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中华妇幼临床医学杂志(电子版) ›› 2015, Vol. 11 ›› Issue (03) : 415 -418. doi: 10.3877/cma.j.issn.1673-5250.2015.03.028

所属专题: 文献

综述

原因不明复发性自然流产发病机制的研究进展
刘绪义1, 陈晨2, 李俊强2, 李春梅2,*,*()   
  1. 1. 610041 成都,四川大学华西第二医院妇产科;620000 四川省眉山市妇幼保健院
    2. 610041 成都,四川大学华西第二医院妇产科
  • 收稿日期:2015-04-15 修回日期:2015-05-04 出版日期:2015-06-01
  • 通信作者: 李春梅

Research progress of the pathogenesis of unexplained recurrent spontaneous abortion

Xuyi Liu1, Chen Chen2, Junqiang Li2, Chunmei Li2()   

  1. 1. West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China; Meishan Maternal and Child Health Hospital, Meishan 620000, Sichuan Province, China
    2. West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2015-04-15 Revised:2015-05-04 Published:2015-06-01
  • Corresponding author: Chunmei Li
  • About author:
    Corresponding author: Li Chunmei, Email:
引用本文:

刘绪义, 陈晨, 李俊强, 李春梅. 原因不明复发性自然流产发病机制的研究进展[J/OL]. 中华妇幼临床医学杂志(电子版), 2015, 11(03): 415-418.

Xuyi Liu, Chen Chen, Junqiang Li, Chunmei Li. Research progress of the pathogenesis of unexplained recurrent spontaneous abortion[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2015, 11(03): 415-418.

原因不明复发性自然流产(URSA)病因较为复杂,该病也是造成不孕的主要原因,成为临床诊疗的热点和难点问题。笔者拟就叶酸代谢酶基因突变、人类白细胞抗原(HLA)基因系统表达异常、辅助性T细胞(Th)1/Th2平衡失调、白细胞介素(IL)-18作用和精子因素等5个方面与URSA发病机制的相关研究进展综述如下。

The causes of unexplained recurrent spontaneous abortion(URSA) is extremely complicated, and URSA is the main cause of infertility. This review focuses on research progress of relationship between folate metabolism enzyme gene mutation, human leukocyte antigen(HLA) gene expression abnormalities, disorder of helper T cell (Th)1/Th2 balance, interleukin(IL)-18, sperm factor and the pathogenisis of URSA.

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