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中华妇幼临床医学杂志(电子版) ›› 2016, Vol. 12 ›› Issue (04) : 458 -462. doi: 10.3877/cma.j.issn.1673-5250.2016.04.016

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综述

呼吸道炎症无创检测技术在儿童支气管哮喘应用的研究进展
夏万敏1   
  1. 1. 610041 成都,四川大学华西第二医院
  • 收稿日期:2015-10-30 修回日期:2016-01-03 出版日期:2016-08-01

Research progress in clinical application of noninvasive detection technology to respiratory inflammatory of bronchial asthma in children

Wanmin Xia1   

  1. 1. Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2015-10-30 Revised:2016-01-03 Published:2016-08-01
  • About author:
    Corresponding author: Liu Hanmin, Email:
引用本文:

夏万敏. 呼吸道炎症无创检测技术在儿童支气管哮喘应用的研究进展[J]. 中华妇幼临床医学杂志(电子版), 2016, 12(04): 458-462.

Wanmin Xia. Research progress in clinical application of noninvasive detection technology to respiratory inflammatory of bronchial asthma in children[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2016, 12(04): 458-462.

儿童呼吸道炎症评估和监测,对于支气管哮喘的病情评价,治疗反应效果、预测急性发作和预后检测均具有重要意义。目前,对于呼吸道炎症检测相关技术,包括无创和有创二类。其中,呼吸道炎症无创检测技术,已成为哮喘管理的重要手段之一,主要包括呼吸道反应性测定、呼出气一氧化氮(FeNO)水平检测、诱导痰技术、血液与尿液白三烯(LT)水平检测,以及呼出气冷凝物(EBC)成分试验等。对呼吸道炎症无创检测技术和判定指标的标准化,是目前影响这些技术在儿童支气管哮喘临床应用的主要问题。

It is essential to assess and monitor respiratory tract inflammation in asthmatic children patients for evaluating severity of bronchial asthma, treatment response and predicting acute exacerbation and outcome. Invasive and noninvasive techniques could be used in monitoring respiratory tract inflammation in asthmatic children patients. Noninvasive techniques have become one of the most important means for the management of asthma, including airway responsiveness detection, level of fractional concentration of exhaled nitric oxide (FeNO) detection, induced sputum detection, concentration of leukotrienes (LT) in blood and urine, and experiment for analysis of ingredients for exhaled breath condensate (EBC). The decision criteria standardization of noninvasive detection technology to respiratory inflammatory of bronchial asthma in children will be the first step, and it is also the main problem that affects the clinical application of these techniques in children with asthma.

[1]
苏苗赏,李昌崇.气道高反应性与儿童支气管哮喘[J/CD].中华妇幼临床医学杂志:电子版,2008,4(3):239-242.
[2]
Alvarez-Puebla MJ, Olaguibel JM, Almudevar E, et al. Mannitol versus hypertonic saline: safety and efficacy of mannitol and hypertonic saline in sputum induction and bronchial hyperreactivity assessment[J]. Chron Respir Dis, 2015, 12(3):197-203.
[3]
Perzanowski MS, Yoo Y. Exhaled nitric oxide and airway hyperresponsiveness to adenosine 5′-monophosphate and methacholine in children with asthma[J]. Int Arch Allergy Immunol, 2015, 166(2):107-113.
[4]
Shim E, Lee E, Yang SI, et al. The association of lung function, bronchial hyperresponsiveness, and exhaled nitric oxide differs between atopic and non-atopic asthma in children[J]. Allergy Asthma Immunol Res, 2015, 7(4):339-345.
[5]
Roos AB, Mori M, Gronneberg R, et al. Elevated exhaled nitric oxide in allergen-provoked asthma is associated with airway epithelial iNOS[J]. PLoS One, 2014, 9(2):e90018.
[6]
Yamamoto M, Tochino Y, Chibana K, et al. Nitric oxide and related enzymes in asthma: relation to severity, enzyme function and inflammation[J]. Clin Exp Allergy, 2012, 42(5): 760-768.
[7]
强巴措珍,刘瀚旻.Notch信号通路在哮喘及T淋巴细胞调节中的作用研究进展[J/CD].中华妇幼临床医学杂志:电子版,2014,10(2):249-255.
[8]
Malerba M, Radaeli A, Olivini A, et al. The combined impact of exhaled nitric oxide and sputum eosinophils monitoring in asthma treatment: a prospective cohort study[J]. Curr Pharm Des, 2015, 21(32):4752-4562.
[9]
Alvarez-Puebla MJ, Olaguibel Rivera JM, Almudevar E, et al. Cut off point for exhaled nitric oxide corresponding to 3% sputum eosinophils[J]. J Investig Allergol Clin Immunol, 2015, 25(2):107-111.
[10]
Sivan Y, Gadish T, Fireman E, et al.The use of exhaled nitric oxide in the diagnosis of asthma in school children[J]. J Pediatr, 2009, 155(2):211-216.
[11]
Cordeiro D, Rudolphus A, Snoey E, et al. Utility of nitric oxide for the diagnosis of asthma in an allergy clinic population[J]. Allergy Asthma Proc, 2011, 32(1):119-126.
[12]
Woo SI, Lee JH, Kim H, et al. Utility of fractional exhaled nitric oxide (FeNO) measurements in diagnosing asthma[J]. Respir Med, 2012, 106(8): 1103-1109.
[13]
Yang S, Park J, Lee YK, et al. Association of longitudinal fractional exhaled nitric oxide measurements with asthma control in atopic children[J]. Respir Med, 2015, 109(5): 572-579.
[14]
Gemicioglu B, Musellim B, Dogan I, et al. Fractional exhaled nitric oxide (FeNO) in different asthma phenotypes[J]. Allergy Rhinol, 2014, 5(2): e157-e161.
[15]
Lu M, Wu B, Che D, et al. FeNO and asthma treatment in children: a systematic review and meta-analysis[J]. Medicine, 2015, 94(4):e347-e350.
[16]
Dweik RA, Boggs PB, Erzurum SC, et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FeNO) for clinical applications[J]. Am J Respir Crit Care Med, 2011, 184(5): 602-615.
[17]
Zacharasiewicz A, Wilson N, Lex CH, et al.Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children[J]. Am J Respir Crit care Med, 2005, 171(10): 1077-1082.
[18]
Ullmann N, Bossley CJ, Fleming L, et al. Blood eosinophil counts rarely reflect airway eosinophilia in children with severe asthma[J]. Allergy, 2013, 68(3):402-406.
[19]
Griffin E, Hakansson L, Formgren H, et al.Blood eosinophil number and activity in relation to lung function in patients with asthma and with eosino-phiha[J]. J Allergy Clin Immunol, 1991, 87(2):548-557.
[20]
Sorva R, Metso T, Turpeinen M, et al. Eosinophil cationic protein in induced sputum as a marker of inflammation in asthmatic children[J]. Pediatr Allergy Immanol, 1997, 8(1):45-50.
[21]
Naseem A, Liaqat J, Zaidi SB, et al.Sputum neutrophilia in severe persistent asthmatics[J]. J Coll Physicians Surg Pak, 2014, 24(6):420-423.
[22]
Moore WC, Hastie AT, Li X, et al. Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis[J]. J Allergy Clin Immunol, 2014, 133(6):1557-1563.
[23]
Rossall M, Cadden P, Kolsum U, et al. A comparison of the clinical and induced sputum characteristics of early- and late-onset asthma[J]. Lung, 2012, 190(4):459-462.
[24]
Okunishi K, Peters-Golden M. Leukotrienes and airway inflammation[J]. Biochim Biophys Acta, 2011, 1810(11):1096-1102.
[25]
Abd El-Motaleb GS, Abou Amer AA, Elawa GM, et al. Study of urinary leukotriene E4 levels in cildren with acute asthma[J]. Int J Gen Med, 2014(7):131-135.
[26]
Chiu CY, Tsai MH, Yao TC, et al.Urinary LTE4 Levels as a diagnostic marker for IgE-mediated asthma in preschool children: a birth cohort study[J]. PLoS One, 2014, 9(12): e115216.
[27]
赵海燕,陈宝元,曹洁, 等. 夜间支气管哮喘患者呼吸功能及尿中白三烯E昼夜节律的研究[J].中华结核和呼吸杂志,2004,27(8):561-562.
[28]
严炜.孟鲁司特钠联合干扰素α1b治疗小儿喘息性支气管炎的临床疗效[J/CD].中华妇幼临床医学杂志:电子版,2015,11(5):605-608.
[29]
Caballero Balanzá S, Aragonés AM, Cerdá Mir JC, et al. Leukotriene B4 and 8-isoprostane in exhaled breath condensate of children with episodic and persistent asthma[J]. J Investig Allergol Clin Immunol, 2010, 20(3): 237-243.
[30]
Wan GH, Yan DC, Tseng HY, et al. Cysteinyl leukotriene levels correlate with 8-isoprostane levels in exhaled breath condensates of atopic and healthy children[J]. Pediatr Res, 2013, 74(5):584-591.
[31]
Tomasiak-Lozowska MM, Zietkowski Z, Przeslaw K, et al. Inflammatory markers and acid-base equilibrium in exhaled breath condensate of stable and unstable asthma patients[J]. Int Arch Allergy Immunol, 2012, 159(5):121-129.
[32]
Loukides S, Kontogianni K, Hillas G, et al. Exhaled breath condensate in asthma: from bench to bedside[J]. Curr Med Chem, 2011, 18(10):1432-1443.
[33]
Bikov A, Galffy G, Tamasi L, et al. Exhaled breath condensate pH is influenced by respiratory droplet dilution[J]. J Breath Res, 2012, 6(4):046002.
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