOI: 10.1007/s00204-014-1433-1.
|
[12] |
Niewiadomski P, Niedzióka SM, Markiewicz ,et al. Gli proteins: regulation in development and cancer [J]. Cells, 2019, 8(2): 147. DOI: 10.3390/cells8020147.
|
[13] |
Ruiz i Altaba A, Sánchez P, Dahmane N. Gli and hedgehog in cancer: tumours, embryos and stem cells [J]. Nat Rev Cancer, 2002, 2(5): 361-372. DOI: 10.1038/nrc796.
|
[14] |
Matise MP, Joyner AL. Gli genes in development and cancer [J]. Oncogene, 1999, 18(55): 7852-7859. DOI: 10.1038/sj.onc.1203243.
|
[15] |
Kim YI, Shirwadkar S, Choi SW, et al. Effects of dietary folate on DNA strand breaks within mutation-prone exons of the p53 gene in rat colon [J]. Gastroenterology, 2000, 119(1): 151-161. DOI: 10.1053/gast.2000.8518.
|
[16] |
Chaudary N, Pintilie M, Hedley D, et al. Hedgehog inhibition enhances efficacy of radiation and cisplatin in orthotopic cervical cancer xenografts [J]. Br J Cancer, 2017, 116(1): 50-57. DOI: 10.1038/bjc.2016.383.
|
[17] |
Zhang F, Ren CC, Liu L, et al. SHH gene silencing suppresses epithelial-mesenchymal transition, proliferation, invasion, and migration of cervical cancer cells by repressing the hedgehog signaling pathway [J]. J Cell Biochem, 2018, 119(5): 3829-3842. DOI: 10.1002/jcb.26414.
|
[18] |
Katoh M, Katoh M. Transcriptional regulation of WNT2B based on the balance of Hedgehog, Notch, BMP and WNT signals [J]. Int J Oncol, 2009, 34(5): 1411-1415.
|
[19] |
Xuan YH, Jung HS, Choi YL, et al. Enhanced expression of hedgehog signaling molecules in squamous cell carcinoma of uterine cervix and its precursor lesions [J]. Mod Pathol, 2006, 19(8): 1139-1147. DOI: 10.1038/modpathol.3800600.
|
[20] |
Kitazawa S, Kitazawa R, Tamada H, et al. Promoter structure of human sonic hedgehog gene [J]. Biochim Biophys Acta, 1998, 1443(3): 358-363. DOI: 10.1016/s0167-4781(98)00243-7.
|
[21] |
Feng HC, Lin JY, Hsu SH, et al. Low folate metabolic stress reprograms DNA methylation-activated sonic hedgehog signaling to mediate cancer stem cell-like signatures and invasive tumour stage-specific malignancy of human colorectal cancers [J]. Int J Cancer, 2017, 141(12): 2537-2550. DOI: 10.1002/ijc.31008.
|
[22] |
Wang TP, Hsu SH, Feng HC, et al. Folate deprivation enhances invasiveness of human colon cancer cells mediated by activation of sonic hedgehog signaling through promoter hypomethylation and cross action with transcription nuclear factor-kappa B pathway [J]. Carcinogenesis, 2012, 33(6): 1158-1168. DOI: 10.1093/carcin/bgs138.
|
[23] |
Chen WJ, Huang RS. Low-folate stress reprograms cancer stem cell-like potentials and bioenergetics metabolism through activation of mTOR signaling pathway to promote in vitro invasion and in vivo tumorigenicity of lung cancers [J]. J Nutr Biochem, 2018, 53: 28-38. DOI: 10.1016/j.jnutbio.2017.10.001.
|
[24] |
Zhang W, Wu X, Hu L, et al. Overexpression of human papillomavirus type 16 oncoproteins enhances epithelial-mesenchymal transition via STAT3 signaling pathway in non-small cell lung cancer cells [J]. Oncol Res, 2017, 25(5): 843-852. DOI: 10.3727/096504016X14813880882288.
|
[25] |
Stamos JL, Weis WI. The β-catenin destruction complex [J]. Cold Spring Harb Perspect Biol, 2013, 5(1): a007898. DOI: 10.1101/cshperspect.a007898.
|
[26] |
Levine AJ, Oren M. The first 30 years of p53: growing ever more complex [J]. Nat Rev Cancer, 2009, 9(10): 749-758. DOI: 10.1038/nrc2723.
|
[27] |
|
[28] |
Zhang YF, Zhou L, Zhang HW, et al. Association between folate intake and the risk of lung cancer: a dose-response Meta-analysis of prospective studies [J]. PLoS One, 2014, 9(4): e93465. DOI: 10.1371/journal.pone.0093465.
|
[29] |
Moon RT, Kohn AD, De Ferrari GV, et al. WNT and beta-catenin signalling: diseases and therapies [J]. Nat Rev Genet, 2004, 5(9): 691-701. DOI: 10.1038/nrg1427.
|
[30] |
Nobori T, Miura K, Wu DJ, et al. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers [J]. Nature, 1994, 368(6473): 753-756. DOI: 10.1038/368753a0.
|
[31] |
Walker DG, Duan W, Popovic EA, et al. Homozygous deletions of the multiple tumor suppressor gene 1 in the progression of human astrocytomas [J]. Cancer Res, 1995, 55(1): 20-23.
|
[32] |
D′Amico M, Wu K, Fu M, et al. The inhibitor of cyclin-dependent kinase 4a/alternative reading frame (INK4a/ARF) locus encoded proteins p16INK4a and p19ARF repress cyclin D1 transcription through distinct cis elements [J]. Cancer Res, 2004, 64(12): 4122-4130. DOI: 10.1158/0008-5472.CAN-03-2519.
|
[33] |
Liao GD, Sellors JW, Sun HK, et al. p16INK4A immunohistochemical staining and predictive value for progression of cervical intraepithelial neoplasia grade 1: a prospective study in China [J]. Int J Cancer, 2014, 134(7): 1715-1724. DOI: 10.1002/ijc.28485.
|
[34] |
Zhang Q, Kuhn L, Denny LA, et al. Impact of utilizing p16INK4A immunohistochemistry on estimated performance of three cervical cancer screening tests [J]. Int J Cancer, 2007, 120(2): 351-356. DOI: 10.1002/ijc.22172.
|
[35] |
Piyathilake CJ, Macaluso M, Brill I, et al. Lower red blood cell folate enhances the HPV-16-associated risk of cervical intraepithelial neoplasia [J]. Nutrition, 2007, 23(3): 203-210. DOI: 10.1016/j.nut.2006.12.002.
|
[36] |
|
[37] |
Miller DS, Blessing JA, Bodurka DC, et al. Evaluation of pemetrexed (Alimta, LY231514) as second line chemotherapy in persistent or recurrent carcinoma of the cervix: a phase Ⅱ study of the Gynecologic Oncology Group [J]. Gynecol Oncol, 2008, 110(1): 65-70. DOI: 10.1016/j.ygyno.2008.03.009.
|
[38] |
Goedhals L, van Wiyk AL, Smith BL, et al. Pemetrexed (Alimta, LY231514) demonstrates clinical activity in chemonaive patients with cervical cancer in a phase Ⅱ single-agent trial [J]. Int J Gynecol Cancer, 2006, 16(3): 1172-1178. DOI: 10.1111/j.1525-1438.2006.00451.x.
|
[39] |
Eifel Patricia J, Winter Kathryn, Morris Mitchell, et al. Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of radiation therapy oncology group trial (RTOG) 90-01 [J]. J Clin Oncol, 2004, 22(5): 872-880. DOI: 10.1200/JCO.2004.07.197.
|