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中华妇幼临床医学杂志(电子版) ›› 2018, Vol. 14 ›› Issue (04) : 373 -377. doi: 10.3877/cma.j.issn.1673-5250.2018.04.001

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胎儿唇腭裂产前诊断及预后研究现状
徐婷婷1, 王晓东1, 余海燕1,()   
  1. 1. 610041 成都,四川大学华西第二医院妇产科、出生缺陷与相关妇儿疾病教育部重点实验室
  • 收稿日期:2018-01-10 修回日期:2018-05-30 出版日期:2018-08-01
  • 通信作者: 余海燕

Prenatal diagnosis and prognosis of fetal cleft lip and/or palate

Tingting Xu1, Xiaodong Wang1, Haiyan Yu1,()   

  1. 1. Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2018-01-10 Revised:2018-05-30 Published:2018-08-01
  • Corresponding author: Haiyan Yu
  • About author:
    Corresponding author: Yu Haiyan, Email:
  • Supported by:
    Training Project of Academic and Technical Leaders of Sichuan Provincial Human Resources and Social Security Department([2016]183-31); Project of Science and Technology Bureau of Chengdu(2014-HM01-00039-SF)
引用本文:

徐婷婷, 王晓东, 余海燕. 胎儿唇腭裂产前诊断及预后研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2018, 14(04): 373-377.

Tingting Xu, Xiaodong Wang, Haiyan Yu. Prenatal diagnosis and prognosis of fetal cleft lip and/or palate[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2018, 14(04): 373-377.

唇腭裂是最常见的颜面部畸形,对于该病的病因迄今尚未阐明,目前多认为该病是由于遗传、环境因素共同作用所致。中孕期通过超声、MRI等辅助检查方法可诊断胎儿唇腭裂。部分胎儿唇腭裂合并其他畸形,部分存在基因、染色体异常,影响患儿出生后生存质量及预后等,因此产前对胎儿唇腭裂的明确诊断至关重要。胎儿唇腭裂宫内手术治疗目前尚处于研究阶段,非综合征性唇腭裂(NSCL/P)患儿于婴幼儿期进行手术治疗后,多数可以康复。笔者拟就胎儿唇腭裂产前诊断及预后研究现状进行阐述,以提高临床对该病的诊治水平。

Cleft lip and/or palate are common facial deformities. Its etiology is still unknown, which may be due to genetic factors and environmental factors. Fetal cleft lip and/or palate can be auxiliarily diagnosed by ultrasonography and MRI. Complicated cases of fetal cleft lip and/or palate may be combined with other deformities and/or genes or chromosomal abnormalities, which affect survivors′ life quality and prognosis. So the definitive diagnosis of fetal cleft lip and/or palate is crucial. Fetal intrauterine surgery of cleft lip and/or palate is still in the research stage. The majority of non-syndromic cleft lip and/or palate (NSCL/P) can be corrected after birth by surgery in infancy. The authors intend to focus on the prenatal diagnosis and prognosis of fetal cleft lip and/or palate, in order to improve the diagnosis and treatment abilities of fetal cleft lip and/or palate.

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