探讨采用GoPubMed对乳腺癌的相关研究文献进行文献计量学分析的可行性。

采用文献计量学分析方法，选择"breast neoplasms" "breast cancer" "breast carcinoma" "mammary neoplasms"等为检索词，检索2004年1月1日至2016年4月29日被PubMed数据库收录的乳腺癌相关研究文献，共计获得符合本研究纳入、排除标准的文献98 462篇为研究对象。统计学分析其乳腺癌相关研究文献的高频主题词及发表文献的年份、国家、城市和期刊分布情况，以及研究方向，了解乳腺癌研究的现状及其发展趋势。

在2004－2015年，PubMed数据库收录的乳腺癌相关研究的发文量呈逐年上升趋势。本研究在PubMed数据库检索到的98 462篇乳腺癌相关研究文献中，发文量最多的国家为美国和中国，而发文量较大的地区和城市，则集中在北美和欧洲等西方发达国家，我国的北京和上海位列前10位发文量较大的城市之中。乳腺癌相关研究发文量较大的期刊，则主要集中在欧、美国家出版的期刊上，前10位发文量较大的期刊中，亚洲出版的期刊仅有1种。目前有关乳腺癌的研究，主要集中在该病发病年龄、基因突变和蛋白等方面。

采用GoPubMed检索到的乳腺癌相关研究文献，能较好反映乳腺癌研究的现状和发展趋势。本研究对全球乳腺癌相关研究发文量的文献计量学分析结果可见，目前对乳腺癌的研究国家，主要集中在北美和欧洲国家。中国乳腺癌发文量位居世界第2位，主要集中在北京、上海2座城市，其他地区的乳腺癌研究发文量相对较小。

To study the feasibility of GoPubMed to research status on breast cancer by bibliometric analysis method.

According to bibliometric analysis method, " breast neoplasms" " breast cancer" " breast carcinoma" and " mammary neoplasms" were selected as docuterms, 98 462 literatures on breast cancer research, which were in accordance with the inclusion and exclusion criteria of this study, from January 1, 2004 to April 29, 2016 in PubMed database were included as study subjects. The research situation and development trend of research on breast cancer were studied by statistical analysis of high-frequency key words and published year, country, city, the distribution of journals and the research trend of breast cancer.

The number of published literatures of research on breast cancer showed a gradual upward trend included in PubMed database from 2004 to 2015. United States and China were the countries with the top two largest amount of published literatures on breast cancer research in PubMed database within the time of literature retrieval among 98 462, areas and cities with large amount of published literatures were concentrated in the countries of North America and Europe. Beijing and Shanghai were among the top 10 cities with a large amount of published literatures on breast cancer research. Magazines which published a large amount of literatures on breast cancer research were concentrated in magazines published by countries in Europe and the United States. Only one kind of magazines published in Asia was among the top 10 magazines with a large amount of published literatures on breast cancer research. At present, the breast cancer research mainly focused on the oneset age, gene mutation and protein and so on.

GoPubMed is a useful tool to research the current situation and development trend on breast cancer. The studies of breast cancer are mainly concentrated in countries of North America and Europe. Research on breast cancer in China is relatively weak besides Beijing and Shanghai.