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中华妇幼临床医学杂志(电子版) ›› 2015, Vol. 11 ›› Issue (05) : 609 -612. doi: 10.3877/cma.j.issn.1673-5250.2015.05.012

所属专题: 文献

论著

反复性流产夫妇的细胞遗传学因素探讨
欧阳鲁平1, 黄红倩1, 刘天盛1, 费冬梅1, 陈少科1, 郑陈光1,*,*()   
  1. 1. 530003 南宁,广西壮族自治区妇产医院/妇幼保健院遗传代谢中心实验室
  • 收稿日期:2015-06-25 修回日期:2015-09-10 出版日期:2015-10-01
  • 通信作者: 郑陈光

Research of cytogenetics factors on recurrent spontaneous abortion couples

Luping Ouyang1, Hongqian Huang1, Tiansheng Liu1, Dongmei Fei1, Shaoke Chen1, Chenguang Zheng1()   

  1. 1. Guangxi Obstetrics and Gynecology Hospital/Women and Children Care Hospital, Genetic Metabolic Center, Nanning 530003, Guangxi Province, China.
  • Received:2015-06-25 Revised:2015-09-10 Published:2015-10-01
  • Corresponding author: Chenguang Zheng
  • About author:
    Corresponding author: Zheng Chenguang, Email:
引用本文:

欧阳鲁平, 黄红倩, 刘天盛, 费冬梅, 陈少科, 郑陈光. 反复性流产夫妇的细胞遗传学因素探讨[J/OL]. 中华妇幼临床医学杂志(电子版), 2015, 11(05): 609-612.

Luping Ouyang, Hongqian Huang, Tiansheng Liu, Dongmei Fei, Shaoke Chen, Chenguang Zheng. Research of cytogenetics factors on recurrent spontaneous abortion couples[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2015, 11(05): 609-612.

目的

分析反复性流产(RSA)夫妇的染色体检测结果,探讨RSA与染色体异常的关系。

方法

选择2012年1月1日至2014年12月31日于广西壮族自治区妇产医院就诊的1 180对(2 360例)RSA夫妇为研究对象。采用G显带技术对其进行染色体核型分析。本研究遵循的程序符合广西壮族自治区妇产医院人体试验委员会制定的伦理学标准,得到该委员会批准,并征得受试对象及监护人知情同意,与受试对象本人签署临床研究知情同意书。

结果

2 360例检测对象中,检测出染色体异常患者为189例(8.0%),其中,女方染色体异常者为107例,男方染色体异常为82例;RSA=2次患者为135例,RSA=3次为45例,RSA≥4次为9例。189例染色体异常患者中,染色体结构异常为38例(20.1%,包括26例染色体平衡易位、7例罗伯逊易位、4例染色体倒位和1例染色体缺失);染色体多态性为151例[79.9%,包括103例次缢痕增加、21例inv(9)染色体倒位、17例染色体随体柄增长、5例染色体随体增加和5例染色体着丝粒异染色质增加]。

结论

夫妇双方或任意一方染色体异常均是导致RSA的重要细胞遗传学因素。染色体多态性在RSA发病因素中应得到重视。

Objective

To analyze the results of chromosome test in recurrent spontaneous abortion(RSA) couples, and investigate the relationship between RSA and chromosome abnormality.

Methods

From 1st January 2012 to 31st December 2014, a total of 1 180 RSA couples (2 360 cases) were included in the study.Their chromosome karyotype were analyzed by G banding technology. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Guangxi Obstetrics and Gynecology Hospital. Informed consent was obtained from each participates.

Results

189 cases (8.0%) were found abnormal chromosome, there were 107 female cases and 82 male cases among them.In those 189 patients with chromosomal abnormalities, 38 cases (20.1%) were founded abnormal chromosome structurewere, including 26 cases of balanced translocation chromosomes, 7 cases robertsonian translocation, 4 cases chromosome inversion and 1 case chromosome deletion.Meanwhile, 151 cases(79.9%) were founded chromosome polymorphism.It contained 103 cases of secondary constriction increase, 21 cases of inv(9) chromosomal inversion, 17 cases with the body of trabant chromosome increase, 5 cases of trabant chromosome and 5 cases of chromosome centromeric heterochromatin increase.

Conclusions

Chromosome abnormality is one of important genetic factors lead to RSA. Chromosome polymorphism should be more attention in RSA.

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