探讨剖宫产术后采用低剂量阿司匹林联合空气波压力治疗仪治疗，对术后下肢静脉血栓形成的预防作用。

选择2012年1月至2014年2月于河北医科大学附属深州市医院进行剖宫产分娩的200例产妇为研究对象。将其按照入院顺序号的奇、偶数随机分为研究组(n＝100，采取常规护理＋低剂量阿司匹林联合空气波压力治疗仪治疗)与对照组(n＝100，采取常规护理)。本研究纳入标准：均为剖宫产分娩者，其年龄为18～45岁，同意参与本研究，与家属及受试者本人均签署临床研究知情同意书；排除标准：产前确诊为出、凝血功能障碍者，合并肝、肾、心功能严重不全者，术前曾使用抗凝药物治疗者，以及合并自身免疫性疾病患者。两组受试者年龄、初产妇与经产妇构成比、单胎与多胎妊娠构成比、妊娠合并症种类及其发生率、巨大儿分娩率及分娩孕龄等一般临床资料比较，差异均无统计学意义(P>0.05)，而且两组受试者剖宫产术相关指标(手术时间、术中出血量)等比较，差异亦均无统计学意义(P>0.05)。两组受试者剖宫产术后接受不同干预措施后，统计学分析两组受试者下肢静脉血栓发生率，以及剖宫产术后第3，7及14天时视觉模拟量表(VAS)评分，术后第7天静息心指数(CI)及双下肢肿胀指数。本研究遵循的程序符合深州市医院人体试验委员会所制定的伦理学标准，得到该委员会批准，分组征得受试者本人的知情同意，并与之签署临床研究知情同意书。

研究组剖宫产术后无一例受试者出现下肢静脉血栓，而对照组下肢静脉血栓发生率为10.0%(10/100)，两组比较，差异有统计学意义(χ²＝10.526，P＝0.001)。研究组受试者剖宫产术后第7天时静息CI及双下肢肿胀指数，以及第3，7及14天时VAS评分，均显著低于对照组，且差异均有统计学意义(t＝5.589，8.348，P＝0.000，0.000；t＝2.780，9.446，10.063，P＝0.006，0.000，0.000)。两组受试者剖宫产术后切口愈合时间比较，差异无统计学意义(P>0.05)。

剖宫产术后采取低剂量阿司匹林联合空气波压力治疗仪治疗，对受试者下肢静脉血栓形成具有显著预防效果，可有效降低受试者术后下肢静脉血栓发生率，缓解术后疼痛感，减少对心脏功能损伤，降低双下肢肿胀指数，对改善受试者生存质量，促进术后恢复具有重要意义。

To investigate clinical effect of low-dose aspirin combined with air pressure therapeutic apparatus prevention of vein thrombosis of lower limbs after cesarean section.

From January 2010 to February 2012, a total of 200 cases of pregnant women who delivered with cesarean section in Shenzhou Hospital Affiliated to Hebei Medical University were chosen as study subjects. According to their odd and even number of admission, they were randomly divided into research group (n=100, treated by basic obstetric care and low-dose aspirin combined with air pressure therapeutic apparatus) and control group (n=100, treated by basic obstetric care without using any anticoagulants). Inclusion standards of this study: all subjects delivered by cesarean section, 18-45 years old, performed among whom signed informed consent. Exclusion standards of this study: prenatally diagnosed as coagulation impairments and hemorrhage, had disease of serious heart, hepatic, kidney, especially viscera dysfunction, received anticoagulant therapy before cesarean section, complicated with autoimmune disorders. There were no significant differences between two groups among constituent ratios of age, unipara and multipara, single birth and multifetation, and incidence rates of pregnancy complications, delivery of fetal macrosomia, average gestational age, etc. (P>0.05). There were no significant differences between two groups among correlation index of cesarean section, such as duration of operation, intraoperative blood loss volume, etc. (P>0.05). Incidence of total vein thrombosis of lower limbs after cesarean section taking different clinical intervention between two groups, resting cardiac index (CI) and swelling index of lower limbs at 7-day after cesarean sections, and visual analogue scale (VAS) scores at 3-, 7- and 14-day after cesarean sections between two groups were analyzed by statistical method. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Shenzhou Hospital Affiliated to Hebei Medical University. Informed consent was obtained from all participants.

There was no patient had vein thrombosis of lower limbs after cesarean section in observation group, and in control group, the rate of vein thrombosis of lower limbs was 10.0% (10/100), the difference between two groups was statistical significant (χ²=10.526, P<0.05). Resting CI and swelling index of lower limbs at 7-day after cesarean sections, and VAS scores at 3-, 7- and 14-day after cesarean sections in observation group were much lower than those in control group, and all the differences between two groups were statistically significant (t=5.589, 8.348, P=0.000, 0.000; t=2.780, 9.446, 10.063, P=0.006, 0.000, 0.000). There were no significant differences between two groups in time of wound healing after cesarean section (P>0.05).

Low-dose aspirin combined with air pressure therapeutic apparatus has significant prevention effects in vein thrombosis of lower limbs after the cesarean surgery. This strategy can effectively decrease the incidence of vein thrombosis of lower limbs, relieve postoperative pain, reduce the injury to the heart, decrease swelling index of lower limbs, improve patient life quality and promote postoperative recovery, which should be widely applied in clinic.