切换至 "中华医学电子期刊资源库"

中华妇幼临床医学杂志(电子版) ›› 2017, Vol. 13 ›› Issue (01) : 116 -119. doi: 10.3877/cma.j.issn.1673-5250.2017.01.022

所属专题: 文献

综述

B族链球菌相关疫苗的研究进展
高坎坎1, 钟华敏1, 梁绮华1, 刘海英1,()   
  1. 1. 510000 广州医科大学附属广州市妇女儿童医疗中心检验科
  • 收稿日期:2016-07-11 修回日期:2017-01-01 出版日期:2017-02-01
  • 通信作者: 刘海英

Research progress on group B Streptococcal vaccines

Kankan Gao1, Huamin Zhong1, Qihua Liang1, Haiying Liu1,()   

  1. 1. Department of Clinical Laboratory, Guangzhou Women and Children′s Medical Center, Guangzhou Medical University, Guangzhou 510000, Guangdong Province, China
  • Received:2016-07-11 Revised:2017-01-01 Published:2017-02-01
  • Corresponding author: Haiying Liu
  • About author:
    Corresponding author: Liu Haiying, Email:
引用本文:

高坎坎, 钟华敏, 梁绮华, 刘海英. B族链球菌相关疫苗的研究进展[J/OL]. 中华妇幼临床医学杂志(电子版), 2017, 13(01): 116-119.

Kankan Gao, Huamin Zhong, Qihua Liang, Haiying Liu. Research progress on group B Streptococcal vaccines[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2017, 13(01): 116-119.

B族链球菌(GBS)属革兰阳性链球菌,是引起新生儿败血症和脑膜炎的重要致病菌。目前针对GBS采取的主要治疗措施是围生期抗菌药物预防(IAP),可以有效预防早发型GBS疾病(GBS-EOD),但晚发型GBS疾病(GBS-LOD)发生率依然较高。而且随着近年抗菌药物的大量使用,GBS耐药率逐渐增高。因此,GBS疫苗为预防新生儿GBS感染提供了新的方法和途径,特别是荚膜多糖-蛋白结合疫苗,目前已经完成Ⅰ、Ⅱ期临床试验,并且保护性抗体水平的研究已经成为近年来研究的热点。笔者拟对GBS相关疫苗的研究进展进行综述,旨在为GBS疫苗的进一步研制提供参考。

Group B Streptococcal (GBS), a gram-positive Streptococcus, is one of the important pathogenic bacteria which can causes neonatal sepsis and meningitis. The main measure of GBS is intrapartum antibiotics prevention (IAP), which plays an important role in early-onset GBS disease (GBS-EOD), but remains a high infection rates in late-onset GBS disease(GBS-LOD). What′s more, with the extensive use of antimicrobial drugs, the GBS drug resistance rate increased gradually. So that GBS vaccines provide a new method to prevent neonatal GBS infection, especially the capsular polysaccharide conjugate vaccine, the phase Ⅰ and Ⅱ clinical trials have been completed, and the protective antibody levels has been researching. This research will focus on the research progress on GBS vaccines in order to provide reference for further development of GBS vaccines.

[1]
Johri AK, Paoletti LC, Glaser P, et al. Group B Streptococcus: global incidence and vaccine development[J]. Nat Rev Microbiol, 2006, 4(12): 932-942.
[2]
Heath PT, Feldman RG. Vaccination against group B Streptococcus[J]. Expert Rev Vaccines, 2005, 4(2): 207-218.
[3]
Edmond KM, Kortsalioudaki C, Scott S, et al. Group B Streptococcal disease in infants aged younger than 3 months: systematic review and Meta-analysis[J]. Lancet, 2012, 379(9815): 547-556.
[4]
朱敏,范建霞,程利南.围产期B族链球菌感染的研究进展[J].中华妇产科杂志,2005,40(2):137-141.
[5]
Liu H, Zeng H, Wang W, et al. Estimating the burden of invasive Group B Streptococcal disease in young infants in southern mainland China: an observational study[J]. Int J Clin Exp Med, 2015, 8(8): 13699-13707.
[6]
Wang P, Ma Z, Tong J, et al. Serotype distribution, antimicrobial resistance, and molecular characterization of invasive group B Streptococcus isolates recovered from Chinese neonates[J]. Int J Infect Dis, 2015, 37(2): 115-118.
[7]
Schrag SJ, Verani JR. Intrapartum antibiotic prophylaxis for the prevention of perinatal group B Streptococcal disease: experience in the United States and implications for a potential group B Streptococcal vaccine[J]. Vaccine, 2013, 31(Suppl 4): D20-D26.
[8]
Johri AK, Lata H, Yadav P, et al. Epidemiology of group B Streptococcus in developing countries[J]. Vaccine, 2013, 31(Suppl 4): D43-D45.
[9]
Montagu D, Yamey G, Visconti A, et al. Where do poor women in developing countries give birth? A multi-country analysis of demographic and health survey data[J]. PLoS One, 2011, 6(2): e17155.
[10]
Edwards MS, Gonik B. Preventing the broad spectrum of perinatal morbidity and mortality through group B Streptococcal vaccination[J]. Vaccine, 2013, 31(Suppl 4): D66-D71.
[11]
Melin P. Neonatal group B Streptococcal disease: from pathogenesis to preventive strategies[J]. Clin Microbiol Infect, 2011, 17(9): 1294-1303.
[12]
Sweet LR, Gibbs RS.女性生殖道感染性疾病.董建春,王波,译.4版.济南:山东科学技术出版社,2012: 31-45.
[13]
漆洪波.《孕前和孕期保健指南(第1版)》解读[C]//中华围产医学杂志社.第三届围产医学新进展高峰论坛论文集,重庆,2011.
[14]
Verani JR, Schrag SJ. Group B Streptococcal disease in infants: progress in prevention and continued challenges[J]. Clin Perinatol,2010, 37(2): 375-392.
[15]
Verani JR, McGee L, Schrag SJ, et al. Prevention of perinatal group B Streptococcal disease-revised guidelines from CDC, 2010[J]. MMWR Recomm Rep, 2010, 59(RR-10): 1-36.
[16]
Edwards MS, Fuselier PA, Rench MA, et al. Class specificity of natural1y acquired and vaccine-induced antibody to type Ⅲ group B Streptococcal capsular polysaccharide: determination with a radioimmunoprecipitin assay[J]. Infect Immun, 1984, 44(2): 257-261.
[17]
Hunter SK, Andracki ME, Krieg AM. Biodegradable microspheres containing group B Streptococcal vaccine: immune response in mice[J]. Am J Obstet Gynecol, 2001, 185(5): 1174-1179.
[18]
Baker CJ, Rench MA, McInnes P. Immunization of pregnant women with group B Streptococcal type Ⅲ capsular polysaccharide-tetanus toxoid conjugate vaccine[J]. Vaccine, 2003, 21(24): 3468-3472.
[19]
Madhi SA, Cutland CL, Jose L, et al. Maternal group B Streptococcus vaccination results in placental antibody transfer without interfering with response to routine infant vaccination[J]. Vaccine, 2014, 31(16): 256-261.
[20]
Madhi SA, Dangor Z, Heath PT, et al. Considerations for a phase-Ⅲ trial to evaluate a group B Streptococcus polysaccharide-protein conjugate vaccine in pregnant women for the prevention of earlyand late-onset invasive disease in young-infants[J]. Vaccine, 2013, 31(Suppl 4): D52-D57.
[21]
Mahdi SA, Cutland CL, Jose L,et al. Safety and immunogenicity of an investigational maternal trivalent group B Streptococcus vaccine in healthy women and their infants: a randomised phase 1b/2 trial[J]. Lancet Infect Dis,2016, 16(8): 923-934.
[22]
Gray BM, Pritchard DG, Dillon HC. Seroepidemiological studies of group B Streptococcus type Ⅱ[J]. J Infect Dis, 1985, 151(6): 1073-1080.
[23]
Gray BM, Egan ML, Pritchard DG. The group B streptococci: from natural history to the specificity of antibodies[J]. Semin Perinatol, 1990, 14(Suppl 1): 10-21.
[24]
Lin FY, Philips JB, Azimi PH, et al. Level of maternal antibody required to protect neonates against early-onset disease caused by group B Streptococcus type Ⅰa:a multicenter seroepidemiology study[J]. J Infect Dis, 2001, 184(8): 1022-1028.
[25]
Lin FY, Weisman LE, Azimi PH, et al. Level of maternal IgG anti-group B Streptococcus type Ⅲ antibody correlated with protection of neonates against early-onset disease caused by this pathogen[J]. J Infect Dis, 2004, 190(5): 928-934.
[26]
Baker CJ, Carey VJ, Rench MA, et al. Maternal antibody at delivery protects neonates from early-onset group B Streptococcal disease[J]. J Infect Dis, 2014, 209(5): 781-788.
[27]
Gravekamp C, Kasper DL, Paoletti LC, et al. Alpha C protein as a carrier for type Ⅲ capsular polysaccharide and as a protective protein in group B Streptococcal vaccines[J]. Infect Immun, 1999, 67(5): 2491-2496.
[28]
Bohnsack JF, Widjaja K, Ghazizadeh S, et al. A role for C5 and C5a-ase in the acute neutrophil response to group B Streptococcal infections[J]. J Infect Dis, 1997, 175(8): 847-855.
[29]
Cheng Q, Carlson B, Pillai S, et al. Antibody against surface-bound C5a peptidase is opsonic and initiates macrophage killing of group B Streptococci[J]. Infect Immun, 2001, 69(4): 2302-2308.
[30]
Cheng Q, Debol S, Lam H, et al. Immunization with C5a peptidase or peptidase-type Ⅲ polysaccharide conjugate vaccines enhances learance of group B Streptococci from lungs of infected mice[J]. Infect Immun, 2002, 70(11): 6409-6415.
[31]
Larsson C, Stalhammar-Carlemalm M, Lindahl G. Experimental vaccination against group B Streptococcus, and encapsulated bacterium, with highly purified preparations of cell surface proteins Rib and alpha[J]. Infect Immun, 1996, 64(6): 3518-3523.
[32]
Shen X, Lagergård T, Yang Y, et al. Systemic and mucosal immune responses in mice after mucosal immunization with group B Streptococcus type Ⅲ capsular polysaccharide-cholera toxin B subunit conjugate vaccine[J]. Infect Immun, 2000, 68(10): 5749-5755.
[33]
Maione D, Margarit I, Rinaudo CD, et al. Identification of a universal group B Streptococcus vaccine by multiple genome screen[J]. Science, 2005, 309(15): 148-150.
[34]
Romero-Saavedra F, Laverde D, Wobser D, et al. Identification of peptidoglycan-associated proteins as vaccine candidates for enterococcal infections[J]. PLoS One, 2014, 9(11): e111880.
[35]
Fontana MR, Soriani M, Bagnoli F, et al. Protectome analysis: a new selective bioinformatics tool for bacterial vaccine candidate discovery[J]. Mol Cell Proteomics, 2015, 14(2): 418-429.
[1] 农云洁, 黄小桂, 黄裕兰, 农恒荣. 超声在多重肺部感染诊断中的临床应用价值[J/OL]. 中华医学超声杂志(电子版), 2024, 21(09): 872-876.
[2] 姜珊, 李湘燕, 田硕涵, 温冰, 何睿, 齐心. 采用优化抗感染治疗模式改善糖尿病足感染预后的临床观察[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(05): 398-403.
[3] 许月芳, 刘旺, 曾妙甜, 郭宇姝. 多粘菌素B和多粘菌素E治疗外科多重耐药菌感染临床疗效及安全性分析[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 700-703.
[4] 梁孟杰, 朱欢欢, 王行舟, 江航, 艾世超, 孙锋, 宋鹏, 王萌, 刘颂, 夏雪峰, 杜峻峰, 傅双, 陆晓峰, 沈晓菲, 管文贤. 联合免疫治疗的胃癌转化治疗患者预后及术后并发症分析[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 619-623.
[5] 皮尔地瓦斯·麦麦提玉素甫, 李慧灵, 艾克拜尔·艾力, 李赞林, 王志, 克力木·阿不都热依木. 生物补片修补巨大复发性腹壁切口疝临床疗效分析[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(06): 624-628.
[6] 顾熙, 徐子宇, 周澍, 张吴楼, 张业鹏, 林昊, 刘宗航, 嵇振岭, 郑立锋. 腹股沟疝腹膜前间隙无张力修补术后补片感染10 例报道[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(06): 665-669.
[7] 臧宇, 姚胜, 朱新勇, 戎世捧, 田智超. 低温等离子射频消融治疗腹壁疝术后补片感染的临床效果[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(06): 687-692.
[8] 杨闯, 马雪. 腹壁疝术后感染的危险因素分析[J/OL]. 中华疝和腹壁外科杂志(电子版), 2024, 18(06): 693-696.
[9] 胡菊英, 李银华, 洪兰, 王宏勇, 丁先军, 李承美, 谭心海. 儿童感染大叶性肺炎与支气管肺炎临床特征分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 813-816.
[10] 中华医学会器官移植学分会. 肝移植术后缺血性胆道病变诊断与治疗中国实践指南[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 739-748.
[11] 帖璇, 苏晓乐, 王利华. 抗中性粒细胞胞质抗体相关性血管炎治疗研究进展[J/OL]. 中华肾病研究电子杂志, 2024, 13(06): 345-351.
[12] 丛黎, 马林, 陈旭, 李文文, 张亮亮, 周华亭. 改良CT严重指数联合炎症指标在重症急性胰腺炎患者胰腺感染预测及预后评估中的研究[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(05): 432-436.
[13] 贾玲玲, 滕飞, 常键, 黄福, 刘剑萍. 心肺康复在各种疾病中应用的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(09): 859-862.
[14] 颜世锐, 熊辉. 感染性心内膜炎合并急性肾损伤患者的危险因素探索及死亡风险预测[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 618-624.
[15] 李兰兰, 龚忆华, 陈泳欣, 郑纯翠, 易石坚. 失效模式和效果分析模式提高医院保洁人员标准预防依从性的效果[J/OL]. 中华卫生应急电子杂志, 2024, 10(05): 277-280.
阅读次数
全文


摘要