通过共词分析法建立国内胎儿先天性心脏病(CHD)研究关键词的可视化共现网络，分析我国胎儿CHD研究的发展趋势。

本研究以"胎儿"和"先天性心脏病"为关键词，在中国生物医学文献数据库(CBM)和中国知网(CNKI)数据库检索文献，并限定文献发表时间为1976年1月至2015年12月，共获得符合本研究纳入标准的文献1 458篇为研究对象。将获取的文献分为1976－1995年组、1996－2005年组、2006－2015年组共3个阶段组，采用Endnote X7软件统计各阶段核心关键词及词频，恰当提取合适的核心关键词。利用Excel 2010对核心关键词建立共现矩阵，使用Ucinet 6.0绘制可视化网络。观察3个阶段组核心关键词及其词频的联系与变化。

3个阶段组关于胎儿CHD研究的文献数量分别为94、182、1 182篇，通过共词分析法成功建立我国胎儿CHD的可视化网络。3个阶段组均以"产前检查"及"超声心动图"处于各阶段社会网络核心位置。其中，1976－1995年组纳入文献关于胎儿CHD核心关键词共计20个；1996－2005年组纳入文献关于胎儿CHD核心关键词共计35个，"宫内发育迟缓"逐步趋于中心区域，新增词中，"心外畸形"，"妊娠期疾病"首次出现即位于网络第二层；2006－2015年组纳入文献关于胎儿CHD核心关键词共计55个，核心区域关键词增加包括"心脏缺损"，"静脉导管血流频谱"，"Tei指数"等，大部分新增关键词分布于边缘区域。

我国胎儿CHD研究始于20世纪70年代，近十年来由于胎儿超声心动图的发展，带动了整个胎儿CHD领域的研究，对胎儿CHD疾病的认识、产前诊断及胎儿评估均取得显著进步。目前对于胎儿期CHD的临床干预尚处于摸索期，亟需大量前瞻性临床研究予以完善。

To study the development trend of research on fetal congenital heart disease(CHD) in China through a visualized network based on research key words of fetal CHD with the co-word and social network analysis.

The China Biology Medicine (CBM) and Chinese National Knowledge Infrastructure (CNKI) databases had been searched using the mesh keywords of"fetus"and"congenital heart disease"from January 1976 to December 2015, a total of 1 458 articles in accordance with the accepting criteria of this study were included as the research objects. Enrolled articles were divided into three stage groups as 1976-1995 year group, 1996-2005 year group and 2006-2015 year group.Collected the core key words and their words frequencies, then taken out the proper core key words from above stages with Endnote X7 software. The co-occurrence matrixes were built through Excel 2010, and the visualized networks were drawn using Ucinet 6.0. The connection and changes of domain subject knowledge of all core key words among 3 stage groups and their frequencies were observed and analyzed.

The numbers of enrolled articles on fetal CHD of 3 stage groups above mentioned were 94, 182 and 1 182, respectively. The visualized network of fetal CHD study in China was successfully built.The key words of"prenatal examination"and"echocardiography"were in the central position of the social network in all 3 stage groups.A total of 20 core key words on fetal CHD were in 1976-1995 year group; 35 core key words were in 1996-2005 year group,"intrauterine growth retardation"gradually closed to central position, and the new words of"extracardial anomalies"and"pregnant disease"were first appeared and located in the second gradation; 55 core key words were in 2006-2015 year group, and the number of core key words increased in the central part including"heart defects","blood flow spectrum of ductus venosus"and"Tei index", etc., and new core key words mostly located on the edge area of the network.

The subject knowledge of fetal CHD originated from the middle 1970s in China. Taken the advantage of fetal echocardiography development, fetal CHD studies burst out in recent ten years.The knowledge of fetal CHD, prenatal diagnosis and assessment of fetus achieved remarkable progress.Now the clinic treatment of fetal cardiac intervention is still in the exploration stage and more prospective studies are needed.