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中华妇幼临床医学杂志(电子版) ›› 2015, Vol. 11 ›› Issue (01) : 95 -98. doi: 10.3877/cma.j.issn.1673-5250.2015.01.022

所属专题: 文献

综述

血清微小RNA在恶性肿瘤临床应用中的研究进展
黎玉涵1, 孙小丽1, 罗喜平1,*,*()   
  1. 1. 510010 广州医科大学附属广东省妇幼保健院妇科
  • 收稿日期:2014-09-30 修回日期:2015-01-06 出版日期:2015-02-01
  • 通信作者: 罗喜平

Research progress of the application of serum microRNA in the malignant tumor

Yuhan Li1, Xiaoli Sun1, Xiping Luo1()   

  1. 1. Guangdong Maternal and Child Health Care Hospital, Guangzhou Medical University, Guangzhou 510010, Guangdong Province, China
  • Received:2014-09-30 Revised:2015-01-06 Published:2015-02-01
  • Corresponding author: Xiping Luo
  • About author:
    Corresponding author: Luo Xiping, Email:
引用本文:

黎玉涵, 孙小丽, 罗喜平. 血清微小RNA在恶性肿瘤临床应用中的研究进展[J/OL]. 中华妇幼临床医学杂志(电子版), 2015, 11(01): 95-98.

Yuhan Li, Xiaoli Sun, Xiping Luo. Research progress of the application of serum microRNA in the malignant tumor[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2015, 11(01): 95-98.

微小RNA(miRNA)是一类小分子非编码RNA,能够在转录后水平调控蛋白合成,几乎参与调控细胞活动的各个环节。miRNA不仅在组织中,也在体液(血液、尿液、脑脊液)中稳定存在。血清中的miRNA具有含量丰富、性质稳定、特异性高、易于检测等特点,现已逐渐成为新一代肿瘤标志物,为肿瘤的早期诊断、治疗及预后监测提供有力依据。笔者拟就血清miRNA在恶性肿瘤临床应用中的国内外研究进展进行综述。

MicroRNA (miRNA) are a class of small non-coding RNA, which could regulate protein synthesis on the post-transcriptional level and be involved in the regulation of all aspects of cellular activity. miRNA not only exist stably in the tissues, but also can be found in body fluids, including blood, urine or cerebrospinal fluid. Serum miRNA has many advantages, such as rich content, stable, high specificity, ease of testing, etc.. It is now becoming a new generation of tumor markers for early diagnosis, treatment and prognosis of cancer. This article reviews the literatures on the progress of the application of serum miRNA in the malignant tumor.

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