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中华妇幼临床医学杂志(电子版) ›› 2015, Vol. 11 ›› Issue (4) : 547 -549. doi: 10.3877/cma.j.issn.1673-5250.2015.04.024

所属专题: 文献

综述

基质金属蛋白酶-2,-9对宫内感染新生儿脑损伤的作用
陈丹丹   
  1. 225001 扬州大学临床医学院妇产科
  • 收稿日期:2015-05-10 修回日期:2015-07-02 出版日期:2015-08-01

Effects of matrix metalloproteinase-2, -9 on neonatal brain injury caused by intrauterine infection

Dandan Chen   

  1. Department of Obstetrics and Gynecology, Clinical College, Yangzhou University, Yangzhou 225001, Jiangsu Province, China
  • Received:2015-05-10 Revised:2015-07-02 Published:2015-08-01
引用本文:

陈丹丹. 基质金属蛋白酶-2,-9对宫内感染新生儿脑损伤的作用[J/OL]. 中华妇幼临床医学杂志(电子版), 2015, 11(4): 547-549.

Dandan Chen. Effects of matrix metalloproteinase-2, -9 on neonatal brain injury caused by intrauterine infection[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2015, 11(4): 547-549.

宫内感染与胎膜早破(PROM)互为因果,而这2种因素可极大增高新生儿脑损伤的发生率。目前,宫内感染引起新生儿脑损伤的发生机制尚未明确。基质金属蛋白酶(MMP)-2,-9不仅可参与炎症反应、破坏胎膜组织,还可以破坏血脑屏障(BBB),导致新生儿脑损伤的发生。笔者拟就宫内感染时,MMP-2,-9在母胎血液循环和新生儿脑白质的表达,以及通过监测MMP-2,-9预测新生儿脑损伤发生的意义进行综述。

Intrauterine infection is closely related to premature rupture of membranes(PROM), and these factors can greatly increase the incidence of neonatal brain injury.At present, the mechanism of neonatal brain injury caused by intrauterine infection is not yet clear. Matrix metalloproteinase (MMP)-2, -9 not only participate in inflammation, destruction of membranes, but also take part in the disruption of the blood-brain barrier, then lead to the occurrence of neonatal brain injury. The value of predicting the occurrence of neonatal brain injury through the expression of MMP-2, -9 in mother's and fetal blood circulation and neonatal injury cerebral white matter with intrauterine infection are reviewed in this paper.

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